1-substituted apomorphines as potent dopamine agonists

A novel set of 1-substituted apomorphines as dopaminergic agonists were synthesized according to our new strategy employing the acid-catalyzed rearrangement of diversely functionalized 5β-substituted-6-demethoxythebaines. The activities of new compounds for dopamine receptors subtypes were evaluated...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry 2013-07, Vol.21 (14), p.4143-4150
Hauptverfasser:	Reinart-Okugbeni, Reet, Vonk, Argo, Uustare, Ain, Gyulai, Zsuzsanna, Sipos, Attila, Rinken, Ago
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid-catalyzed rearrangement agonists Apomorphine Apomorphine - chemical synthesis Apomorphine - chemistry Apomorphine - pharmacology Binding Sites dopamine Dopamine agonist Dopamine Agonists - chemical synthesis Dopamine Agonists - chemistry Dopamine Agonists - pharmacology Dopamine D1 and D2 receptors dopamine receptors Drug Design HEK293 Cells Humans hydrophilicity Molecular Structure Morphinandiene Protein Binding - drug effects Receptors, Dopamine - metabolism Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!