Metabolic engineering of Lactobacillus plantarum for succinic acid production through activation of the reductive branch of the tricarboxylic acid cycle

•Lactobacillus plantarum was used as a model as for succinic acid production.•We examined carbon fixation enzymes that improve metabolic flux.•We compared strains overexpressing or coexpressing carbon fixation enzymes.•One of the recombinant L. plantarum converts 25.3% of glucose to succinic acid.•T...

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Veröffentlicht in:	Enzyme and microbial technology 2013-07, Vol.53 (2), p.97-103
Hauptverfasser:	Tsuji, Akira, Okada, Sanae, Hols, Pascal, Satoh, Eiichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomass biosynthesis Citric Acid Cycle fungi glucose glycolysis hosts Industrial Microbiology lactic acid bacteria Lactobacillus plantarum Lactobacillus plantarum - genetics Lactobacillus plantarum - metabolism Malate Dehydrogenase - genetics Malate Dehydrogenase - metabolism Malic enzyme Metabolic engineering Metabolic Engineering - methods Phosphoenolpyruvate carboxykinase Phosphoenolpyruvate Carboxykinase (ATP) - genetics Phosphoenolpyruvate Carboxykinase (ATP) - metabolism Pyruvate carboxylase Pyruvate Carboxylase - genetics Pyruvate Carboxylase - metabolism Recombinant Proteins - genetics Recombinant Proteins - metabolism Succinic acid Succinic Acid - metabolism synthesis tricarboxylic acid cycle Up-Regulation
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