BMP-Smad 1/5/8 signalling in the development of the nervous system
The transcription factors, Smad1, Smad5 and Smad8, are the pivotal intracellular effectors of the bone morphogenetic protein (BMP) family of proteins. BMPs and their receptors are expressed in the nervous system (NS) throughout its development. This review focuses on the actions of Smad 1/5/8 in the...
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| Veröffentlicht in: | Progress in neurobiology 2013-10, Vol.109, p.28-41 |
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| creator | Hegarty, Shane V O'Keeffe, Gerard W Sullivan, Aideen M |
| description | The transcription factors, Smad1, Smad5 and Smad8, are the pivotal intracellular effectors of the bone morphogenetic protein (BMP) family of proteins. BMPs and their receptors are expressed in the nervous system (NS) throughout its development. This review focuses on the actions of Smad 1/5/8 in the developing NS. The mechanisms by which these Smad proteins regulate the induction of the neuroectoderm, the central nervous system (CNS) primordium, and finally the neural crest, which gives rise to the peripheral nervous system (PNS), are reviewed herein. We describe how, following neural tube closure, the most dorsal aspect of the tube becomes a signalling centre for BMPs, which directs the pattern of the development of the dorsal spinal cord (SC), through the action of Smad1, Smad5 and Smad8. The direct effects of Smad 1/5/8 signalling on the development of neuronal and non-neuronal cells from various neural progenitor cell populations are then described. Finally, this review discusses the neurodevelopmental abnormalities associated with the knockdown of Smad 1/5/8. |
| doi_str_mv | 10.1016/j.pneurobio.2013.07.002 |
| format | Article |
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BMPs and their receptors are expressed in the nervous system (NS) throughout its development. This review focuses on the actions of Smad 1/5/8 in the developing NS. The mechanisms by which these Smad proteins regulate the induction of the neuroectoderm, the central nervous system (CNS) primordium, and finally the neural crest, which gives rise to the peripheral nervous system (PNS), are reviewed herein. We describe how, following neural tube closure, the most dorsal aspect of the tube becomes a signalling centre for BMPs, which directs the pattern of the development of the dorsal spinal cord (SC), through the action of Smad1, Smad5 and Smad8. The direct effects of Smad 1/5/8 signalling on the development of neuronal and non-neuronal cells from various neural progenitor cell populations are then described. Finally, this review discusses the neurodevelopmental abnormalities associated with the knockdown of Smad 1/5/8.</description><identifier>ISSN: 0301-0082</identifier><identifier>EISSN: 1873-5118</identifier><identifier>DOI: 10.1016/j.pneurobio.2013.07.002</identifier><identifier>PMID: 23891815</identifier><language>eng</language><publisher>England</publisher><subject>Animals ; Bone Morphogenetic Proteins - biosynthesis ; Bone Morphogenetic Proteins - genetics ; Humans ; Nervous System - growth & development ; Nervous System - metabolism ; Nervous System Diseases - genetics ; Nervous System Diseases - metabolism ; Signal Transduction - physiology ; Smad1 Protein - biosynthesis ; Smad1 Protein - genetics ; Smad5 Protein - biosynthesis ; Smad5 Protein - genetics ; Smad8 Protein - biosynthesis ; Smad8 Protein - genetics</subject><ispartof>Progress in neurobiology, 2013-10, Vol.109, p.28-41</ispartof><rights>Copyright © 2013 Elsevier Ltd. 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| ispartof | Progress in neurobiology, 2013-10, Vol.109, p.28-41 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Bone Morphogenetic Proteins - biosynthesis Bone Morphogenetic Proteins - genetics Humans Nervous System - growth & development Nervous System - metabolism Nervous System Diseases - genetics Nervous System Diseases - metabolism Signal Transduction - physiology Smad1 Protein - biosynthesis Smad1 Protein - genetics Smad5 Protein - biosynthesis Smad5 Protein - genetics Smad8 Protein - biosynthesis Smad8 Protein - genetics |
| title | BMP-Smad 1/5/8 signalling in the development of the nervous system |
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