Distribution and ecological impact of artemisinin derived from Artemisia annua L. in an agricultural ecosystem
The sesquiterpene lactone artemisinin is currently the most promising agent in reducing dispersion of the malaria parasite in infected patients. Artemisinin is a secondary metabolite produced by Artemisia annua L. The plant is cultivated worldwide at large scale to meet the global demand. Artemisini...
Gespeichert in:
| Veröffentlicht in: | Soil biology & biochemistry 2013-02, Vol.57, p.164-172 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 172 |
|---|---|
| container_issue | |
| container_start_page | 164 |
| container_title | Soil biology & biochemistry |
| container_volume | 57 |
| creator | Herrmann, Sarah Jessing, Karina K. Jørgensen, Niels O.G. Cedergreen, Nina Kandeler, Ellen Strobel, Bjarne W. |
| description | The sesquiterpene lactone artemisinin is currently the most promising agent in reducing dispersion of the malaria parasite in infected patients. Artemisinin is a secondary metabolite produced by Artemisia annua L. The plant is cultivated worldwide at large scale to meet the global demand. Artemisinin is known to pose herbicidal and antimicrobial effects, implying environmental risks. In this study, content of artemisinin in plants was related to the concentrations and distribution in the soil during a growth season. The long term effect of artemisinin on activity of the soil bacteria was studied from analysis of the protein synthesis (incorporation rate of leucine) in slurries from plots with and without A. annua. Further, short-term effects of artemisinin were examined by counting bacterial colony forming units from suspensions of these two soils growing on artemisinin-spiked and non-spiked agar.
The concentration of artemisinin in the upper 10 cm soil varied from below the limit of detection (10.6 μg kg−1 soil) to 440 μg kg−1 soil and was highest at the stage of flowering. The distribution of artemisinin was diffuse and artemisinin was detected up to 15 m from the plants, indicating that wind was a key factor in horizontal dispersal of artemisinin. Adsorption potential of artemisinin to soil particles was found to decline with depth. Artemisinin leached from topsoil to subsoil layers measured after an intense rain event, giving maximum concentrations at 70–90 cm depths and no detectable artemisinin in the topsoil. Cultivation on agar media showed that addition of artemisinin had a negative impact on growth of soil bacteria that had not previously being exposed to artemisinin, while bacteria from the A. annua soils were unaffected by the artemisinin spiking. Cultivation of A. annua also appeared to impact the proportion of culturable bacteria and composition of the bacterial populations. Our study demonstrates that artemisinin is a mobile compound in soil environments and that the cultivation of A. annua impacts bacterial activity and composition in soils in situ.
► Dispersal of artemisinin from Artemisia annua L. cultivation was studied in soil. ► The distribution of artemisinin in soil was diffuse and was influenced by wind. ► Artemisinin leached to subsurface layers despite strong adsorption to the topsoil. ► Cultivation of A. annua impacted the microbial activity and composition. |
