Effects of MK-801 and amphetamine treatments on allergic lung inflammatory response in mice

Glutamate acts as a neurotransmitter within the Central Nervous System (CNS) and modifies immune cell activity. In lymphocytes, NMDA glutamate receptors regulate intracellular calcium, the production of reactive oxygen species and cytokine synthesis. MK-801, a NMDA receptor open-channel blocker, inh...

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Veröffentlicht in:	International immunopharmacology 2013-08, Vol.16 (4), p.436-443
Hauptverfasser:	Hamasato, Eduardo Kenji, Ligeiro de Oliveira, Ana Paula, Lino-dos-Santos-Franco, Adriana, Ribeiro, Alison, Ferraz de Paula, Viviane, Peron, Jean Pierre Schatzmann, Damazo, Amílcar Sabino, Tavares-de-Lima, Wothan, Palermo-Neto, João
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion molecules Allergic lung inflammation Amphetamine Amphetamine - administration & dosage Amphetamine - pharmacology Amphetamine - therapeutic use Animals Bone Marrow Cells - drug effects Bone Marrow Cells - immunology Bronchoalveolar Lavage Fluid - cytology Bronchoalveolar Lavage Fluid - immunology Cell Degranulation - drug effects Cell Degranulation - immunology Chemotaxis, Leukocyte - immunology Corticosterone - blood Corticosterone - immunology Cytokines Disease Models, Animal Dizocilpine Maleate - administration & dosage Dizocilpine Maleate - pharmacology HPA-axis Interleukins - immunology Leukocyte Count Male Mast Cells - drug effects Mast Cells - immunology Mast Cells - physiology Mice Mice, Inbred BALB C MK-801 Ovalbumin - immunology Pneumonia - immunology Pneumonia - metabolism Pneumonia - prevention & control Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Respiratory Hypersensitivity - immunology Respiratory Hypersensitivity - metabolism Respiratory Hypersensitivity - prevention & control
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