White matter microstructural damage in Alzheimer's disease at different ages of onset
Abstract White matter (WM) microstructural damage and its relationship with cortical abnormalities were explored in early-onset Alzheimer's disease (EOAD) compared with late-onset AD (LOAD) patients. Structural and diffusion tensor magnetic resonance images were obtained from 22 EOAD patients,...
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| Veröffentlicht in: | Neurobiology of aging 2013-10, Vol.34 (10), p.2331-2340 |
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| creator | Canu, Elisa Agosta, Federica Spinelli, Edoardo G Magnani, Giuseppe Marcone, Alessandra Scola, Elisa Falautano, Monica Comi, Giancarlo Falini, Andrea Filippi, Massimo |
| description | Abstract White matter (WM) microstructural damage and its relationship with cortical abnormalities were explored in early-onset Alzheimer's disease (EOAD) compared with late-onset AD (LOAD) patients. Structural and diffusion tensor magnetic resonance images were obtained from 22 EOAD patients, 35 LOAD patients, and 40 healthy controls. Patterns of WM microstructural damage and cortical atrophy, as well as their relationships, were assessed using tract-based spatial statistics, tractography and voxel-based morphometry. Compared with LOAD, EOAD patients had a more severe and distributed pattern of WM microstructural damage, in particular in the posterior fibers of cingulum and corpus callosum. In both groups with Alzheimer's disease, but especially in LOAD patients, correlations between cingulum and corpus callosum fractional anisotropy and parietal, temporal, and frontal cortical volumes were found. In conclusion, WM microstructural damage is more severe in EOAD compared with LOAD patients. Such damage follows different patterns of topographical distribution in the 2 patient groups. |
| doi_str_mv | 10.1016/j.neurobiolaging.2013.03.026 |
| format | Article |
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Structural and diffusion tensor magnetic resonance images were obtained from 22 EOAD patients, 35 LOAD patients, and 40 healthy controls. Patterns of WM microstructural damage and cortical atrophy, as well as their relationships, were assessed using tract-based spatial statistics, tractography and voxel-based morphometry. Compared with LOAD, EOAD patients had a more severe and distributed pattern of WM microstructural damage, in particular in the posterior fibers of cingulum and corpus callosum. In both groups with Alzheimer's disease, but especially in LOAD patients, correlations between cingulum and corpus callosum fractional anisotropy and parietal, temporal, and frontal cortical volumes were found. In conclusion, WM microstructural damage is more severe in EOAD compared with LOAD patients. Such damage follows different patterns of topographical distribution in the 2 patient groups.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/j.neurobiolaging.2013.03.026</identifier><identifier>PMID: 23623599</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Age ; Age of Onset ; Aged ; Aged, 80 and over ; Alzheimer Disease - epidemiology ; Alzheimer Disease - pathology ; Brain Mapping ; Cerebral Cortex - pathology ; Corpus Callosum - pathology ; Diffusion Magnetic Resonance Imaging - methods ; Diffusion Tensor Imaging ; Diffusion tensor MRI ; Early-onset Alzheimer's disease ; Female ; Gyrus Cinguli - pathology ; Humans ; Internal Medicine ; Late-onset Alzheimer's disease ; Male ; Middle Aged ; MRI ; Neurology ; Severity of Illness Index ; White matter damage</subject><ispartof>Neurobiology of aging, 2013-10, Vol.34 (10), p.2331-2340</ispartof><rights>Elsevier Inc.</rights><rights>2013 Elsevier Inc.