CCL21 attenuates HSV-induced inflammation through up-regulation of CD8+ memory cells
Abstract CCR7 and its ligand, CCL21, are known to establish microenvironments for the initiation of immune responses in secondary lymphoid tissue. It has also been reported that CCR7 ligand gene-deleted mice have defects in lymphocyte homing. In addition, the injection of the CCR7 ligand was shown t...
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| Veröffentlicht in: | Immunobiology (1979) 2013-04, Vol.218 (4), p.579-590 |
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| creator | Choi, Bunsoon Lim, Hyun Chul Lee, Eun-So Anower, A.K.M. Mostafa Sohn, Seonghyang |
| description | Abstract CCR7 and its ligand, CCL21, are known to establish microenvironments for the initiation of immune responses in secondary lymphoid tissue. It has also been reported that CCR7 ligand gene-deleted mice have defects in lymphocyte homing. In addition, the injection of the CCR7 ligand was shown to induce the expression of memory T cells. In this study, we analyzed the expression of CCR7 and its ligand in HSV-induced Behçet's disease (BD)-like inflammation of mice. Additionally, plasmids containing the CCR7 ligand CCL19 or CCL21, pcDNA3.1-CCL19 or pcDNA3.1-CCL21, respectively, were injected into symptomatic mice, and changes in the population of memory T cells were determined. After administration of pcDNA3.1-CCL21, the frequencies of CD8+CD44+, CD8+CD62L− memory T cells were significantly up-regulated and the symptoms were not deteriorated when compared to the control vector injected group. Specifically, the difference in frequencies of CCR7+ peripheral blood mononuclear cells between active BD patients and inactive BD patients was similar to that of HSV-induced BD-like mice. These results suggest that CCR7, its ligand, and CD8+ memory cells are correlated with the regulation of BD symptoms. |
| doi_str_mv | 10.1016/j.imbio.2012.07.003 |
| format | Article |
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Mostafa ; Sohn, Seonghyang</creator><creatorcontrib>Choi, Bunsoon ; Lim, Hyun Chul ; Lee, Eun-So ; Anower, A.K.M. Mostafa ; Sohn, Seonghyang</creatorcontrib><description>Abstract CCR7 and its ligand, CCL21, are known to establish microenvironments for the initiation of immune responses in secondary lymphoid tissue. It has also been reported that CCR7 ligand gene-deleted mice have defects in lymphocyte homing. In addition, the injection of the CCR7 ligand was shown to induce the expression of memory T cells. In this study, we analyzed the expression of CCR7 and its ligand in HSV-induced Behçet's disease (BD)-like inflammation of mice. Additionally, plasmids containing the CCR7 ligand CCL19 or CCL21, pcDNA3.1-CCL19 or pcDNA3.1-CCL21, respectively, were injected into symptomatic mice, and changes in the population of memory T cells were determined. After administration of pcDNA3.1-CCL21, the frequencies of CD8+CD44+, CD8+CD62L− memory T cells were significantly up-regulated and the symptoms were not deteriorated when compared to the control vector injected group. Specifically, the difference in frequencies of CCR7+ peripheral blood mononuclear cells between active BD patients and inactive BD patients was similar to that of HSV-induced BD-like mice. These results suggest that CCR7, its ligand, and CD8+ memory cells are correlated with the regulation of BD symptoms.</description><identifier>ISSN: 0171-2985</identifier><identifier>EISSN: 1878-3279</identifier><identifier>DOI: 10.1016/j.imbio.2012.07.003</identifier><identifier>PMID: 22884357</identifier><language>eng</language><publisher>Netherlands: Elsevier GmbH</publisher><subject>Adult ; Advanced Basic Science ; Allergy and Immunology ; Animals ; Behcet Syndrome - genetics ; Behcet Syndrome - immunology ; Behcet Syndrome - pathology ; Behcet Syndrome - virology ; Behçet's disease ; CCL21 ; CCR7 ; CD8+ memory T cells ; CD8-Positive T-Lymphocytes - immunology ; CD8-Positive T-Lymphocytes - pathology ; Cercopithecus aethiops ; Chemokine CCL21 - genetics ; Chemokine CCL21 - immunology ; Disease Models, Animal ; Female ; Herpes Simplex - genetics ; Herpes Simplex - immunology ; Herpes Simplex - pathology ; Herpes Simplex - virology ; Herpes simplex virus-induced inflammation ; Herpesvirus 1, Human - immunology ; Humans ; Immunologic Memory ; Inflammation - genetics ; Inflammation - immunology ; Inflammation - pathology ; Inflammation - virology ; Male ; Mice ; Mice, Inbred ICR ; Middle Aged ; Mouse model ; Receptors, CCR7 - genetics ; Receptors, CCR7 - immunology ; Up-Regulation - immunology ; Vero Cells</subject><ispartof>Immunobiology (1979), 2013-04, Vol.218 (4), p.579-590</ispartof><rights>Elsevier GmbH</rights><rights>2012 Elsevier GmbH</rights><rights>Copyright © 2012 Elsevier GmbH. