Mismatch negativity is a stronger indicator of functional outcomes than neurocognition or theory of mind in patients with schizophrenia
Mismatch negativity (MMN) is known to be associated with neurocognition, social cognition, and functional outcomes. The present study explored the relationships of MMN with neurocognition, theory of mind, and functional outcomes in patients with schizophrenia, first-degree relatives of patients with...
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| Veröffentlicht in: | Progress in neuro-psychopharmacology & biological psychiatry 2014-01, Vol.48, p.213-219 |
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| container_title | Progress in neuro-psychopharmacology & biological psychiatry |
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| creator | Lee, Seung-Hwan Sung, Kyongae Lee, Kyong-Sang Moon, Eunok Kim, Chang-Gyu |
| description | Mismatch negativity (MMN) is known to be associated with neurocognition, social cognition, and functional outcomes. The present study explored the relationships of MMN with neurocognition, theory of mind, and functional outcomes in patients with schizophrenia, first-degree relatives of patients with schizophrenia, and healthy controls.
Twenty-five patients with schizophrenia, 21 first-degree relatives of patients with schizophrenia, and 29 healthy controls were recruited. We examined symptom severity, neurocognition, theory of mind, functional outcomes, and MMN.
MMN amplitudes decreased in order of patients with schizophrenia, then first-degree relatives, then healthy controls. MMN amplitude was significantly correlated with measures of neurocognition, theory of mind, and functional outcome measurements in patients with schizophrenia. However, the most powerful correlations were those between MMN in the frontal region and measures of functional outcomes. The power and frequency of the correlations were weaker in first-degree relatives and healthy controls than in patients with schizophrenia. Hierarchical regression analysis revealed that functional outcomes (relative to measures of neurocognition and theory of mind) constituted the most powerful predictor of MMN.
Our results suggest that MMN reflects functional outcomes more efficiently than do measures of neurocognition and theory of mind in patients with schizophrenia.
•MMN was significantly lower in patients with schizophrenia than in healthy controls.•MMN was correlated with symptom scores, neurocognition, ToM, and functional outcome.•MMN is a stronger indicator of functional outcomes than neurocognition or ToM. |
| doi_str_mv | 10.1016/j.pnpbp.2013.10.010 |
| format | Article |
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Twenty-five patients with schizophrenia, 21 first-degree relatives of patients with schizophrenia, and 29 healthy controls were recruited. We examined symptom severity, neurocognition, theory of mind, functional outcomes, and MMN.
MMN amplitudes decreased in order of patients with schizophrenia, then first-degree relatives, then healthy controls. MMN amplitude was significantly correlated with measures of neurocognition, theory of mind, and functional outcome measurements in patients with schizophrenia. However, the most powerful correlations were those between MMN in the frontal region and measures of functional outcomes. The power and frequency of the correlations were weaker in first-degree relatives and healthy controls than in patients with schizophrenia. Hierarchical regression analysis revealed that functional outcomes (relative to measures of neurocognition and theory of mind) constituted the most powerful predictor of MMN.
Our results suggest that MMN reflects functional outcomes more efficiently than do measures of neurocognition and theory of mind in patients with schizophrenia.
•MMN was significantly lower in patients with schizophrenia than in healthy controls.•MMN was correlated with symptom scores, neurocognition, ToM, and functional outcome.•MMN is a stronger indicator of functional outcomes than neurocognition or ToM.</description><identifier>ISSN: 0278-5846</identifier><identifier>EISSN: 1878-4216</identifier><identifier>DOI: 10.1016/j.pnpbp.2013.10.010</identifier><identifier>PMID: 24161665</identifier><identifier>CODEN: PNPPD7</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adult ; Adult and adolescent clinical studies ; Aged ; Biological and medical sciences ; Brain Mapping ; Cognition ; Cognition Disorders - etiology ; Electroencephalography ; Evoked Potentials, Auditory - physiology ; Female ; Functional outcome ; Humans ; Male ; Medical sciences ; Middle Aged ; Mismatch negativity ; Neurocognition ; Neuropharmacology ; Neuropsychological Tests ; Pharmacology. Drug treatments ; Psychiatric Status Rating Scales ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Regression Analysis ; Schizophrenia ; Schizophrenia - complications ; Schizophrenic Psychology ; Statistics, Nonparametric ; Theory of mind ; Theory of Mind - physiology ; Young Adult</subject><ispartof>Progress in neuro-psychopharmacology & biological psychiatry, 2014-01, Vol.48, p.213-219</ispartof><rights>2013 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>2013.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-b0bf5ffc5c8d40c2e42bbdb9ef646782c62e6d5aec48aff2e93037ee1c3091ca3</citedby><cites>FETCH-LOGICAL-c422t-b0bf5ffc5c8d40c2e42bbdb9ef646782c62e6d5aec48aff2e93037ee1c3091ca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pnpbp.2013.10.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28045464$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24161665$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Seung-Hwan</creatorcontrib><creatorcontrib>Sung, Kyongae</creatorcontrib><creatorcontrib>Lee, Kyong-Sang</creatorcontrib><creatorcontrib>Moon, Eunok</creatorcontrib><creatorcontrib>Kim, Chang-Gyu</creatorcontrib><title>Mismatch negativity is a stronger indicator of functional outcomes than neurocognition or theory of mind in patients with schizophrenia</title><title>Progress in neuro-psychopharmacology & biological psychiatry</title><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><description>Mismatch negativity (MMN) is known to be associated with neurocognition, social cognition, and functional outcomes. The present study explored the relationships of MMN with neurocognition, theory of mind, and functional outcomes in patients with schizophrenia, first-degree relatives of patients with schizophrenia, and healthy controls.
