Polysaccharide-based nucleic acid nanoformulations
Therapeutic application of nucleic acids requires their encapsulation in nanosized carriers that enable safe and efficient intracellular delivery. Before the desired site of action is reached, drug-loaded nanoparticles (nanomedicines) encounter numerous extra- and intracellular barriers. Judicious n...
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| Veröffentlicht in: | Advanced drug delivery reviews 2013-08, Vol.65 (9), p.1123-1147 |
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| container_title | Advanced drug delivery reviews |
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| creator | Raemdonck, Koen Martens, Thomas F. Braeckmans, Kevin Demeester, Jo De Smedt, Stefaan C. |
| description | Therapeutic application of nucleic acids requires their encapsulation in nanosized carriers that enable safe and efficient intracellular delivery. Before the desired site of action is reached, drug-loaded nanoparticles (nanomedicines) encounter numerous extra- and intracellular barriers. Judicious nanocarrier design is highly needed to stimulate nucleic acid delivery across these barriers and maximize the therapeutic benefit. Natural polysaccharides are widely used for biomedical and pharmaceutical applications due to their inherent biocompatibility. At present, there is a growing interest in applying these biopolymers for the development of nanomedicines. This review highlights various polysaccharides and their derivatives, currently employed in the design of nucleic acid nanocarriers. In particular, recent progress made in polysaccharide-assisted nucleic acid delivery is summarized and the specific benefits that polysaccharides might offer to improve the delivery process are critically discussed.
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| doi_str_mv | 10.1016/j.addr.2013.05.002 |
| format | Article |
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| ispartof | Advanced drug delivery reviews, 2013-08, Vol.65 (9), p.1123-1147 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Chemistry, Pharmaceutical Chitosan Cyclodextrin Dextran Drug Carriers - chemistry Gene therapy Humans Hyaluronic acid Nanomedicine Nanoparticles - chemistry Nucleic Acids - chemistry Plasmid DNA Polysaccharides - chemistry siRNA |
| title | Polysaccharide-based nucleic acid nanoformulations |
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