The anticonvulsant and sedative effects of Gladiolus dalenii extracts in mice
Abstract Gladiolus dalenii Van Geel is a medicinal plant commonly used in traditional medicine in Africa to treat epilepsy and many other diseases. Two in vivo mouse models (maximal electroshock and pentylenetetrazol-induced convulsions) were used to evaluate the anticonvulsant activities of the pla...
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| Veröffentlicht in: | Epilepsy & behavior 2013-09, Vol.28 (3), p.450-456 |
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| creator | Ngoupaye, G.T Ngo Bum, E Ngah, E Talla, E Moto, F.C.O Taiwe, G.S Rakotonirina, A Rakotonirina, S.V |
| description | Abstract Gladiolus dalenii Van Geel is a medicinal plant commonly used in traditional medicine in Africa to treat epilepsy and many other diseases. Two in vivo mouse models (maximal electroshock and pentylenetetrazol-induced convulsions) were used to evaluate the anticonvulsant activities of the plant extracts. Diazepam-induced sleep was used for the evaluation of the sedative properties. The macerated extract of G. dalenii protected 100 and 83.3% of mice against PTZ- and MES-induced seizures, respectively. The aqueous extract of G. dalenii protected 100 and 83.3% of mice against PTZ- and MES-induced seizures, respectively. The lyophilized extract of G. dalenii also protected 100 and 83.3% of mice against PTZ- and MES-induced seizures, respectively. The coadministration of G. dalenii with diazepam resulted in an additive effect, while the coadministration of G. dalenii with flumazenil or FG7142 resulted in antagonistic effects. The macerate of G. dalenii also exerted sedative activity by reducing the latency time to sleep and increasing the total duration of sleep induced by diazepam. The sleeping time increased from 16 ± 3 min in the control group to 118 ± 11 min at a dose of 150 mg/kg of G. dalenii . The effects of G. dalenii suggested the presence of anticonvulsant and sedative activities that might show efficacy against secondarily generalized tonic–clonic seizures and primary generalized seizures and insomnia in humans. |
| doi_str_mv | 10.1016/j.yebeh.2013.06.014 |
| format | Article |
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Two in vivo mouse models (maximal electroshock and pentylenetetrazol-induced convulsions) were used to evaluate the anticonvulsant activities of the plant extracts. Diazepam-induced sleep was used for the evaluation of the sedative properties. The macerated extract of G. dalenii protected 100 and 83.3% of mice against PTZ- and MES-induced seizures, respectively. The aqueous extract of G. dalenii protected 100 and 83.3% of mice against PTZ- and MES-induced seizures, respectively. The lyophilized extract of G. dalenii also protected 100 and 83.3% of mice against PTZ- and MES-induced seizures, respectively. The coadministration of G. dalenii with diazepam resulted in an additive effect, while the coadministration of G. dalenii with flumazenil or FG7142 resulted in antagonistic effects. The macerate of G. dalenii also exerted sedative activity by reducing the latency time to sleep and increasing the total duration of sleep induced by diazepam. The sleeping time increased from 16 ± 3 min in the control group to 118 ± 11 min at a dose of 150 mg/kg of G. dalenii . The effects of G. dalenii suggested the presence of anticonvulsant and sedative activities that might show efficacy against secondarily generalized tonic–clonic seizures and primary generalized seizures and insomnia in humans.</description><identifier>ISSN: 1525-5050</identifier><identifier>EISSN: 1525-5069</identifier><identifier>DOI: 10.1016/j.yebeh.2013.06.014</identifier><identifier>PMID: 23891766</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Analysis of Variance ; Animal models ; Animals ; Anticonvulsants - therapeutic use ; Botanical medicine ; Brain - drug effects ; Brain - metabolism ; Brain - pathology ; Diazepam - therapeutic use ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drug Therapy, Combination ; Epilepsy ; gamma-Aminobutyric Acid - metabolism ; Gladiolus ; Gladiolus dalenii ; Herbal medicine ; Heterocyclic Compounds, 3-Ring ; Hypnotics and Sedatives ; Insomnia ; Male ; Mice ; Neurology ; Pentylenetetrazole - toxicity ; Phytotherapy - methods ; Plant Extracts - pharmacology ; Psychomotor Performance - drug effects ; Seizures - drug therapy ; Seizures - etiology ; Seizures - pathology ; Sleep - drug effects ; Traditional medicine</subject><ispartof>Epilepsy & behavior, 2013-09, Vol.28 (3), p.450-456</ispartof><rights>Elsevier Inc.</rights><rights>2013 Elsevier Inc.</rights><rights>2013.