Feasibility of ASL-based phMRI with a single dose of oral citalopram for repeated assessment of serotonin function
Assessment of cerebral serotonin (5-HT) function with arterial spin labeling (ASL)-based pharmacological magnetic resonance imaging (phMRI) could be a highly useful tool in clinical psychiatric research. The goal of this study was to verify the reliability of ASL-based phMRI after an oral challenge...
Gespeichert in:
| Veröffentlicht in: | NeuroImage (Orlando, Fla.) Fla.), 2012-11, Vol.63 (3), p.1695-1700 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1700 |
|---|---|
| container_issue | 3 |
| container_start_page | 1695 |
| container_title | NeuroImage (Orlando, Fla.) |
| container_volume | 63 |
| creator | Klomp, A. Caan, M.W.A. Denys, D. Nederveen, A.J. Reneman, L. |
| description | Assessment of cerebral serotonin (5-HT) function with arterial spin labeling (ASL)-based pharmacological magnetic resonance imaging (phMRI) could be a highly useful tool in clinical psychiatric research. The goal of this study was to verify the reliability of ASL-based phMRI after an oral challenge of a selective serotonin reuptake inhibitor (SSRI) in repeated assessment of cerebral 5-HT function. In a placebo-controlled, within-subject crossover study we investigated the effect of a single oral dose of citalopram on brain cerebral blood flow (CBF) using a pulsed ASL sequence (PASL) in twelve female healthy volunteers. The within-session repeatability of the PASL signal was good for all regions tested (wsCV |
| doi_str_mv | 10.1016/j.neuroimage.2012.07.038 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1500770690</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1053811912007677</els_id><sourcerecordid>3245072971</sourcerecordid><originalsourceid>FETCH-LOGICAL-c435t-45e937d8feeb81ea56b1d2985be757b4a9db53de3e9a553a2b4c357ba4155d593</originalsourceid><addsrcrecordid>eNqFkUtv1TAQRiMEoqXwF5AlNmwS_Ihje1kq-pAuQqJlbTnxpPVVYgfbKeq_r6NbQOqmq7E055vR-FQVIrghmHRf9o2HNQY3m1toKCa0waLBTL6qjglWvFZc0Nfbm7NaEqKOqncp7THGirTybXVEqWwpJfS4iudgkuvd5PIDCiM6vd7VvUlg0XL3_ecV-uPyHTIoOX87AbIhwUaFaCY0uGymsEQzozFEFGEBk0vQpAQpzeDzhiaIIQfvPBpXP2QX_PvqzWimBB-e6kn16_zbzdllvftxcXV2uquHlvFctxwUE1aOAL0kYHjXE0uV5D0ILvrWKNtzZoGBMpwzQ_t2YKVhWsK55YqdVJ8Pc5cYfq-Qsp5dGmCajIewJk04xkLgTuGXUUIoazkToqCfnqH7sEZfDtkGdlJ2gpNCyQM1xJBShFEvsdiKD5pgvSnUe_1fod4Uaix0UViiH58WrP0M9l_wr7MCfD0AUD7v3kHUaXDgB7AuwpC1De7lLY_R-rI_</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1506886751</pqid></control><display><type>article</type><title>Feasibility of ASL-based phMRI with a single dose of oral citalopram for repeated assessment of serotonin function</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Klomp, A. ; Caan, M.W.A. ; Denys, D. ; Nederveen, A.J. ; Reneman, L.</creator><creatorcontrib>Klomp, A. ; Caan, M.W.A. ; Denys, D. ; Nederveen, A.J. ; Reneman, L.</creatorcontrib><description>Assessment of cerebral serotonin (5-HT) function with arterial spin labeling (ASL)-based pharmacological magnetic resonance imaging (phMRI) could be a highly useful tool in clinical psychiatric research. The goal of this study was to verify the reliability of ASL-based phMRI after an oral challenge of a selective serotonin reuptake inhibitor (SSRI) in repeated assessment of cerebral 5-HT function. In a placebo-controlled, within-subject crossover study we investigated the effect of a single oral dose of citalopram on brain cerebral blood flow (CBF) using a pulsed ASL sequence (PASL) in twelve female healthy volunteers. The within-session repeatability of the PASL signal was good for all regions tested (wsCV<15%). Both ROI- and voxel-based analyses revealed small but significant effects of a citalopram challenge on CBF values in 5-HT rich brain regions, among which the frontal gyrus and thalamus. These effects could however not be replicated between sessions, most probably due to the small effect size of the oral citalopram challenge on cerebral blood flow. We therefore conclude that the test–retest reliability of PASL phMRI with an oral citalopram challenge is low, limiting the technique's sensitivity to time-dependent changes and consequently its use as a (clinical) research tool.
