Global gene expression profiling of monocyte-derived macrophages from red deer (Cervus elaphus) genotypically resistant or susceptible to Mycobacterium avium subspecies paratuberculosis infection

► We investigate the response of cervine macrophages to MAP infection. ► Macrophages were obtained from Johne’s disease resistant (R) or susceptible (S) deer. ► Cell transcriptome profiles were examined by RNA-Seq after MAP infection in vitro. ► Among highly upregulated genes were those related to c...

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Veröffentlicht in:	Developmental and comparative immunology 2013-06, Vol.40 (2), p.210-217
Hauptverfasser:	Marfell, Brooke J., O’Brien, Rory, Griffin, J. Frank T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals breeds Cervus elaphus chemokine CCL8 chemokine CXCL10 chemotaxis Deer Deer - genetics Deer - immunology disease resistance Disease Resistance - genetics Female gene expression Gene Expression Profiling gene expression regulation Gene Expression Regulation - immunology genes Genetic Markers Genetic Predisposition to Disease Host-Pathogen Interactions Immunologic Factors - genetics Immunologic Factors - metabolism inflammatory bowel disease interferons Macrophage response macrophages Macrophages - immunology Macrophages - metabolism Macrophages - microbiology Male Mycobacterium avium Mycobacterium avium subsp. paratuberculosis Mycobacterium avium subsp. paratuberculosis - immunology Paratuberculosis Paratuberculosis - genetics Paratuberculosis - immunology Paratuberculosis - metabolism phenotype Resistance Ruminantia ruminants Sequence Analysis, DNA Susceptibility Transcriptome transcriptomics
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