Small molecule ligands for enhanced intracellular delivery of lipid nanoparticle formulations of siRNA

Abstract Gene silencing activity of lipid nanoparticle (LNP) formulations of siRNA requires LNP surface factors promoting cellular uptake. This study aimed to identify small molecules that enhance cellular uptake of LNP siRNA systems, then use them as LNP-associated ligands to improve gene silencing...

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Veröffentlicht in:	Nanomedicine 2013-07, Vol.9 (5), p.665-674
Hauptverfasser:	Tam, Yuen Yi C., PhD, Chen, Sam, BSc, Zaifman, Josh, PhD, Tam, Ying K., PhD, Lin, Paulo J.C., PhD, Ansell, Steven, PhD, Roberge, Michel, PhD, Ciufolini, Marco A., PhD, Cullis, Pieter R., PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosinetriphosphatase Animals Cardiac glycosides Endocytosis - genetics Gene silencing Gene Silencing - drug effects Gene Transfer Techniques HeLa Cells High-throughput screening Humans Internal Medicine Ligands Lipid nanoparticle Lipids - administration & dosage Lipids - chemistry Nanoparticles - administration & dosage Nanoparticles - chemistry RNA, Small Interfering - chemistry RNA, Small Interfering - genetics siRNA Small molecule ligand Sodium-Potassium-Exchanging ATPase - genetics Sodium-Potassium-Exchanging ATPase - metabolism Strophanthidin - administration & dosage Strophanthidin - chemistry Targeted delivery Targeting
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