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-8d3f37903c721b6d511c7735ce2e1041ed5f114959a7a6878b7383e7d46afea93</citedby><cites>FETCH-LOGICAL-c525t-8d3f37903c721b6d511c7735ce2e1041ed5f114959a7a6878b7383e7d46afea93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0171298512001672$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22884357$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, Bunsoon</creatorcontrib><creatorcontrib>Lim, Hyun Chul</creatorcontrib><creatorcontrib>Lee, Eun-So</creatorcontrib><creatorcontrib>Anower, A.K.M. Mostafa</creatorcontrib><creatorcontrib>Sohn, Seonghyang</creatorcontrib><title>CCL21 attenuates HSV-induced inflammation through up-regulation of CD8+ memory cells</title><title>Immunobiology (1979)</title><addtitle>Immunobiology</addtitle><description>Abstract CCR7 and its ligand, CCL21, are known to establish microenvironments for the initiation of immune responses in secondary lymphoid tissue. It has also been reported that CCR7 ligand gene-deleted mice have defects in lymphocyte homing. In addition, the injection of the CCR7 ligand was shown to induce the expression of memory T cells. In this study, we analyzed the expression of CCR7 and its ligand in HSV-induced Behçet's disease (BD)-like inflammation of mice. Additionally, plasmids containing the CCR7 ligand CCL19 or CCL21, pcDNA3.1-CCL19 or pcDNA3.1-CCL21, respectively, were injected into symptomatic mice, and changes in the population of memory T cells were determined. After administration of pcDNA3.1-CCL21, the frequencies of CD8+CD44+, CD8+CD62L− memory T cells were significantly up-regulated and the symptoms were not deteriorated when compared to the control vector injected group. Specifically, the difference in frequencies of CCR7+ peripheral blood mononuclear cells between active BD patients and inactive BD patients was similar to that of HSV-induced BD-like mice. These results suggest that CCR7, its ligand, and CD8+ memory cells are correlated with the regulation of BD symptoms.</description><subject>Adult</subject><subject>Advanced Basic Science</subject><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Behcet Syndrome - genetics</subject><subject>Behcet Syndrome - immunology</subject><subject>Behcet Syndrome - pathology</subject><subject>Behcet Syndrome - virology</subject><subject>Behçet's disease</subject><subject>CCL21</subject><subject>CCR7</subject><subject>CD8+ memory T cells</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>CD8-Positive T-Lymphocytes - pathology</subject><subject>Cercopithecus aethiops</subject><subject>Chemokine CCL21 - genetics</subject><subject>Chemokine CCL21 - immunology</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Herpes Simplex - genetics</subject><subject>Herpes Simplex - immunology</subject><subject>Herpes Simplex - pathology</subject><subject>Herpes Simplex - virology</subject><subject>Herpes simplex virus-induced inflammation</subject><subject>Herpesvirus 1, Human - immunology</subject><subject>Humans</subject><subject>Immunologic Memory</subject><subject>Inflammation - genetics</subject><subject>Inflammation - immunology</subject><subject>Inflammation - pathology</subject><subject>Inflammation - virology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Middle Aged</subject><subject>Mouse model</subject><subject>Receptors, CCR7 - genetics</subject><subject>Receptors, CCR7 - immunology</subject><subject>Up-Regulation - immunology</subject><subject>Vero Cells</subject><issn>0171-2985</issn><issn>1878-3279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNksFu1DAQhi0EokvhCZBQjkgowWPHsXMACYVCkVbi0MLV8jqT1ksSL3aMtG9fhy0cuJSTJev7PZ75hpCXQCug0LzdV27aOV8xCqyisqKUPyIbUFKVnMn2MdlQkFCyVokz8izGPaXQMqmekjPGlKq5kBty3XVbBoVZFpyTWTAWl1ffSzf3yWJfuHkYzTSZxfm5WG6DTze3RTqUAW_SeLr1Q9F9VG-KCScfjoXFcYzPyZPBjBFf3J_n5Nuni-vustx-_fyl-7AtrWBiKVXPBy5byq1ksGt6AWCl5MIiQ6A1YC8GgLoVrZGmyX3tJFccZV83ZkDT8nPy-vTuIfifCeOiJxfXH5gZfYoaBKVSqrplD6OccZUnCfV_oNBQIVqpMspPqA0-xoCDPgQ3mXDUQPUqSe_1b0l6laSp1FlSTr26L5B2E_Z_M3-sZODdCcA8vF8Og47W4ZyNuIB20b13DxR4_0_ejm521ow_8Ihx71OYsxcNOuaMvlr3ZF0TYHlFGsn4HXhrtdk</recordid><startdate>20130401</startdate><enddate>20130401</enddate><creator>Choi, Bunsoon</creator><creator>Lim, Hyun Chul</creator><creator>Lee, Eun-So</creator><creator>Anower, A.K.M. Mostafa</creator><creator>Sohn, Seonghyang</creator><general>Elsevier GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20130401</creationdate><title>CCL21 attenuates HSV-induced inflammation through up-regulation of CD8+ memory cells</title><author>Choi, Bunsoon ; Lim, Hyun Chul ; Lee, Eun-So ; Anower, A.K.M. Mostafa ; Sohn, Seonghyang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c525t-8d3f37903c721b6d511c7735ce2e1041ed5f114959a7a6878b7383e7d46afea93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Advanced Basic Science</topic><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Behcet Syndrome - genetics</topic><topic>Behcet Syndrome - immunology</topic><topic>Behcet Syndrome - pathology</topic><topic>Behcet Syndrome - virology</topic><topic>Behçet's disease</topic><topic>CCL21</topic><topic>CCR7</topic><topic>CD8+ memory T cells</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>CD8-Positive T-Lymphocytes - pathology</topic><topic>Cercopithecus aethiops</topic><topic>Chemokine CCL21 - genetics</topic><topic>Chemokine CCL21 - immunology</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Herpes Simplex - genetics</topic><topic>Herpes Simplex - immunology</topic><topic>Herpes Simplex - pathology</topic><topic>Herpes Simplex - virology</topic><topic>Herpes simplex virus-induced inflammation</topic><topic>Herpesvirus 1, Human - immunology</topic><topic>Humans</topic><topic>Immunologic Memory</topic><topic>Inflammation - genetics</topic><topic>Inflammation - immunology</topic><topic>Inflammation - pathology</topic><topic>Inflammation - virology</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Middle Aged</topic><topic>Mouse model</topic><topic>Receptors, CCR7 - genetics</topic><topic>Receptors, CCR7 - immunology</topic><topic>Up-Regulation - immunology</topic><topic>Vero Cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, Bunsoon</creatorcontrib><creatorcontrib>Lim, Hyun Chul</creatorcontrib><creatorcontrib>Lee, Eun-So</creatorcontrib><creatorcontrib>Anower, A.K.M. 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Mostafa</au><au>Sohn, Seonghyang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CCL21 attenuates HSV-induced inflammation through up-regulation of CD8+ memory cells</atitle><jtitle>Immunobiology (1979)</jtitle><addtitle>Immunobiology</addtitle><date>2013-04-01</date><risdate>2013</risdate><volume>218</volume><issue>4</issue><spage>579</spage><epage>590</epage><pages>579-590</pages><issn>0171-2985</issn><eissn>1878-3279</eissn><abstract>Abstract CCR7 and its ligand, CCL21, are known to establish microenvironments for the initiation of immune responses in secondary lymphoid tissue. It has also been reported that CCR7 ligand gene-deleted mice have defects in lymphocyte homing. In addition, the injection of the CCR7 ligand was shown to induce the expression of memory T cells. In this study, we analyzed the expression of CCR7 and its ligand in HSV-induced Behçet's disease (BD)-like inflammation of mice. Additionally, plasmids containing the CCR7 ligand CCL19 or CCL21, pcDNA3.1-CCL19 or pcDNA3.1-CCL21, respectively, were injected into symptomatic mice, and changes in the population of memory T cells were determined. After administration of pcDNA3.1-CCL21, the frequencies of CD8+CD44+, CD8+CD62L− memory T cells were significantly up-regulated and the symptoms were not deteriorated when compared to the control vector injected group. Specifically, the difference in frequencies of CCR7+ peripheral blood mononuclear cells between active BD patients and inactive BD patients was similar to that of HSV-induced BD-like mice. These results suggest that CCR7, its ligand, and CD8+ memory cells are correlated with the regulation of BD symptoms.</abstract><cop>Netherlands</cop><pub>Elsevier GmbH</pub><pmid>22884357</pmid><doi>10.1016/j.imbio.2012.07.003</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0171-2985 |
| ispartof | Immunobiology (1979), 2013-04, Vol.218 (4), p.579-590 |
| issn | 0171-2985 1878-3279 |
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| subjects | Adult Advanced Basic Science Allergy and Immunology Animals Behcet Syndrome - genetics Behcet Syndrome - immunology Behcet Syndrome - pathology Behcet Syndrome - virology Behçet's disease CCL21 CCR7 CD8+ memory T cells CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology Cercopithecus aethiops Chemokine CCL21 - genetics Chemokine CCL21 - immunology Disease Models, Animal Female Herpes Simplex - genetics Herpes Simplex - immunology Herpes Simplex - pathology Herpes Simplex - virology Herpes simplex virus-induced inflammation Herpesvirus 1, Human - immunology Humans Immunologic Memory Inflammation - genetics Inflammation - immunology Inflammation - pathology Inflammation - virology Male Mice Mice, Inbred ICR Middle Aged Mouse model Receptors, CCR7 - genetics Receptors, CCR7 - immunology Up-Regulation - immunology Vero Cells |
| title | CCL21 attenuates HSV-induced inflammation through up-regulation of CD8+ memory cells |
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