CXCL12 N-terminal end is sufficient to induce chemotaxis and proliferation of neural stem/progenitor cells

Neural stem/progenitor cells (NSC) respond to injury after brain injuries secreting IL-1, IL-6, TNF-α, IL-4 and IL-10, as well as chemokine members of the CC and CXC ligand families. CXCL12 is one of the chemokines secreted at an injury site and is known to attract NSC-derived neuroblasts, cells tha...

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Veröffentlicht in:	Stem cell research 2013-09, Vol.11 (2), p.913-925
Hauptverfasser:	Filippo, Thais R.M., Galindo, Layla T., Barnabe, Gabriela F., Ariza, Carolina B., Mello, Luiz E., Juliano, Maria A., Juliano, Luiz, Porcionatto, Marimélia A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Cell Growth Processes - physiology Cell Movement - physiology Cerebellum - cytology Chemokine CXCL12 - genetics Chemokine CXCL12 - metabolism Chemotaxis - physiology Chemotaxis, Leukocyte - physiology Humans Mice Mice, Inbred C57BL Neural Stem Cells - cytology Neural Stem Cells - metabolism Signal Transduction
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