Reduced neuroplasticity in aged rats: a role for the neurotrophin brain-derived neurotrophic factor

Abstract Aging is a physiological process characterized by a significant reduction of neuronal plasticity that might contribute to the functional defects observed in old subjects. Even if the neurobiological mechanisms that contribute to such impairment remain largely unknown, a role for neurotrophi...

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Veröffentlicht in:	Neurobiology of aging 2013-12, Vol.34 (12), p.2768-2776
Hauptverfasser:	Calabrese, Francesca, Guidotti, Gianluigi, Racagni, Giorgio, Riva, Marco A
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging Aging - genetics Aging - physiology Animals BDNF Brain - metabolism Brain-Derived Neurotrophic Factor - metabolism Brain-Derived Neurotrophic Factor - physiology Carf Cognition Cognition Disorders - drug therapy Cognition Disorders - etiology Creb Cyclic AMP Response Element-Binding Protein - physiology Internal Medicine Male Molecular Targeted Therapy Neurology Neuronal Plasticity - physiology Npas4 Protein Biosynthesis - genetics Rats Rats, Wistar Receptor, trkB - physiology Transcription factors Transcription Factors - physiology Transcription, Genetic - genetics TrkB
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