| doi_str_mv | 10.1016/j.soilbio.2012.08.011 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1500767903</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0038071712003136</els_id><sourcerecordid>1500767903</sourcerecordid><originalsourceid>FETCH-LOGICAL-c396t-e021e45467a02955e21ebd74f91c0e219d81024e98d4c23791936b7ad2a9def33</originalsourceid><addsrcrecordid>eNqFkE1r3DAQhkVJIZs0PyFUl0Ivdkfyh6xTCeknLPSQ5Cy00jjM4pW2kh3Iv4_MLr32JAY98-rVw9itgFqA6L_s6xxp2lGsJQhZw1CDEO_YRgxKV00rhwu2AWiGCpRQl-wq5z0AyE40Gxa-UZ4T7ZaZYuA2eI4uTvGZnJ04HY7WzTyO3KYZD5QpUOAeE72g52OKB353vrBlNyyWb2tOaw63z4ncMs1LKkElM7_mQn5g70c7Zbw5n9fs6cf3x_tf1fbPz9_3d9vKNbqfKwQpsO3aXlmQuuuwjDuv2lELB2XQfhAgW9SDb51slBa66XfKemm1x7FprtnnU-4xxb8L5tmUkg6nyQaMSzaiA1C90rCi3Ql1KeaccDTHRAebXo0As_o1e3P2a1a_BgZT_Ja9T-cnbC6yxmSDo_xvWSohe2j7wn08caONZrWSzdNDCSoNSofyj0J8PRFYjLwQJpMdYXDoKaGbjY_0ny5v6DidjQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1500767903</pqid></control><display><type>article</type><title>Distribution and ecological impact of artemisinin derived from Artemisia annua L. in an agricultural ecosystem</title><source>Elsevier ScienceDirect Journals Complete</source><creator>Herrmann, Sarah ; Jessing, Karina K. ; Jørgensen, Niels O.G. ; Cedergreen, Nina ; Kandeler, Ellen ; Strobel, Bjarne W.</creator><creatorcontrib>Herrmann, Sarah ; Jessing, Karina K. ; Jørgensen, Niels O.G. ; Cedergreen, Nina ; Kandeler, Ellen ; Strobel, Bjarne W.</creatorcontrib><description>The sesquiterpene lactone artemisinin is currently the most promising agent in reducing dispersion of the malaria parasite in infected patients. Artemisinin is a secondary metabolite produced by Artemisia annua L. The plant is cultivated worldwide at large scale to meet the global demand. Artemisinin is known to pose herbicidal and antimicrobial effects, implying environmental risks. In this study, content of artemisinin in plants was related to the concentrations and distribution in the soil during a growth season. The long term effect of artemisinin on activity of the soil bacteria was studied from analysis of the protein synthesis (incorporation rate of leucine) in slurries from plots with and without A. annua. Further, short-term effects of artemisinin were examined by counting bacterial colony forming units from suspensions of these two soils growing on artemisinin-spiked and non-spiked agar.
The concentration of artemisinin in the upper 10 cm soil varied from below the limit of detection (10.6 μg kg−1 soil) to 440 μg kg−1 soil and was highest at the stage of flowering. The distribution of artemisinin was diffuse and artemisinin was detected up to 15 m from the plants, indicating that wind was a key factor in horizontal dispersal of artemisinin. Adsorption potential of artemisinin to soil particles was found to decline with depth. Artemisinin leached from topsoil to subsoil layers measured after an intense rain event, giving maximum concentrations at 70–90 cm depths and no detectable artemisinin in the topsoil. Cultivation on agar media showed that addition of artemisinin had a negative impact on growth of soil bacteria that had not previously being exposed to artemisinin, while bacteria from the A. annua soils were unaffected by the artemisinin spiking. Cultivation of A. annua also appeared to impact the proportion of culturable bacteria and composition of the bacterial populations. Our study demonstrates that artemisinin is a mobile compound in soil environments and that the cultivation of A. annua impacts bacterial activity and composition in soils in situ.
