p53/mdm2 feedback loop sustains miR-221 expression and dictates the response to anticancer treatments in hepatocellular carcinoma

The overexpression of microRNA-221 (miR-221) is reported in several human cancers including hepatocellular carcinoma, and its targeting by tailored treatments has been proposed. The evidence supporting the role of miR-221 in cancer is growing and has been mainly focused on the discovery of miR-221 t...

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Veröffentlicht in:	Molecular cancer research 2014-02, Vol.12 (2), p.203-216
Hauptverfasser:	Fornari, Francesca, Milazzo, Maddalena, Galassi, Marzia, Callegari, Elisa, Veronese, Angelo, Miyaaki, Hisamitsu, Sabbioni, Silvia, Mantovani, Vilma, Marasco, Elena, Chieco, Pasquale, Negrini, Massimo, Bolondi, Luigi, Gramantieri, Laura
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Antineoplastic Agents - pharmacology Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Cell Line, Tumor Doxorubicin - pharmacology Female Gene Expression Regulation, Neoplastic - drug effects Hep G2 Cells Humans Liver Neoplasms - drug therapy Liver Neoplasms - genetics Liver Neoplasms - metabolism Male MicroRNAs - genetics MicroRNAs - metabolism Middle Aged Phosphorylation Proto-Oncogene Proteins c-mdm2 - genetics Proto-Oncogene Proteins c-mdm2 - metabolism Signal Transduction - drug effects Signal Transduction - genetics Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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