</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-dcb19adafccb597e31bc6334b517f23f7ae7b1985363d7342b11101e9a6aed363</citedby><cites>FETCH-LOGICAL-c507t-dcb19adafccb597e31bc6334b517f23f7ae7b1985363d7342b11101e9a6aed363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neurobiolaging.2013.03.026$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23623599$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Canu, Elisa</creatorcontrib><creatorcontrib>Agosta, Federica</creatorcontrib><creatorcontrib>Spinelli, Edoardo G</creatorcontrib><creatorcontrib>Magnani, Giuseppe</creatorcontrib><creatorcontrib>Marcone, Alessandra</creatorcontrib><creatorcontrib>Scola, Elisa</creatorcontrib><creatorcontrib>Falautano, Monica</creatorcontrib><creatorcontrib>Comi, Giancarlo</creatorcontrib><creatorcontrib>Falini, Andrea</creatorcontrib><creatorcontrib>Filippi, Massimo</creatorcontrib><title>White matter microstructural damage in Alzheimer's disease at different ages of onset</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>Abstract White matter (WM) microstructural damage and its relationship with cortical abnormalities were explored in early-onset Alzheimer's disease (EOAD) compared with late-onset AD (LOAD) patients. Structural and diffusion tensor magnetic resonance images were obtained from 22 EOAD patients, 35 LOAD patients, and 40 healthy controls. Patterns of WM microstructural damage and cortical atrophy, as well as their relationships, were assessed using tract-based spatial statistics, tractography and voxel-based morphometry. Compared with LOAD, EOAD patients had a more severe and distributed pattern of WM microstructural damage, in particular in the posterior fibers of cingulum and corpus callosum. In both groups with Alzheimer's disease, but especially in LOAD patients, correlations between cingulum and corpus callosum fractional anisotropy and parietal, temporal, and frontal cortical volumes were found. In conclusion, WM microstructural damage is more severe in EOAD compared with LOAD patients. Such damage follows different patterns of topographical distribution in the 2 patient groups.</description><subject>Age</subject><subject>Age of Onset</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - epidemiology</subject><subject>Alzheimer Disease - pathology</subject><subject>Brain Mapping</subject><subject>Cerebral Cortex - pathology</subject><subject>Corpus Callosum - pathology</subject><subject>Diffusion Magnetic Resonance Imaging - methods</subject><subject>Diffusion Tensor Imaging</subject><subject>Diffusion tensor MRI</subject><subject>Early-onset Alzheimer's disease</subject><subject>Female</subject><subject>Gyrus Cinguli - pathology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Late-onset Alzheimer's disease</subject><subject>Male</subject><subject>Middle Aged</subject><subject>MRI</subject><subject>Neurology</subject><subject>Severity of Illness Index</subject><subject>White matter damage</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkl1rFDEUhoModrv6FyQXgt7MNh-TyQZEKMVWoeBFW7wMmeTMNutMUpOMUH-9GbYK9qaGAzmEJ-ck73sQekvJhhLanew3AeYUex9Hs_Nht2GE8g2pwbpnaEWF2Da0VfI5WhGqZNOKLTlCxznvCSGyld1LdMR4x7hQaoVuvt36AngypUDCk7cp5pJmW-ZkRuzMZHaAfcCn469b8BOkdxk7n8FkwKbUdBggQSi4chnHAceQobxCLwYzZnj9sK_Rzfmn67PPzeXXiy9np5eNFUSWxtmeKuPMYG0vlAROe9tx3vaCyoHxQRqQldgK3nEnect6SqsGoExnwNXDNXp_qHuX4o8ZctGTzxbG0QSIc9ZU1C9LvlX0abRlsgpJePs0ypUiQvK61ujDAV10ywkGfZf8ZNK9pkQvdum9_tcuvdilSQ22vP_NQ6e5n8D9vfzHnwqcHwCoKv70kHS2HoIF5xPYol30_9vp46NCdvTBWzN-h3vI-zinUJ3SVGemib5aRmeZnKoIoa0g_De0iMOf</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>Canu, Elisa</creator><creator>Agosta, Federica</creator><creator>Spinelli, Edoardo G</creator><creator>Magnani, Giuseppe</creator><creator>Marcone, Alessandra</creator><creator>Scola, Elisa</creator><creator>Falautano, Monica</creator><creator>Comi, Giancarlo</creator><creator>Falini, Andrea</creator><creator>Filippi, Massimo</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20131001</creationdate><title>White matter microstructural damage in Alzheimer's disease at different ages of onset</title><author>Canu, Elisa ; Agosta, Federica ; Spinelli, Edoardo G ; Magnani, Giuseppe ; Marcone, Alessandra ; Scola, Elisa ; Falautano, Monica ; Comi, Giancarlo ; Falini, Andrea ; Filippi, Massimo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-dcb19adafccb597e31bc6334b517f23f7ae7b1985363d7342b11101e9a6aed363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Age</topic><topic>Age of Onset</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - epidemiology</topic><topic>Alzheimer Disease - pathology</topic><topic>Brain Mapping</topic><topic>Cerebral Cortex - pathology</topic><topic>Corpus Callosum - pathology</topic><topic>Diffusion Magnetic Resonance Imaging - methods</topic><topic>Diffusion Tensor Imaging</topic><topic>Diffusion tensor MRI</topic><topic>Early-onset Alzheimer's disease</topic><topic>Female</topic><topic>Gyrus Cinguli - pathology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Late-onset Alzheimer's disease</topic><topic>Male</topic><topic>Middle Aged</topic><topic>MRI</topic><topic>Neurology</topic><topic>Severity of Illness Index</topic><topic>White matter damage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Canu, Elisa</creatorcontrib><creatorcontrib>Agosta, Federica</creatorcontrib><creatorcontrib>Spinelli, Edoardo G</creatorcontrib><creatorcontrib>Magnani, Giuseppe</creatorcontrib><creatorcontrib>Marcone, Alessandra</creatorcontrib><creatorcontrib>Scola, Elisa</creatorcontrib><creatorcontrib>Falautano, Monica</creatorcontrib><creatorcontrib>Comi, Giancarlo</creatorcontrib><creatorcontrib>Falini, Andrea</creatorcontrib><creatorcontrib>Filippi, Massimo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Canu, Elisa</au><au>Agosta, Federica</au><au>Spinelli, Edoardo G</au><au>Magnani, Giuseppe</au><au>Marcone, Alessandra</au><au>Scola, Elisa</au><au>Falautano, Monica</au><au>Comi, Giancarlo</au><au>Falini, Andrea</au><au>Filippi, Massimo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>White matter microstructural damage in Alzheimer's disease at different ages of onset</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>2013-10-01</date><risdate>2013</risdate><volume>34</volume><issue>10</issue><spage>2331</spage><epage>2340</epage><pages>2331-2340</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><abstract>Abstract White matter (WM) microstructural damage and its relationship with cortical abnormalities were explored in early-onset Alzheimer's disease (EOAD) compared with late-onset AD (LOAD) patients. Structural and diffusion tensor magnetic resonance images were obtained from 22 EOAD patients, 35 LOAD patients, and 40 healthy controls. Patterns of WM microstructural damage and cortical atrophy, as well as their relationships, were assessed using tract-based spatial statistics, tractography and voxel-based morphometry. Compared with LOAD, EOAD patients had a more severe and distributed pattern of WM microstructural damage, in particular in the posterior fibers of cingulum and corpus callosum. In both groups with Alzheimer's disease, but especially in LOAD patients, correlations between cingulum and corpus callosum fractional anisotropy and parietal, temporal, and frontal cortical volumes were found. In conclusion, WM microstructural damage is more severe in EOAD compared with LOAD patients. 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| subjects | Age Age of Onset Aged Aged, 80 and over Alzheimer Disease - epidemiology Alzheimer Disease - pathology Brain Mapping Cerebral Cortex - pathology Corpus Callosum - pathology Diffusion Magnetic Resonance Imaging - methods Diffusion Tensor Imaging Diffusion tensor MRI Early-onset Alzheimer's disease Female Gyrus Cinguli - pathology Humans Internal Medicine Late-onset Alzheimer's disease Male Middle Aged MRI Neurology Severity of Illness Index White matter damage |
| title | White matter microstructural damage in Alzheimer's disease at different ages of onset |
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