History of cigarette smoking is associated with higher limbic GABAA receptor availability

Cigarette smoking presents a significant worldwide healthcare challenge. Preclinical, genetic association and clinical trials studies provide considerable evidence for the involvement of the human γ-aminobutyric acid (GABA) system in the neurobiology of nicotine addiction. However there are few huma...

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Veröffentlicht in:	NeuroImage (Orlando, Fla.) Fla.), 2013-04, Vol.69, p.70-77
Hauptverfasser:	Stokes, Paul R.A., Benecke, Aaf, Myers, Jim, Erritzoe, David, Watson, Ben J., Kalk, Nicola, Barros, Daniela Riano, Hammers, Alexander, Nutt, David J., Lingford-Hughes, Anne R.
Format:	Artikel
Sprache:	eng
Schlagworte:	[11C]Ro15 4513 Addiction Biological and medical sciences Fundamental and applied biological sciences. Psychology GABA Humans Image Interpretation, Computer-Assisted Limbic Limbic System - diagnostic imaging Limbic System - metabolism Male Middle Aged Nicotine PET Positron-Emission Tomography Receptors, GABA-A - metabolism Smoking - metabolism Vertebrates: nervous system and sense organs
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