The new mutation L321F in Candida albicans ERG11 gene may be associated with fluconazole resistance

Abstract Background For many years fluconazole has been commonly used to treat Candida infections. However, the indiscriminate use of this antimycotic therapy has favored the emergence of resistant isolates. Mutations in the ERG11 gene have been described as one of the primary mechanisms of resistan...

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Veröffentlicht in:	Revista iberoamericana de micologia 2013-07, Vol.30 (3), p.209-212
Hauptverfasser:	Oliveira Carvalho, Vagner, Okay, Thelma S, Melhem, Márcia S.C, Walderez Szeszs, Maria, del Negro, Gilda M.B
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Candida Candida albicans Candida albicans - drug effects Candida albicans - genetics Candida glabrata - genetics Candida tropicalis - genetics Candidemia - microbiology Candidiasis, Oral - microbiology DNA Mutational Analysis DNA, Fungal - genetics Drug resistance Drug Resistance, Fungal - genetics ERG11 gene Fluconazol Fluconazole Fluconazole - pharmacology Fungal Proteins - chemistry Fungal Proteins - genetics Fungal Proteins - physiology Gen ERG11 Genes, Fungal Humans Infectious Disease Models, Molecular Mutación Mutation Mutation, Missense Point Mutation Protein Conformation Resistencia farmacológica Sterol 14-Demethylase - chemistry Sterol 14-Demethylase - genetics Sterol 14-Demethylase - physiology
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