Synthesis and evaluation as potential anticancer agents of novel tetracyclic indenoquinoline derivatives

We report the synthesis and evaluation as potential anticancer agents of a series of tetracyclic indenoquinolines. The compounds, which are obtained through the photoisomerization of Diels–Alder adducts formed between purpurogallin derivatives and nitrosobenzene, have in vitro antiproliferative acti...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2013-03, Vol.21 (5), p.1143-1149
Hauptverfasser:	Chakrabarty, Shubhashis, Croft, Michael S., Marko, Melissa G., Moyna, Guillermo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adducts Adenocarcinoma Anticancer activity antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - toxicity Antitumor agents Benzocycloheptenes - chemical synthesis Benzocycloheptenes - chemistry Benzocycloheptenes - toxicity Camptothecin Camptothecin - chemistry Camptothecin - toxicity Cell Line, Tumor Cell Survival - drug effects Cycloaddition Reaction Cytotoxicity Drug Screening Assays, Antitumor HeLa Cells Humans Indenoquinolines Lung MCF-7 Cells mechanism of action Nitroso Compounds - chemistry Photoisomerization Quinolines - chemical synthesis Quinolines - chemistry Quinolines - toxicity Topoisomerase
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