Synthesis, cyclooxygenase inhibitory effects, and molecular modeling study of 4-aryl-5-(4-(methylsulfonyl)phenyl)-2-alkylthio and -2-alkylsulfonyl-1H-imidazole derivatives

A series of 4-aryl-5-(4-(methylsulfonyl)phenyl)-2-alkylthio and 2-alkylsulfonyl-1H-imidazole derivatives were synthesized. All compounds were tested in human blood assay to determine COX-1 and COX-2 inhibitory potency and selectivity. Among the synthesized compounds, 2-alkylthio series were more pot...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2013-04, Vol.21 (8), p.2355-2362
Hauptverfasser:	Assadieskandar, Amir, Amirhamzeh, Amirali, Salehi, Marjan, Ozadali, Keriman, Ostad, Seyed Nasser, Shafiee, Abbas, Amini, Mohsen
Format:	Artikel
Sprache:	eng
Schlagworte:	active sites Blood Cyclooxygenase 1 - blood Cyclooxygenase 2 - blood Cyclooxygenase Inhibitors - chemical synthesis Cyclooxygenase Inhibitors - chemistry Cyclooxygenase Inhibitors - pharmacology Humans hydrogen bonding Imidazoles - chemical synthesis Imidazoles - chemistry Imidazoles - pharmacology Models, Molecular prostaglandin synthase Structure-Activity Relationship
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