Twenty-five patients with schizophrenia, 21 first-degree relatives of patients with schizophrenia, and 29 healthy controls were recruited. We examined symptom severity, neurocognition, theory of mind, functional outcomes, and MMN.
MMN amplitudes decreased in order of patients with schizophrenia, then first-degree relatives, then healthy controls. MMN amplitude was significantly correlated with measures of neurocognition, theory of mind, and functional outcome measurements in patients with schizophrenia. However, the most powerful correlations were those between MMN in the frontal region and measures of functional outcomes. The power and frequency of the correlations were weaker in first-degree relatives and healthy controls than in patients with schizophrenia. Hierarchical regression analysis revealed that functional outcomes (relative to measures of neurocognition and theory of mind) constituted the most powerful predictor of MMN.
Our results suggest that MMN reflects functional outcomes more efficiently than do measures of neurocognition and theory of mind in patients with schizophrenia.
•MMN was significantly lower in patients with schizophrenia than in healthy controls.•MMN was correlated with symptom scores, neurocognition, ToM, and functional outcome.•MMN is a stronger indicator of functional outcomes than neurocognition or ToM.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Brain Mapping</subject><subject>Cognition</subject><subject>Cognition Disorders - etiology</subject><subject>Electroencephalography</subject><subject>Evoked Potentials, Auditory - physiology</subject><subject>Female</subject><subject>Functional outcome</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mismatch negativity</subject><subject>Neurocognition</subject><subject>Neuropharmacology</subject><subject>Neuropsychological Tests</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Regression Analysis</subject><subject>Schizophrenia</subject><subject>Schizophrenia - complications</subject><subject>Schizophrenic Psychology</subject><subject>Statistics, Nonparametric</subject><subject>Theory of mind</subject><subject>Theory of Mind - physiology</subject><subject>Young Adult</subject><issn>0278-5846</issn><issn>1878-4216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc-u1CAUxonReMerT2Bi2Ji4mREoZdqFC3Pjv-QaN7om9PQwZdJCBXrN-AK-ttQZdacryOH3ne9wPkKecrbjjKuXx93s527eCcarUtkxzu6RDW_2zVYKru6TDRPlXjdSXZFHKR0ZKySrHpIrIbniStUb8uOjS5PJMFCPB5Pdncsn6hI1NOUY_AEjdb53YHKINFhqFw_ZBW9GGpYMYcJE82B8kS8xQDh4tz7TQucBQzytoqm0KG3oXAzQ50S_uTzQBIP7HuYhonfmMXlgzZjwyeW8Jl_evvl88357--ndh5vXt1uQQuRtxzpbWws1NL1kIFCKruu7Fq2Sat8IUAJVXxsE2RhrBbblw3tEDhVrOZjqmrw4951j-LpgynpyCXAcjcewJM1rxvYtF0z9Hy2OTLVtKwpanVGIIaWIVs_RTSaeNGd6DUsf9a-w9BrWWixhFdWzi8HSTdj_0fxOpwDPL4BJYEYbjQeX_nINk7VUsnCvzhyWzd05jDpBWTRg7yJC1n1w_xzkJ7dTt40</recordid><startdate>20140103</startdate><enddate>20140103</enddate><creator>Lee, Seung-Hwan</creator><creator>Sung, Kyongae</creator><creator>Lee, Kyong-Sang</creator><creator>Moon, Eunok</creator><creator>Kim, Chang-Gyu</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20140103</creationdate><title>Mismatch negativity is a stronger indicator of functional outcomes than neurocognition or theory of mind in patients with schizophrenia</title><author>Lee, Seung-Hwan ; Sung, Kyongae ; Lee, Kyong-Sang ; Moon, Eunok ; Kim, Chang-Gyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-b0bf5ffc5c8d40c2e42bbdb9ef646782c62e6d5aec48aff2e93037ee1c3091ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Brain Mapping</topic><topic>Cognition</topic><topic>Cognition Disorders - etiology</topic><topic>Electroencephalography</topic><topic>Evoked Potentials, Auditory - physiology</topic><topic>Female</topic><topic>Functional outcome</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mismatch negativity</topic><topic>Neurocognition</topic><topic>Neuropharmacology</topic><topic>Neuropsychological