The hypoxic environment reprograms the cytokine/chemokine expression profile of human mature dendritic cells

Abstract Myeloid dendritic cells (DCs) are professional antigen-presenting cells critical for the orchestration of immunity and maintenance of self-tolerance. DC development and functions are tightly regulated by a complex network of inhibitory and activating signals present in the tissue microenvir...

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Veröffentlicht in:	Immunobiology (1979) 2013-01, Vol.218 (1), p.76-89
Hauptverfasser:	Blengio, Fabiola, Raggi, Federica, Pierobon, Daniele, Cappello, Paola, Eva, Alessandra, Giovarelli, Mirella, Varesio, Luigi, Bosco, Maria Carla
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Allergy and Immunology Cell Differentiation Cell Hypoxia - immunology Cell Movement Cells, Cultured Cellular Microenvironment - immunology Chemokines - genetics Chemokines - metabolism Chemokines/cytokines Cytokines - genetics Cytokines - metabolism Dendritic cells Dendritic Cells - immunology Gene Expression Regulation - immunology Gene regulation Humans Hypoxia Immunity, Cellular - genetics Inflammation Inflammation Mediators - metabolism Monocytes - immunology Neovascularization, Pathologic - genetics Osteogenesis - genetics Osteopontin - genetics Osteopontin - metabolism Transcriptome Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism
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