Generation and application of dynamic standard reference intervals for analyzing results of comparative genomic hybridization

The present work was aimed at generating the dynamic standard reference intervals (DSRI) and their application for chromosomal-aberration (CA) analysis. The evaluation of the generated DSRI was performed using the DNA samples from four patients with already known CA. High-resolution comparative geno...

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Veröffentlicht in:	Russian journal of genetics 2013-10, Vol.49 (10), p.1072-1077
Hauptverfasser:	Min’zhenkova, M. E., Shilova, N. V., Markova, Zh. G., Antonenko, V. G., Lebedev, I. N., Kozlova, Yu. O., Zemlyakova, V. V., Zolotukhina, T. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Biomedical and Life Sciences Biomedicine Breakpoints Human Genetics Methods Microbial Genetics and Genomics
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	The present work was aimed at generating the dynamic standard reference intervals (DSRI) and their application for chromosomal-aberration (CA) analysis. The evaluation of the generated DSRI was performed using the DNA samples from four patients with already known CA. High-resolution comparative genomic hybridization analysis (HR-CGH) allowed us to not only identify all of the CAs that were not revealed by CGH, but also to detect the breakpoints and to determine the size of chromosomal imbalance.
ISSN:	1022-7954 1608-3369
DOI:	10.1134/S1022795413100062