Tests</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Regression Analysis</topic><topic>Schizophrenia</topic><topic>Schizophrenia - complications</topic><topic>Schizophrenic Psychology</topic><topic>Statistics, Nonparametric</topic><topic>Theory of mind</topic><topic>Theory of Mind - physiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Seung-Hwan</creatorcontrib><creatorcontrib>Sung, Kyongae</creatorcontrib><creatorcontrib>Lee, Kyong-Sang</creatorcontrib><creatorcontrib>Moon, Eunok</creatorcontrib><creatorcontrib>Kim, Chang-Gyu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Seung-Hwan</au><au>Sung, Kyongae</au><au>Lee, Kyong-Sang</au><au>Moon, Eunok</au><au>Kim, Chang-Gyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mismatch negativity is a stronger indicator of functional outcomes than neurocognition or theory of mind in patients with schizophrenia</atitle><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><date>2014-01-03</date><risdate>2014</risdate><volume>48</volume><spage>213</spage><epage>219</epage><pages>213-219</pages><issn>0278-5846</issn><eissn>1878-4216</eissn><coden>PNPPD7</coden><abstract>Mismatch negativity (MMN) is known to be associated with neurocognition, social cognition, and functional outcomes. The present study explored the relationships of MMN with neurocognition, theory of mind, and functional outcomes in patients with schizophrenia, first-degree relatives of patients with schizophrenia, and healthy controls.
Twenty-five patients with schizophrenia, 21 first-degree relatives of patients with schizophrenia, and 29 healthy controls were recruited. We examined symptom severity, neurocognition, theory of mind, functional outcomes, and MMN.
MMN amplitudes decreased in order of patients with schizophrenia, then first-degree relatives, then healthy controls. MMN amplitude was significantly correlated with measures of neurocognition, theory of mind, and functional outcome measurements in patients with schizophrenia. However, the most powerful correlations were those between MMN in the frontal region and measures of functional outcomes. The power and frequency of the correlations were weaker in first-degree relatives and healthy controls than in patients with schizophrenia. Hierarchical regression analysis revealed that functional outcomes (relative to measures of neurocognition and theory of mind) constituted the most powerful predictor of MMN.
Our results suggest that MMN reflects functional outcomes more efficiently than do measures of neurocognition and theory of mind in patients with schizophrenia.
•MMN was significantly lower in patients with schizophrenia than in healthy controls.•MMN was correlated with symptom scores, neurocognition, ToM, and functional outcome.•MMN is a stronger indicator of functional outcomes than neurocognition or ToM.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>24161665</pmid><doi>10.1016/j.pnpbp.2013.10.010</doi><tpages>7</tpages></addata></record> |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Adult Adult and adolescent clinical studies Aged Biological and medical sciences Brain Mapping Cognition Cognition Disorders - etiology Electroencephalography Evoked Potentials, Auditory - physiology Female Functional outcome Humans Male Medical sciences Middle Aged Mismatch negativity Neurocognition Neuropharmacology Neuropsychological Tests Pharmacology. Drug treatments Psychiatric Status Rating Scales Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Regression Analysis Schizophrenia Schizophrenia - complications Schizophrenic Psychology Statistics, Nonparametric Theory of mind Theory of Mind - physiology Young Adult |
| title | Mismatch negativity is a stronger indicator of functional outcomes than neurocognition or theory of mind in patients with schizophrenia |
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