Intracerebroventricular administration of ouabain, a Na/K-ATPase inhibitor, activates mTOR signal pathways and protein translation in the rat frontal cortex

Intracerebroventricular (ICV) injection of ouabain, a specific Na/K-ATPase inhibitor, induces behavioral changes in rats in a putative animal model of mania. The binding of ouabain to Na/K-ATPase affects signaling molecules in vitro, including ERK1/2 and Akt, which promote protein translation. We ha...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Progress in neuro-psychopharmacology & biological psychiatry 2013-08, Vol.45, p.73-82
Hauptverfasser:	Kim, Se Hyun, Yu, Hyun-Sook, Park, Hong Geun, Ha, Kyooseob, Kim, Yong Sik, Shin, Soon Young, Ahn, Yong Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies AKT protein Animals Biological and medical sciences Bipolar disorder Bipolar disorders Carrier Proteins - metabolism Enzyme Inhibitors - administration & dosage Enzyme Inhibitors - pharmacology Eukaryotic Initiation Factors - metabolism Frontal Lobe - drug effects Frontal Lobe - metabolism Injections, Intraventricular Male Medical sciences Mood disorders Motor Activity - drug effects Na-pump Ouabain - administration & dosage Ouabain - pharmacology p70S6K Phosphoproteins - metabolism Phosphorylation - drug effects Protein Biosynthesis - drug effects Protein synthesis Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Rats Ribosomal Protein S6 Kinases, 70-kDa - metabolism Ribosome Subunits, Small - metabolism Signal Transduction - drug effects Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors TOR Serine-Threonine Kinases - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!