► Non-invasive assessment of 5-HT function will be valuable in psychiatric research. ► phMRI with a 5-HT challenge can be used as a marker for central 5-HT function. ► We assessed test-retest reliability of PASL-based phMRI with an oral SSRI challenge. ► Effects of citalopram on CBF were small and could not be replicated over sessions. ► Low test-retest reliability of the here-tested technique limits its use as research tool.</description><identifier>ISSN: 1053-8119</identifier><identifier>EISSN: 1095-9572</identifier><identifier>DOI: 10.1016/j.neuroimage.2012.07.038</identifier><identifier>PMID: 22842212</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>5-HT ; Adult ; Arterial spin labeling ; Brain ; Brain - metabolism ; Brain research ; Citalopram ; Confidence intervals ; Feasibility Studies ; Female ; Humans ; Image Interpretation, Computer-Assisted ; Magnetic Resonance Imaging - methods ; Medical imaging ; Pharmacological MRI ; Repeatability ; Reproducibility of Results ; Serotonin - analysis ; Serotonin - metabolism ; Serotonin Uptake Inhibitors ; Single-Blind Method ; Spin Labels ; SSRIs ; Studies ; Young Adult</subject><ispartof>NeuroImage (Orlando, Fla.), 2012-11, Vol.63 (3), p.1695-1700</ispartof><rights>2012 Elsevier Inc.</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Nov 15, 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-45e937d8feeb81ea56b1d2985be757b4a9db53de3e9a553a2b4c357ba4155d593</citedby><cites>FETCH-LOGICAL-c435t-45e937d8feeb81ea56b1d2985be757b4a9db53de3e9a553a2b4c357ba4155d593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1053811912007677$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22842212$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Klomp, A.</creatorcontrib><creatorcontrib>Caan, M.W.A.</creatorcontrib><creatorcontrib>Denys, D.</creatorcontrib><creatorcontrib>Nederveen, A.J.</creatorcontrib><creatorcontrib>Reneman, L.</creatorcontrib><title>Feasibility of ASL-based phMRI with a single dose of oral citalopram for repeated assessment of serotonin function</title><title>NeuroImage (Orlando, Fla.)</title><addtitle>Neuroimage</addtitle><description>Assessment of cerebral serotonin (5-HT) function with arterial spin labeling (ASL)-based pharmacological magnetic resonance imaging (phMRI) could be a highly useful tool in clinical psychiatric research. The goal of this study was to verify the reliability of ASL-based phMRI after an oral challenge of a selective serotonin reuptake inhibitor (SSRI) in repeated assessment of cerebral 5-HT function. In a placebo-controlled, within-subject crossover study we investigated the effect of a single oral dose of citalopram on brain cerebral blood flow (CBF) using a pulsed ASL sequence (PASL) in twelve female healthy volunteers. The within-session repeatability of the PASL signal was good for all regions tested (wsCV<15%). Both ROI- and voxel-based analyses revealed small but significant effects of a citalopram challenge on CBF values in 5-HT rich brain regions, among which the frontal gyrus and thalamus. These effects could however not be replicated between sessions, most probably due to the small effect size of the oral citalopram challenge on cerebral blood flow. We therefore conclude that the test–retest reliability of PASL phMRI with an oral citalopram challenge is low, limiting the technique's sensitivity to time-dependent changes and consequently its use as a (clinical) research tool.
