Correlation between gray matter volume in the temporal lobe and depressive symptoms in patients with Alzheimer's disease
Depressive symptoms may be associated with the volume changes of frontal and temporal lobe in patients with Alzheimer's disease. •Depression might be an aggravating factor in Alzheimer's disease.•Left inferior temporal volume was decreased in AD patients with depression.•Depressive symptom...
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| Veröffentlicht in: | Neuroscience letters 2013-08, Vol.548, p.15-20 |
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| creator | Son, Ji Hyun Han, Doug Hyun Min, Kyung Joon Kee, Baik Seok |
| description | Depressive symptoms may be associated with the volume changes of frontal and temporal lobe in patients with Alzheimer's disease.
•Depression might be an aggravating factor in Alzheimer's disease.•Left inferior temporal volume was decreased in AD patients with depression.•Depressive symptoms may accelerate cognitive decline and brain volume changes.
Recent studies have suggested that depression might be an aggravating factor in Alzheimer's disease (AD). The aim of the study was to compare depressive symptoms and gray matter volume between AD patients with comorbid depression and patients with dementia only. Forty-nine patients with AD, 57 with mild cognitive impairment (MCI), and 50 healthy control subjects were assessed using the Consortium to Establish a Registry for Alzheimer's disease (CERAD) and the Geriatric Depression Scale (GDS). All magnetic resonance imaging (MRI)s were analyzed using voxel-based morphometry (VBM). Seventeen AD patients with depression versus 32 patients with dementia only showed decreased immediate recall for a word list (8.7±1.1 vs. 10.1±1.5, z=3.6, p |
| doi_str_mv | 10.1016/j.neulet.2013.05.021 |
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•Depression might be an aggravating factor in Alzheimer's disease.•Left inferior temporal volume was decreased in AD patients with depression.•Depressive symptoms may accelerate cognitive decline and brain volume changes.
Recent studies have suggested that depression might be an aggravating factor in Alzheimer's disease (AD). The aim of the study was to compare depressive symptoms and gray matter volume between AD patients with comorbid depression and patients with dementia only. Forty-nine patients with AD, 57 with mild cognitive impairment (MCI), and 50 healthy control subjects were assessed using the Consortium to Establish a Registry for Alzheimer's disease (CERAD) and the Geriatric Depression Scale (GDS). All magnetic resonance imaging (MRI)s were analyzed using voxel-based morphometry (VBM). Seventeen AD patients with depression versus 32 patients with dementia only showed decreased immediate recall for a word list (8.7±1.1 vs. 10.1±1.5, z=3.6, p<0.01) and constructional praxis scores (3.7±0.9 vs. 5.3±2.1, z=2.5, p=0.01). Compared to 32 patients with dementia, seventeen AD patients with depression showed decreased gray matter volume in the left inferior temporal gyrus (−56, −19, −31; KE=578, t=3.80, Puncorr<0.001). The MCI group showed decreased gray matter volume in the right hippocampal gyrus compared to healthy control group. Our results suggest that depressive symptoms may be associated with the volume changes of frontal and temporal lobe in patients with AD.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2013.05.021</identifier><identifier>PMID: 23727389</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Aged ; Aged, 80 and over ; Alzheimer Disease - complications ; Alzheimer Disease - diagnosis ; Alzheimer's disease (AD) ; Consortium to Establish a Registry for Alzheimer's disease (CERAD) ; Depression - complications ; Depression - diagnosis ; Female ; Frontal Lobe - pathology ; Geriatric Depression Scale (GDS) ; Humans ; Imaging, Three-Dimensional - methods ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Neurons - pathology ; Organ Size ; Reproducibility of Results ; Sensitivity and Specificity ; Temporal Lobe - pathology ; Voxel based morphometry (VBM)</subject><ispartof>Neuroscience letters, 2013-08, Vol.548, p.15-20</ispartof><rights>2013 Elsevier Ireland Ltd</rights><rights>Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c395t-eb8faa05009cb87493846d8b01c04c4fc57e5bece25da275568eab1b043bfb163</citedby><cites>FETCH-LOGICAL-c395t-eb8faa05009cb87493846d8b01c04c4fc57e5bece25da275568eab1b043bfb163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304394013004424$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23727389$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Son, Ji Hyun</creatorcontrib><creatorcontrib>Han, Doug Hyun</creatorcontrib><creatorcontrib>Min, Kyung Joon</creatorcontrib><creatorcontrib>Kee, Baik Seok</creatorcontrib><title>Correlation between gray matter volume in the temporal lobe and depressive symptoms in patients with Alzheimer's disease</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Depressive symptoms may be associated with the volume changes of frontal and temporal lobe in patients with Alzheimer's disease.
