Analysis of evolution of carbonic anhydrases IV and XV reveals a rich history of gene duplications and a new group of isozymes

Carbonic anhydrase (CA) isozymes CA IV and CA XV are anchored on the extracellular cell surface via glycosylphosphatidylinositol (GPI) linkage. Analysis of evolution of these isozymes in vertebrates reveals an additional group of GPI-linked CAs, CA XVII, which has been lost in mammals. Our work reso...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2013-03, Vol.21 (6), p.1503-1510
Hauptverfasser:	Tolvanen, Martti E.E., Ortutay, Csaba, Barker, Harlan R., Aspatwar, Ashok, Patrikainen, Maarit, Parkkila, Seppo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bioinformatics Biological Evolution carbonate dehydratase Carbonic anhydrase 17 Carbonic Anhydrase IV - classification Carbonic Anhydrase IV - genetics Carbonic Anhydrase IV - metabolism Carbonic Anhydrases - classification Carbonic Anhydrases - genetics Carbonic Anhydrases - metabolism evolution fish Gene Duplication Gene Expression Glycosylation Glycosylphosphatidylinositols - chemistry GPI anchor Humans Isoenzymes - classification Isoenzymes - genetics Isoenzymes - metabolism isozymes N-glycosylation Phylogenetics Phylogeny
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