De novo tyrosinase inhibitor: 4-(6,7-Dihydro-5H-indeno[5,6-d]thiazol-2-yl)benzene-1,3-diol (MHY1556)

In this study, we have synthesized and studied de novo tyrosinase inhibitor, MHY1556, which showed significantly better efficacy than other pre-existing tyrosinase inhibitors in vitro experiments. The IC50 value of MHY1556 was 0.50μM which was significantly lower than that of kojic acid (IC50=53.95μ...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2013-07, Vol.23 (14), p.4172-4176
Hauptverfasser:	Park, June Whan, Ha, Young Mi, Moon, Kyung-mi, Kim, So-ra, Jeong, Hyoung Oh, Park, Yun Jung, Lee, Hye Jin, Park, Ji Young, Song, Yu Min, Chun, Pusoon, Byun, Youngjoo, Moon, Hyung Ryong, Chung, Hae Young
Format:	Artikel
Sprache:	eng
Schlagworte:	4-(6,7-Dihydro-5H-indeno[5,6-d]thiazol-2-yl)benzene-1,3-diol Agaricales - enzymology Animals Benzothiazoles - chemical synthesis Benzothiazoles - metabolism Benzothiazoles - toxicity Binding Sites Cell Line, Tumor Cell Survival - drug effects Enzyme Inhibitors - chemistry Enzyme Inhibitors - metabolism Enzyme Inhibitors - toxicity Kojic acid Melanogenesis Mice Molecular Docking Simulation Monophenol Monooxygenase - antagonists & inhibitors Monophenol Monooxygenase - metabolism Protein Binding Protein Structure, Tertiary Pyrones - chemistry Pyrones - metabolism Pyrones - toxicity Resorcinols - chemical synthesis Resorcinols - metabolism Resorcinols - toxicity Skin-whitening product Tyrosinase inhibitor
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