► Non-invasive assessment of 5-HT function will be valuable in psychiatric research. ► phMRI with a 5-HT challenge can be used as a marker for central 5-HT function. ► We assessed test-retest reliability of PASL-based phMRI with an oral SSRI challenge. ► Effects of citalopram on CBF were small and could not be replicated over sessions. ► Low test-retest reliability of the here-tested technique limits its use as research tool.</description><subject>5-HT</subject><subject>Adult</subject><subject>Arterial spin labeling</subject><subject>Brain</subject><subject>Brain - metabolism</subject><subject>Brain research</subject><subject>Citalopram</subject><subject>Confidence intervals</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Medical imaging</subject><subject>Pharmacological MRI</subject><subject>Repeatability</subject><subject>Reproducibility of Results</subject><subject>Serotonin - analysis</subject><subject>Serotonin - metabolism</subject><subject>Serotonin Uptake Inhibitors</subject><subject>Single-Blind Method</subject><subject>Spin Labels</subject><subject>SSRIs</subject><subject>Studies</subject><subject>Young Adult</subject><issn>1053-8119</issn><issn>1095-9572</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkUtv1TAQRiMEoqXwF5AlNmwS_Ihje1kq-pAuQqJlbTnxpPVVYgfbKeq_r6NbQOqmq7E055vR-FQVIrghmHRf9o2HNQY3m1toKCa0waLBTL6qjglWvFZc0Nfbm7NaEqKOqncp7THGirTybXVEqWwpJfS4iudgkuvd5PIDCiM6vd7VvUlg0XL3_ecV-uPyHTIoOX87AbIhwUaFaCY0uGymsEQzozFEFGEBk0vQpAQpzeDzhiaIIQfvPBpXP2QX_PvqzWimBB-e6kn16_zbzdllvftxcXV2uquHlvFctxwUE1aOAL0kYHjXE0uV5D0ILvrWKNtzZoGBMpwzQ_t2YKVhWsK55YqdVJ8Pc5cYfq-Qsp5dGmCajIewJk04xkLgTuGXUUIoazkToqCfnqH7sEZfDtkGdlJ2gpNCyQM1xJBShFEvsdiKD5pgvSnUe_1fod4Uaix0UViiH58WrP0M9l_wr7MCfD0AUD7v3kHUaXDgB7AuwpC1De7lLY_R-rI_</recordid><startdate>20121115</startdate><enddate>20121115</enddate><creator>Klomp, A.</creator><creator>Caan, M.W.A.</creator><creator>Denys, D.</creator><creator>Nederveen, A.J.</creator><creator>Reneman, L.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>P64</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>7QO</scope></search><sort><creationdate>20121115</creationdate><title>Feasibility of ASL-based phMRI with a single dose of oral citalopram for repeated assessment of serotonin function</title><author>Klomp, A. ; Caan, M.W.A. ; Denys, D. ; Nederveen, A.J. ; Reneman, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-45e937d8feeb81ea56b1d2985be757b4a9db53de3e9a553a2b4c357ba4155d593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>5-HT</topic><topic>Adult</topic><topic>Arterial spin labeling</topic><topic>Brain</topic><topic>Brain - metabolism</topic><topic>Brain research</topic><topic>Citalopram</topic><topic>Confidence intervals</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Image Interpretation, Computer-Assisted</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Medical imaging</topic><topic>Pharmacological MRI</topic><topic>Repeatability</topic><topic>Reproducibility of Results</topic><topic>Serotonin - analysis</topic><topic>Serotonin - metabolism</topic><topic>Serotonin Uptake Inhibitors</topic><topic>Single-Blind Method</topic><topic>Spin Labels</topic><topic>SSRIs</topic><topic>Studies</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klomp, A.</creatorcontrib><creatorcontrib>Caan, M.W.A.</creatorcontrib><creatorcontrib>Denys, D.</creatorcontrib><creatorcontrib>Nederveen, A.J.</creatorcontrib><creatorcontrib>Reneman, L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><jtitle>NeuroImage (Orlando, Fla.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klomp, A.</au><au>Caan, M.W.A.</au><au>Denys, D.</au><au>Nederveen, A.J.