•Depression might be an aggravating factor in Alzheimer's disease.•Left inferior temporal volume was decreased in AD patients with depression.•Depressive symptoms may accelerate cognitive decline and brain volume changes.
Recent studies have suggested that depression might be an aggravating factor in Alzheimer's disease (AD). The aim of the study was to compare depressive symptoms and gray matter volume between AD patients with comorbid depression and patients with dementia only. Forty-nine patients with AD, 57 with mild cognitive impairment (MCI), and 50 healthy control subjects were assessed using the Consortium to Establish a Registry for Alzheimer's disease (CERAD) and the Geriatric Depression Scale (GDS). All magnetic resonance imaging (MRI)s were analyzed using voxel-based morphometry (VBM). Seventeen AD patients with depression versus 32 patients with dementia only showed decreased immediate recall for a word list (8.7±1.1 vs. 10.1±1.5, z=3.6, p<0.01) and constructional praxis scores (3.7±0.9 vs. 5.3±2.1, z=2.5, p=0.01). Compared to 32 patients with dementia, seventeen AD patients with depression showed decreased gray matter volume in the left inferior temporal gyrus (−56, −19, −31; KE=578, t=3.80, Puncorr<0.001). The MCI group showed decreased gray matter volume in the right hippocampal gyrus compared to healthy control group. Our results suggest that depressive symptoms may be associated with the volume changes of frontal and temporal lobe in patients with AD.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - complications</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Alzheimer's disease (AD)</subject><subject>Consortium to Establish a Registry for Alzheimer's disease (CERAD)</subject><subject>Depression - complications</subject><subject>Depression - diagnosis</subject><subject>Female</subject><subject>Frontal Lobe - pathology</subject><subject>Geriatric Depression Scale (GDS)</subject><subject>Humans</subject><subject>Imaging, Three-Dimensional - methods</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neurons - pathology</subject><subject>Organ Size</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Temporal Lobe - pathology</subject><subject>Voxel based morphometry (VBM)</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcGO0zAURS0EYjoDf4CQd7BJeE7sOtkgjSoYkEZiA2vLdl6oKycOttOhfD2uOrCE1ducd690DyGvGNQM2PbdoZ5x9ZjrBlhbg6ihYU_IhnWyqWQvm6dkAy3wqu05XJHrlA4AIJjgz8lV08pGtl2_IT93IUb0OrswU4P5AXGm36M-0UnnjJEeg18npG6meY8047SEqD31wSDV80AHXCKm5I5I02lacpjSGV5KIs450QeX9_TW_9qjmzC-SXRwCXXCF-TZqH3Cl4_3hnz7-OHr7lN1_-Xu8-72vrJtL3KFphu1BgHQW9NJ3rcd3w6dAWaBWz5aIVEYtNiIQTdSiG2H2jADvDWjYdv2hry95C4x_FgxZTW5ZNF7PWNYk2IlWkredfz_KAfgwMqIBeUX1MaQUsRRLdFNOp4UA3XWow7qoked9SgQqugpb68fG1Yz4fD36Y-PAry_AFgmOTqMKtmyo8XBRbRZDcH9u-E3Uj-lIA</recordid><startdate>20130826</startdate><enddate>20130826</enddate><creator>Son, Ji Hyun</creator><creator>Han, Doug Hyun</creator><creator>Min, Kyung Joon</creator><creator>Kee, Baik Seok</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20130826</creationdate><title>Correlation between gray matter volume in the temporal lobe and depressive symptoms in patients with Alzheimer's disease</title><author>Son, Ji Hyun ; Han, Doug Hyun ; Min, Kyung Joon ; Kee, Baik Seok</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c395t-eb8faa05009cb87493846d8b01c04c4fc57e5bece25da275568eab1b043bfb163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - complications</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Alzheimer's disease (AD)</topic><topic>Consortium to Establish a Registry for Alzheimer's disease (CERAD)</topic><topic>Depression - complications</topic><topic>Depression - diagnosis</topic><topic>Female</topic><topic>Frontal Lobe - pathology</topic><topic>Geriatric Depression Scale (GDS)</topic><topic>Humans</topic><topic>Imaging, Three-Dimensional - methods</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neurons - pathology</topic><topic>Organ Size</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Temporal Lobe - pathology</topic><topic>Voxel based morphometry (VBM)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Son, Ji Hyun</creatorcontrib><creatorcontrib>Han, Doug Hyun</creatorcontrib><creatorcontrib>Min, Kyung Joon</creatorcontrib><creatorcontrib>Kee, Baik Seok</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Son, Ji Hyun</au><au>Han, Doug Hyun</au><au>Min, Kyung Joon</au><au>Kee, Baik Seok</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between gray matter volume in the temporal lobe and depressive symptoms in patients with Alzheimer's disease</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2013-08-26</date><risdate>2013</risdate><volume>548</volume><spage>15</spage><epage>20</epage><pages>15-20</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><abstract>Depressive symptoms may be associated with the volume changes of frontal and temporal lobe in patients with Alzheimer's disease.
•Depression might be an aggravating factor in Alzheimer's disease.•Left inferior temporal volume was decreased in AD patients with depression.•Depressive symptoms may accelerate cognitive decline and brain volume changes.
Recent studies have suggested that depression might be an aggravating factor in Alzheimer's disease (AD). The aim of the study was to compare depressive symptoms and gray matter volume between AD patients with comorbid depression and patients with dementia only. Forty-nine patients with AD, 57 with mild cognitive impairment (MCI), and 50 healthy control subjects were assessed using the Consortium to Establish a Registry for Alzheimer's disease (CERAD) and the Geriatric Depression Scale (GDS). All magnetic resonance imaging (MRI)s were analyzed using voxel-based morphometry (VBM). Seventeen AD patients with depression versus 32 patients with dementia only showed decreased immediate recall for a word list (8.7±1.1 vs. 10.1±1.5, z=3.6, p<0.01) and constructional praxis scores (3.7±0.9 vs. 5.3±2.1, z=2.5, p=0.01). Compared to 32 patients with dementia, seventeen AD patients with depression showed decreased gray matter volume in the left inferior temporal gyrus (−56, −19, −31; KE=578, t=3.80, Puncorr<0.001). The MCI group showed decreased gray matter volume in the right hippocampal gyrus compared to healthy control group. Our results suggest that depressive symptoms may be associated with the volume changes of frontal and temporal lobe in patients with AD.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>23727389</pmid><doi>10.1016/j.neulet.2013.05.021</doi><tpages>6</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Alzheimer Disease - complications Alzheimer Disease - diagnosis Alzheimer's disease (AD) Consortium to Establish a Registry for Alzheimer's disease (CERAD) Depression - complications Depression - diagnosis Female Frontal Lobe - pathology Geriatric Depression Scale (GDS) Humans Imaging, Three-Dimensional - methods Magnetic Resonance Imaging - methods Male Middle Aged Neurons - pathology Organ Size Reproducibility of Results Sensitivity and Specificity Temporal Lobe - pathology Voxel based morphometry (VBM) |
| title | Correlation between gray matter volume in the temporal lobe and depressive symptoms in patients with Alzheimer's disease |
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