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c513t-53c4c34085113b1f29676ef9908bd1a7d7497516ea79b0bb7fd5edb7abcc8ef93</citedby><cites>FETCH-LOGICAL-c513t-53c4c34085113b1f29676ef9908bd1a7d7497516ea79b0bb7fd5edb7abcc8ef93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.yebeh.2013.06.014$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23891766$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ngoupaye, G.T</creatorcontrib><creatorcontrib>Ngo Bum, E</creatorcontrib><creatorcontrib>Ngah, E</creatorcontrib><creatorcontrib>Talla, E</creatorcontrib><creatorcontrib>Moto, F.C.O</creatorcontrib><creatorcontrib>Taiwe, G.S</creatorcontrib><creatorcontrib>Rakotonirina, A</creatorcontrib><creatorcontrib>Rakotonirina, S.V</creatorcontrib><title>The anticonvulsant and sedative effects of Gladiolus dalenii extracts in mice</title><title>Epilepsy & behavior</title><addtitle>Epilepsy Behav</addtitle><description>Abstract Gladiolus dalenii Van Geel is a medicinal plant commonly used in traditional medicine in Africa to treat epilepsy and many other diseases. Two in vivo mouse models (maximal electroshock and pentylenetetrazol-induced convulsions) were used to evaluate the anticonvulsant activities of the plant extracts. Diazepam-induced sleep was used for the evaluation of the sedative properties. The macerated extract of G. dalenii protected 100 and 83.3% of mice against PTZ- and MES-induced seizures, respectively. The aqueous extract of G. dalenii protected 100 and 83.3% of mice against PTZ- and MES-induced seizures, respectively. The lyophilized extract of G. dalenii also protected 100 and 83.3% of mice against PTZ- and MES-induced seizures, respectively. The coadministration of G. dalenii with diazepam resulted in an additive effect, while the coadministration of G. dalenii with flumazenil or FG7142 resulted in antagonistic effects. The macerate of G. dalenii also exerted sedative activity by reducing the latency time to sleep and increasing the total duration of sleep induced by diazepam. The sleeping time increased from 16 ± 3 min in the control group to 118 ± 11 min at a dose of 150 mg/kg of G. dalenii . The effects of G. dalenii suggested the presence of anticonvulsant and sedative activities that might show efficacy against secondarily generalized tonic–clonic seizures and primary generalized seizures and insomnia in humans.</description><subject>Analysis of Variance</subject><subject>Animal models</subject><subject>Animals</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Botanical medicine</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Diazepam - therapeutic use</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Therapy, Combination</subject><subject>Epilepsy</subject><subject>gamma-Aminobutyric Acid - metabolism</subject><subject>Gladiolus</subject><subject>Gladiolus dalenii</subject><subject>Herbal medicine</subject><subject>Heterocyclic Compounds, 3-Ring</subject><subject>Hypnotics and Sedatives</subject><subject>Insomnia</subject><subject>Male</subject><subject>Mice</subject><subject>Neurology</subject><subject>Pentylenetetrazole - toxicity</subject><subject>Phytotherapy - methods</subject><subject>Plant Extracts - pharmacology</subject><subject>Psychomotor Performance - drug effects</subject><subject>Seizures - drug therapy</subject><subject>Seizures - etiology</subject><subject>Seizures - pathology</subject><subject>Sleep - drug effects</subject><subject>Traditional medicine</subject><issn>1525-5050</issn><issn>1525-5069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EoqXwC5BQjlw2zMSxnRxAQhW0lYo4UM6WPyaqF29S7GTV_fc4bOmBS08ea553RnqGsbcINQLKD9v6QJZu6waQ1yBrwPYZO0XRiI0A2T9_rAWcsFc5bwEQBceX7KThXY9KylP27eaWKjPOwU3jfom5lOXrq0zezGFPFQ0DuTlX01BdROPDFJdceRNpDKGi-zmZtRvGahccvWYvBhMzvXl4z9jPr19uzi83198vrs4_X2-cQD5vBHet4y10ApFbHJpeKklD30NnPRrlVdsrgZKM6i1YqwYvyFtlrHNd4fgZe3-ce5em3wvlWe9CdhSjGWlaskYBoHrkonsabYs_oTpoCsqPqEtTzokGfZfCzqSDRtCrcr3Vf5XrVbkGqYvyknr3sGCxO_KPmX-OC_DxCFAxsg-UdHaBRkc-pKJW-yk8seDTf3kXwxicib_oQHk7LWkssjXq3GjQP9arr0dHDtD0Tcf_AKAlp40</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Ngoupaye, G.T</creator><creator>Ngo Bum, E</creator><creator>Ngah, E</creator><creator>Talla, E</creator><creator>Moto, F.C.O</creator><creator>Taiwe, G.S</creator><creator>Rakotonirina, A</creator><creator>Rakotonirina, S.V</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20130901</creationdate><title>The anticonvulsant and sedative effects of Gladiolus dalenii extracts in mice</title><author>Ngoupaye, G.T ; Ngo Bum, E ; Ngah, E ; Talla, E ; Moto, F.C.O ; Taiwe, G.S ; Rakotonirina, A ; Rakotonirina, S.V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c513t-53c4c34085113b1f29676ef9908bd1a7d7497516ea79b0bb7fd5edb7abcc8ef93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Analysis of Variance</topic><topic>Animal models</topic><topic>Animals</topic><topic>Anticonvulsants - therapeutic use</topic><topic>Botanical medicine</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Brain - pathology</topic><topic>Diazepam - therapeutic use</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Therapy, Combination</topic><topic>Epilepsy</topic><topic>gamma-Aminobutyric Acid - metabolism</topic><topic>Gladiolus</topic><topic>Gladiolus dalenii</topic><topic>Herbal medicine</topic><topic>Heterocyclic Compounds, 3-Ring</topic><topic>Hypnotics and Sedatives</topic><topic>Insomnia</topic><topic>Male</topic><topic>Mice</topic><topic>Neurology</topic><topic>Pentylenetetrazole - toxicity</topic><topic>Phytotherapy - methods</topic><topic>Plant Extracts - pharmacology</topic><topic>Psychomotor Performance - drug effects</topic><topic>Seizures - drug therapy</topic><topic>Seizures - etiology</topic><topic>Seizures - pathology</topic><topic>Sleep - drug effects</topic><topic>Traditional medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ngoupaye, G.T</creatorcontrib><creatorcontrib>Ngo Bum, E</creatorcontrib><creatorcontrib>Ngah, E</creatorcontrib><creatorcontrib>Talla, E</creatorcontrib><creatorcontrib>Moto, F.C.O</creatorcontrib><creatorcontrib>Taiwe, G.S</creatorcontrib><creatorcontrib>Rakotonirina, A</creatorcontrib><creatorcontrib>Rakotonirina, S.V</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Epilepsy & behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ngoupaye, G.T</au><au>Ngo Bum, E</au><au>Ngah, E</au><au>Talla, E</au><au>Moto, F.C.O</au><au>Taiwe, G.S</au><au>Rakotonirina, A</au><au>Rakotonirina, S.V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The anticonvulsant and sedative effects of Gladiolus dalenii extracts in mice</atitle><jtitle>Epilepsy & behavior</jtitle><addtitle>Epilepsy Behav</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>28</volume><issue>3</issue><spage>450</spage><epage>456</epage><pages>450-456</pages><issn>1525-5050</issn><eissn>1525-5069</eissn><abstract>Abstract Gladiolus dalenii Van Geel is a medicinal plant commonly used in traditional medicine in Africa to treat epilepsy and many other diseases. Two in vivo mouse models (maximal electroshock and pentylenetetrazol-induced convulsions) were used to evaluate the anticonvulsant activities of the plant extracts. Diazepam-induced sleep was used for the evaluation of the sedative properties. The macerated extract of G. dalenii protected 100 and 83.3% of mice against PTZ- and MES-induced seizures, respectively. The aqueous extract of G. dalenii protected 100 and 83.3% of mice against PTZ- and MES-induced seizures, respectively. The lyophilized extract of G. dalenii also protected 100 and 83.3% of mice against PTZ- and MES-induced seizures, respectively. The coadministration of G. dalenii with diazepam resulted in an additive effect, while the coadministration of G. dalenii with flumazenil or FG7142 resulted in antagonistic effects. The macerate of G. dalenii also exerted sedative activity by reducing the latency time to sleep and increasing the total duration of sleep induced by diazepam. The sleeping time increased from 16 ± 3 min in the control group to 118 ± 11 min at a dose of 150 mg/kg of G. dalenii . The effects of G. dalenii suggested the presence of anticonvulsant and sedative activities that might show efficacy against secondarily generalized tonic–clonic seizures and primary generalized seizures and insomnia in humans.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23891766</pmid><doi>10.1016/j.yebeh.2013.06.014</doi><tpages>7</tpages></addata></record> |
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| subjects | Analysis of Variance Animal models Animals Anticonvulsants - therapeutic use Botanical medicine Brain - drug effects Brain - metabolism Brain - pathology Diazepam - therapeutic use Disease Models, Animal Dose-Response Relationship, Drug Drug Therapy, Combination Epilepsy gamma-Aminobutyric Acid - metabolism Gladiolus Gladiolus dalenii Herbal medicine Heterocyclic Compounds, 3-Ring Hypnotics and Sedatives Insomnia Male Mice Neurology Pentylenetetrazole - toxicity Phytotherapy - methods Plant Extracts - pharmacology Psychomotor Performance - drug effects Seizures - drug therapy Seizures - etiology Seizures - pathology Sleep - drug effects Traditional medicine |
| title | The anticonvulsant and sedative effects of Gladiolus dalenii extracts in mice |
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