Neuroprotective and procognitive effects of sertraline: In vitro and in vivo studies

•Sertraline induced the strongest neurotrophic activity in vivo in SHSY5Y cells.•Sertraline has pro-cognitive effect on young and aged mice.•Sertraline showed up regulation of brain BDNF, phospho-ERK and Bcl-2 in mice.•Sertraline may be the preferred drug in treatment of depressed elderly patients....

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Veröffentlicht in:	Neuroscience letters 2013-08, Vol.550, p.93-97
Hauptverfasser:	Taler, Michal, Miron, Oded, Gil-Ad, Irit, Weizman, Abraham
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BDNF Brain-Derived Neurotrophic Factor - metabolism Cell Line, Tumor Cognition Hippocampus - drug effects Hippocampus - metabolism Humans Maze Learning - drug effects Mice Neurons - drug effects Neurons - metabolism Neuroprotection Neuroprotective Agents - pharmacology Nootropic Agents - pharmacology Selective serotonin reuptake inhibitors Serotonin Uptake Inhibitors - pharmacology Sertraline Sertraline - pharmacology Up-Regulation - drug effects
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