Decationized crosslinked polyplexes for redox-triggered gene delivery

The clinical applicability of polymers as gene delivery systems depends not only on their efficiency, but also on their safety. The cytotoxicity of these systems remains a major issue, mainly due to their cationic nature. Therefore, it is highly preferable to have a system based on biocompatible neu...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of controlled release 2013-08, Vol.169 (3), p.246-256
Hauptverfasser:	Novo, Luís, van Gaal, Ethlinn V.B., Mastrobattista, Enrico, van Nostrum, Cornelus F., Hennink, Wim E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamides - chemistry Acrylamides - toxicity Biocompatibility cations Cations - chemistry Cations - toxicity Cell Survival - drug effects cell viability Condensation crosslinking cytosol cytotoxicity Disulfides - chemistry Disulfides - toxicity DNA - administration & dosage DNA - genetics electroporation ethylene glycol Gene delivery gene expression Gene Transfer Techniques HeLa Cells Humans Nanoparticle nanoparticles Oxidation-Reduction plasmids Plasmids - administration & dosage Plasmids - genetics Polyethylene Glycols - chemistry Polyethylene Glycols - toxicity Polymer polymers reporter genes therapeutics Triggered release
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!