Targeted co-delivery of docetaxel, cisplatin and herceptin by vitamin E TPGS-cisplatin prodrug nanoparticles for multimodality treatment of cancer

We developed a nanocarrier system of herceptin-conjugated nanoparticles of d-alpha-tocopheryl-co-poly(ethylene glycol) 1000 succinate (TPGS)-cisplatin prodrug (HTCP NPs) for targeted co-delivery of cisplatin, docetaxel and herceptin for multimodality treatment of breast cancer of high human epiderma...

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Veröffentlicht in:	Journal of controlled release 2013-08, Vol.169 (3), p.185-192
Hauptverfasser:	Mi, Yu, Zhao, Jing, Feng, Si-Shen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - pharmacology Anticancer drugs Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antitumor agents Biodegradable copolymers Breast - drug effects Breast - pathology breast neoplasms Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cancer nanotechnology Cell Line, Tumor cisplatin Cisplatin - administration & dosage Cisplatin - pharmacology Combination therapy composite polymers Drug Carriers - chemistry epidermal growth factor receptors ethylene glycol Female Humans hydrophilicity hydrophobicity inhibitory concentration 50 lactic acid Mice nanocarriers Nanomedicine nanoparticles Nanoparticles - chemistry NIH 3T3 Cells Polyethylene Glycols - chemistry Prodrugs - administration & dosage Prodrugs - pharmacology succinic acid Taxanes Taxoids - administration & dosage Taxoids - pharmacology Trastuzumab vitamin E Vitamin E - analogs & derivatives Vitamin E - chemistry
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