Alternative CD44 splicing in intestinal stem cells and tumorigenesis
As an important player in stem cells and cancer, CD44 is expressed in multiple isoforms via alternative mRNA splicing. Whether, and if so, how various isoforms play distinct roles in normal stem cells and tumorigenesis remains unclear. In this issue of Oncogene , Zeilstra et al. report studies showi...
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| Veröffentlicht in: | Oncogene 2014-01, Vol.33 (5), p.537-538 |
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| creator | Guo, W Frenette, P S |
| description | As an important player in stem cells and cancer, CD44 is expressed in multiple isoforms via alternative mRNA splicing. Whether, and if so, how various isoforms play distinct roles in normal stem cells and tumorigenesis remains unclear. In this issue of
Oncogene
, Zeilstra
et al.
report studies showing that intestinal stem cells express a specific CD44 variant that promotes intestinal tumorigenesis induced by the activation of Wnt signaling, whereas the more commonly expressed standard CD44 isoform is not expressed by stem cells and does not promote tumor formation. This finding demonstrates an isoform-specific function of CD44 in intestinal stem cells and tumorigenesis. |
| doi_str_mv | 10.1038/onc.2013.260 |
| format | Article |
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Oncogene
, Zeilstra
et al.
report studies showing that intestinal stem cells express a specific CD44 variant that promotes intestinal tumorigenesis induced by the activation of Wnt signaling, whereas the more commonly expressed standard CD44 isoform is not expressed by stem cells and does not promote tumor formation. This finding demonstrates an isoform-specific function of CD44 in intestinal stem cells and tumorigenesis.</description><identifier>ISSN: 0950-9232</identifier><identifier>EISSN: 1476-5594</identifier><identifier>DOI: 10.1038/onc.2013.260</identifier><identifier>PMID: 23831568</identifier><identifier>CODEN: ONCNES</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/337/1645/1946 ; 631/67/71 ; 692/420/755 ; Adenomatous Polyposis Coli - genetics ; Animals ; Apoptosis ; Cancer ; Carcinogenesis ; Cell Biology ; Cell Transformation, Neoplastic - genetics ; commentary ; Human Genetics ; Hyaluronan Receptors - genetics ; Hyaluronan Receptors - metabolism ; Internal Medicine ; Intestinal Neoplasms - metabolism ; Medicine ; Medicine & Public Health ; Oncology ; Oncology, Experimental ; Pathogenesis ; Stem cells ; Studies ; Tumors</subject><ispartof>Oncogene, 2014-01, Vol.33 (5), p.537-538</ispartof><rights>Macmillan Publishers Limited 2014</rights><rights>COPYRIGHT 2014 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jan 30, 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c523t-3592c82c514c03976af9c9715dec26f0b26398d54681baaaa6c56b4466bf20c83</citedby><cites>FETCH-LOGICAL-c523t-3592c82c514c03976af9c9715dec26f0b26398d54681baaaa6c56b4466bf20c83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23831568$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guo, W</creatorcontrib><creatorcontrib>Frenette, P S</creatorcontrib><title>Alternative CD44 splicing in intestinal stem cells and tumorigenesis</title><title>Oncogene</title><addtitle>Oncogene</addtitle><addtitle>Oncogene</addtitle><description>As an important player in stem cells and cancer, CD44 is expressed in multiple isoforms via alternative mRNA splicing. Whether, and if so, how various isoforms play distinct roles in normal stem cells and tumorigenesis remains unclear. In this issue of
Oncogene
, Zeilstra
et al.
report studies showing that intestinal stem cells express a specific CD44 variant that promotes intestinal tumorigenesis induced by the activation of Wnt signaling, whereas the more commonly expressed standard CD44 isoform is not expressed by stem cells and does not promote tumor formation. 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Whether, and if so, how various isoforms play distinct roles in normal stem cells and tumorigenesis remains unclear. In this issue of
Oncogene
, Zeilstra
et al.
report studies showing that intestinal stem cells express a specific CD44 variant that promotes intestinal tumorigenesis induced by the activation of Wnt signaling, whereas the more commonly expressed standard CD44 isoform is not expressed by stem cells and does not promote tumor formation. This finding demonstrates an isoform-specific function of CD44 in intestinal stem cells and tumorigenesis.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>23831568</pmid><doi>10.1038/onc.2013.260</doi><tpages>2</tpages></addata></record> |
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| subjects | 631/337/1645/1946 631/67/71 692/420/755 Adenomatous Polyposis Coli - genetics Animals Apoptosis Cancer Carcinogenesis Cell Biology Cell Transformation, Neoplastic - genetics commentary Human Genetics Hyaluronan Receptors - genetics Hyaluronan Receptors - metabolism Internal Medicine Intestinal Neoplasms - metabolism Medicine Medicine & Public Health Oncology Oncology, Experimental Pathogenesis Stem cells Studies Tumors |
| title | Alternative CD44 splicing in intestinal stem cells and tumorigenesis |
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