</au><au>Reneman, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Feasibility of ASL-based phMRI with a single dose of oral citalopram for repeated assessment of serotonin function</atitle><jtitle>NeuroImage (Orlando, Fla.)</jtitle><addtitle>Neuroimage</addtitle><date>2012-11-15</date><risdate>2012</risdate><volume>63</volume><issue>3</issue><spage>1695</spage><epage>1700</epage><pages>1695-1700</pages><issn>1053-8119</issn><eissn>1095-9572</eissn><abstract>Assessment of cerebral serotonin (5-HT) function with arterial spin labeling (ASL)-based pharmacological magnetic resonance imaging (phMRI) could be a highly useful tool in clinical psychiatric research. The goal of this study was to verify the reliability of ASL-based phMRI after an oral challenge of a selective serotonin reuptake inhibitor (SSRI) in repeated assessment of cerebral 5-HT function. In a placebo-controlled, within-subject crossover study we investigated the effect of a single oral dose of citalopram on brain cerebral blood flow (CBF) using a pulsed ASL sequence (PASL) in twelve female healthy volunteers. The within-session repeatability of the PASL signal was good for all regions tested (wsCV<15%). Both ROI- and voxel-based analyses revealed small but significant effects of a citalopram challenge on CBF values in 5-HT rich brain regions, among which the frontal gyrus and thalamus. These effects could however not be replicated between sessions, most probably due to the small effect size of the oral citalopram challenge on cerebral blood flow. We therefore conclude that the test–retest reliability of PASL phMRI with an oral citalopram challenge is low, limiting the technique's sensitivity to time-dependent changes and consequently its use as a (clinical) research tool.
► Non-invasive assessment of 5-HT function will be valuable in psychiatric research. ► phMRI with a 5-HT challenge can be used as a marker for central 5-HT function. ► We assessed test-retest reliability of PASL-based phMRI with an oral SSRI challenge. ► Effects of citalopram on CBF were small and could not be replicated over sessions. ► Low test-retest reliability of the here-tested technique limits its use as research tool.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>22842212</pmid><doi>10.1016/j.neuroimage.2012.07.038</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1053-8119 |
| ispartof | NeuroImage (Orlando, Fla.), 2012-11, Vol.63 (3), p.1695-1700 |
| issn | 1053-8119 1095-9572 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1500770690 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | 5-HT Adult Arterial spin labeling Brain Brain - metabolism Brain research Citalopram Confidence intervals Feasibility Studies Female Humans Image Interpretation, Computer-Assisted Magnetic Resonance Imaging - methods Medical imaging Pharmacological MRI Repeatability Reproducibility of Results Serotonin - analysis Serotonin - metabolism Serotonin Uptake Inhibitors Single-Blind Method Spin Labels SSRIs Studies Young Adult |
| title | Feasibility of ASL-based phMRI with a single dose of oral citalopram for repeated assessment of serotonin function |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T20%3A45%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Feasibility%20of%20ASL-based%20phMRI%20with%20a%20single%20dose%20of%20oral%20citalopram%20for%20repeated%20assessment%20of%20serotonin%20function&rft.jtitle=NeuroImage%20(Orlando,%20Fla.)&rft.au=Klomp,%20A.&rft.date=2012-11-15&rft.volume=63&rft.issue=3&rft.spage=1695&rft.epage=1700&rft.pages=1695-1700&rft.issn=1053-8119&rft.eissn=1095-9572&rft_id=info:doi/10.1016/j.neuroimage.2012.07.038&rft_dat=%3Cproquest_cross%3E3245072971%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1506886751&rft_id=info:pmid/22842212&rft_els_id=S1053811912007677&rfr_iscdi=true |