Antibiotics acting as neuroprotectants via mechanisms independent of their anti-infective activities

This review considers available evidence that some antibiotics have ancillary neuroprotective effects. Notably, β-lactam antibiotics are believed to increase the expression of glutamate transporter GLT1, potentially relieving the neurological excitotoxicity that characterizes disorders like amyotrop...

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Veröffentlicht in:	Neuropharmacology 2013-10, Vol.73, p.174-182
Hauptverfasser:	Stock, Matthew L., Fiedler, Kara J., Acharya, Sreemoyee, Lange, Jennifer K., Mlynarczyk, Gregory S.A., Anderson, Stephen J., McCormack, Garrett R., Kanuri, Sri Harsha, Kondru, Naveen C., Brewer, Matthew T., Carlson, Steve A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic lateral sclerosis Animals Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antibacterial Antifungal beta-Lactams - pharmacology beta-Lactams - therapeutic use Humans Minocycline - pharmacology Minocycline - therapeutic use Nervous System Diseases - drug therapy Neuroprotection Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Sirolimus - pharmacology Sirolimus - therapeutic use
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