Trimeric purine nucleoside phosphorylase: Exploring postulated one-third-of-the-sites binding in the transition state

Transition-state analogue inhibitors, immucillins, were reported to bind to trimeric purine nucleoside phosphorylase (PNP) with the stoichiometry of one molecule per enzyme trimer [Miles, R. W.; Tyler, P. C.; Furneaux, R. H.; Bagdassarian, C. K.; Schramm, V. L. Biochem. 1998, 37, 8615]. In attempts...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2012-11, Vol.20 (22), p.6758-6769
Hauptverfasser:	Wielgus-Kutrowska, Beata, Breer, Katarzyna, Hashimoto, Mariko, Hikishima, Sadao, Yokomatsu, Tsutomu, Narczyk, Marta, Dyzma, Alicja, Girstun, Agnieszka, Staroń, Krzysztof, Bzowska, Agnieszka
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Biological and medical sciences Calorimetry calves Catalytic Domain Cattle Cooperativity Enzyme catalysis Enzyme inhibitors Escherichia coli Fluorometry Homooligomeric proteins hypoxanthine Hypoxanthine - chemistry Hypoxanthine - metabolism ITC Ligands Medical sciences Negative cooperativity nucleosides One-third-of-the-sites Pharmacology. Drug treatments phosphorylase protein subunits Purine Nucleosides - chemistry Purine Nucleosides - metabolism Purine-Nucleoside Phosphorylase - chemistry Purine-Nucleoside Phosphorylase - genetics Purine-Nucleoside Phosphorylase - metabolism Pyrimidinones - chemistry Pyrimidinones - metabolism Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Spectroscopic methods stoichiometry Thermodynamics Transition state
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