Osteogenesis of Heterotopically Transplanted Mesenchymal Stromal Cells in Rat Models of Chronic Kidney Disease

ABSTRACT The current study is based on the hypothesis of mesenchymal stromal cells (MSCs) contributing to soft‐tissue calcification and ectopic osteogenesis in chronic kidney disease (CKD). Rat MSCs were transplanted intraperitoneally in an established three‐dimensional collagen‐based model in healt...

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Veröffentlicht in:	Journal of bone and mineral research 2013-12, Vol.28 (12), p.2523-2534
Hauptverfasser:	Kramann, Rafael, Kunter, Uta, Brandenburg, Vincent M, Leisten, Isabelle, Ehling, Josef, Klinkhammer, Barbara M, Knüchel, Ruth, Floege, Jürgen, Schneider, Rebekka K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Animals Aorta - metabolism Biomarkers - metabolism Bone Morphogenetic Proteins - metabolism Calcification, Physiologic Cell Differentiation Cell Movement CHRONIC KIDNEY DISEASE Collagen - metabolism Core Binding Factor Alpha 1 Subunit - metabolism Disease Models, Animal Extracellular Matrix - metabolism Gels Gene Expression Regulation Genetic Markers Kidney Function Tests Male MATRIX REMODELING Mesenchymal Stem Cell Transplantation MESENCHYMAL STROMAL CELLS Mesenchymal Stromal Cells - cytology Nephrectomy Organic Chemicals - metabolism OSTEOGENESIS Pericytes - metabolism Rats Renal Insufficiency, Chronic - physiopathology Renal Insufficiency, Chronic - therapy Transplantation, Heterotopic Up-Regulation VASCULAR CALCIFICATION
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