► Dispersal of artemisinin from Artemisia annua L. cultivation was studied in soil. ► The distribution of artemisinin in soil was diffuse and was influenced by wind. ► Artemisinin leached to subsurface layers despite strong adsorption to the topsoil. ► Cultivation of A. annua impacted the microbial activity and composition.</description><identifier>ISSN: 0038-0717</identifier><identifier>EISSN: 1879-3428</identifier><identifier>DOI: 10.1016/j.soilbio.2012.08.011</identifier><identifier>CODEN: SBIOAH</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Active pharmaceutical ingredient ; adsorption ; agar ; Agronomy. Soil science and plant productions ; antimicrobial properties ; Artemisia annua ; artemisinin ; Bioactive ; Biochemistry and biology ; Biological and medical sciences ; Chemical, physicochemical, biochemical and biological properties ; detection limit ; ecosystems ; Emerging contaminant ; environmental impact ; flowering ; Fundamental and applied biological sciences. Psychology ; leucine ; long term effects ; malaria ; metabolites ; parasites ; patients ; Physics, chemistry, biochemistry and biology of agricultural and forest soils ; protein synthesis ; Qinghaosu ; rain ; risk ; slurries ; soil bacteria ; Soil science ; subsoiling ; topsoil ; wind</subject><ispartof>Soil biology & biochemistry, 2013-02, Vol.57, p.164-172</ispartof><rights>2012 Elsevier Ltd</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-e021e45467a02955e21ebd74f91c0e219d81024e98d4c23791936b7ad2a9def33</citedby><cites>FETCH-LOGICAL-c396t-e021e45467a02955e21ebd74f91c0e219d81024e98d4c23791936b7ad2a9def33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.soilbio.2012.08.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27126046$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Herrmann, Sarah</creatorcontrib><creatorcontrib>Jessing, Karina K.</creatorcontrib><creatorcontrib>Jørgensen, Niels O.G.</creatorcontrib><creatorcontrib>Cedergreen, Nina</creatorcontrib><creatorcontrib>Kandeler, Ellen</creatorcontrib><creatorcontrib>Strobel, Bjarne W.</creatorcontrib><title>Distribution and ecological impact of artemisinin derived from Artemisia annua L. in an agricultural ecosystem</title><title>Soil biology & biochemistry</title><description>The sesquiterpene lactone artemisinin is currently the most promising agent in reducing dispersion of the malaria parasite in infected patients. Artemisinin is a secondary metabolite produced by Artemisia annua L. The plant is cultivated worldwide at large scale to meet the global demand. Artemisinin is known to pose herbicidal and antimicrobial effects, implying environmental risks. In this study, content of artemisinin in plants was related to the concentrations and distribution in the soil during a growth season. The long term effect of artemisinin on activity of the soil bacteria was studied from analysis of the protein synthesis (incorporation rate of leucine) in slurries from plots with and without A. annua. Further, short-term effects of artemisinin were examined by counting bacterial colony forming units from suspensions of these two soils growing on artemisinin-spiked and non-spiked agar.
The concentration of artemisinin in the upper 10 cm soil varied from below the limit of detection (10.6 μg kg−1 soil) to 440 μg kg−1 soil and was highest at the stage of flowering. The distribution of artemisinin was diffuse and artemisinin was detected up to 15 m from the plants, indicating that wind was a key factor in horizontal dispersal of artemisinin. Adsorption potential of artemisinin to soil particles was found to decline with depth. Artemisinin leached from topsoil to subsoil layers measured after an intense rain event, giving maximum concentrations at 70–90 cm depths and no detectable artemisinin in the topsoil. Cultivation on agar media showed that addition of artemisinin had a negative impact on growth of soil bacteria that had not previously being exposed to artemisinin, while bacteria from the A. annua soils were unaffected by the artemisinin spiking. Cultivation of A. annua also appeared to impact the proportion of culturable bacteria and composition of the bacterial populations. Our study demonstrates that artemisinin is a mobile compound in soil environments and that the cultivation of A. annua impacts bacterial activity and composition in soils in situ.
