Translating genome wide association study results to associations among common diseases: In silico study with an electronic medical record
Highlights • An in silico model on the basis of summary GWAS and SNP LD data was built to represent a disease map. • Clinical data from a large and long running EMR was used to validate this disease map. • SNP-to-disease linkage explains only a small fraction of associations among diseases in an EMR...
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| Veröffentlicht in: | International journal of medical informatics (Shannon, Ireland) Ireland), 2013-09, Vol.82 (9), p.864-874 |
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| container_issue | 9 |
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| container_title | International journal of medical informatics (Shannon, Ireland) |
| container_volume | 82 |
| creator | Anand, Vibha Rosenman, Marc B Downs, Stephen M |
| description | Highlights • An in silico model on the basis of summary GWAS and SNP LD data was built to represent a disease map. • Clinical data from a large and long running EMR was used to validate this disease map. • SNP-to-disease linkage explains only a small fraction of associations among diseases in an EMR. • Thus far clinical data has much greater predictive power for all diseases measured. |
| doi_str_mv | 10.1016/j.ijmedinf.2013.05.003 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1386-5056 |
| ispartof | International journal of medical informatics (Shannon, Ireland), 2013-09, Vol.82 (9), p.864-874 |
| issn | 1386-5056 1872-8243 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1500800239 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Algorithms Bayesian network Bioinformatics Computational Biology Computer Simulation Data mining Databases, Genetic Disease - genetics Electronic Health Records - utilization Electronic medical records (EMRs) Genetic Predisposition to Disease Genome Wide Association Studies (GWAS) Genome, Human Genome-Wide Association Study Humans In silico Integration Internal Medicine Other Polymorphism, Single Nucleotide - genetics Single nucleotide polymorphisms (SNPs) |
| title | Translating genome wide association study results to associations among common diseases: In silico study with an electronic medical record |
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