Comparison of the glycosylation of in vitro generated polyclonal human IgG and therapeutic immunoglobulins

•Culturing of IgG producing B cells with reproducible proliferation rate.•High viability and good maintenance of the cell repertoire.•Glycosylation profiles of in vitro produced IgG and commercial IVIG had similarities.•Levels of bisecting GlcNAc bearing N-glycans were higher in in vitro produced Ig...

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Veröffentlicht in:	Molecular immunology 2014-02, Vol.57 (2), p.255-262
Hauptverfasser:	Ritamo, Ilja, Cloutier, Marc, Valmu, Leena, Néron, Sonia, Räbinä, Jarkko
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibody B-Lymphocytes - immunology B-Lymphocytes - metabolism Cell Culture Techniques Cell Proliferation Cells, Cultured Chromatography, High Pressure Liquid Fc receptor Glycosylation Humans IgG Immunoglobulin G - analysis Immunologic Memory - immunology Mass Spectrometry
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