Alcohol intoxications during adolescence increase motivation for alcohol in adult rats and induce neuroadaptations in the nucleus accumbens

Adolescent alcohol binge drinking constitutes a major vulnerability factor to develop alcoholism. However, mechanisms underlying this susceptibility remain unknown. We evaluated the effect of adolescent binge-like ethanol intoxication on vulnerability to alcohol abuse in Sprague–Dawley rats. To mode...

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Veröffentlicht in:	Neuropharmacology 2013-04, Vol.67, p.521-531
Hauptverfasser:	Alaux-Cantin, Stéphanie, Warnault, Vincent, Legastelois, Rémi, Botia, Béatrice, Pierrefiche, Olivier, Vilpoux, Catherine, Naassila, Mickaël
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological - drug effects Adaptation, Physiological - physiology Adolescence Age Factors Alcohol Alcohol Drinking - metabolism Alcohol Drinking - psychology Alcoholic Intoxication - metabolism Alcoholic Intoxication - psychology Animals Choice Behavior - drug effects Choice Behavior - physiology Conditioning, Operant - drug effects Conditioning, Operant - physiology Ethanol - administration & dosage Gene expression Male Motivation Motivation - physiology Nucleus accumbens Nucleus Accumbens - drug effects Nucleus Accumbens - physiology Rats Rats, Sprague-Dawley Vulnerability
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