► Dispersal of artemisinin from Artemisia annua L. cultivation was studied in soil. ► The distribution of artemisinin in soil was diffuse and was influenced by wind. ► Artemisinin leached to subsurface layers despite strong adsorption to the topsoil. ► Cultivation of A. annua impacted the microbial activity and composition.</description><subject>Active pharmaceutical ingredient</subject><subject>adsorption</subject><subject>agar</subject><subject>Agronomy. Soil science and plant productions</subject><subject>antimicrobial properties</subject><subject>Artemisia annua</subject><subject>artemisinin</subject><subject>Bioactive</subject><subject>Biochemistry and biology</subject><subject>Biological and medical sciences</subject><subject>Chemical, physicochemical, biochemical and biological properties</subject><subject>detection limit</subject><subject>ecosystems</subject><subject>Emerging contaminant</subject><subject>environmental impact</subject><subject>flowering</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>leucine</subject><subject>long term effects</subject><subject>malaria</subject><subject>metabolites</subject><subject>parasites</subject><subject>patients</subject><subject>Physics, chemistry, biochemistry and biology of agricultural and forest soils</subject><subject>protein synthesis</subject><subject>Qinghaosu</subject><subject>rain</subject><subject>risk</subject><subject>slurries</subject><subject>soil bacteria</subject><subject>Soil science</subject><subject>subsoiling</subject><subject>topsoil</subject><subject>wind</subject><issn>0038-0717</issn><issn>1879-3428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqFkE1r3DAQhkVJIZs0PyFUl0Ivdkfyh6xTCeknLPSQ5Cy00jjM4pW2kh3Iv4_MLr32JAY98-rVw9itgFqA6L_s6xxp2lGsJQhZw1CDEO_YRgxKV00rhwu2AWiGCpRQl-wq5z0AyE40Gxa-UZ4T7ZaZYuA2eI4uTvGZnJ04HY7WzTyO3KYZD5QpUOAeE72g52OKB353vrBlNyyWb2tOaw63z4ncMs1LKkElM7_mQn5g70c7Zbw5n9fs6cf3x_tf1fbPz9_3d9vKNbqfKwQpsO3aXlmQuuuwjDuv2lELB2XQfhAgW9SDb51slBa66XfKemm1x7FprtnnU-4xxb8L5tmUkg6nyQaMSzaiA1C90rCi3Ql1KeaccDTHRAebXo0As_o1e3P2a1a_BgZT_Ja9T-cnbC6yxmSDo_xvWSohe2j7wn08caONZrWSzdNDCSoNSofyj0J8PRFYjLwQJpMdYXDoKaGbjY_0ny5v6DidjQ</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Herrmann, Sarah</creator><creator>Jessing, Karina K.</creator><creator>Jørgensen, Niels O.G.</creator><creator>Cedergreen, Nina</creator><creator>Kandeler, Ellen</creator><creator>Strobel, Bjarne W.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SN</scope><scope>7UA</scope><scope>C1K</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope></search><sort><creationdate>20130201</creationdate><title>Distribution and ecological impact of artemisinin derived from Artemisia annua L. in an agricultural ecosystem</title><author>Herrmann, Sarah ; Jessing, Karina K. ; Jørgensen, Niels O.G. ; Cedergreen, Nina ; Kandeler, Ellen ; Strobel, Bjarne W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-e021e45467a02955e21ebd74f91c0e219d81024e98d4c23791936b7ad2a9def33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Active pharmaceutical ingredient</topic><topic>adsorption</topic><topic>agar</topic><topic>Agronomy. Soil science and plant productions</topic><topic>antimicrobial properties</topic><topic>Artemisia annua</topic><topic>artemisinin</topic><topic>Bioactive</topic><topic>Biochemistry and biology</topic><topic>Biological and medical sciences</topic><topic>Chemical, physicochemical, biochemical and biological properties</topic><topic>detection limit</topic><topic>ecosystems</topic><topic>Emerging contaminant</topic><topic>environmental impact</topic><topic>flowering</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>leucine</topic><topic>long term effects</topic><topic>malaria</topic><topic>metabolites</topic><topic>parasites</topic><topic>patients</topic><topic>Physics, chemistry, biochemistry and biology of agricultural and forest soils</topic><topic>protein synthesis</topic><topic>Qinghaosu</topic><topic>rain</topic><topic>risk</topic><topic>slurries</topic><topic>soil bacteria</topic><topic>Soil science</topic><topic>subsoiling</topic><topic>topsoil</topic><topic>wind</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Herrmann, Sarah</creatorcontrib><creatorcontrib>Jessing, Karina K.</creatorcontrib><creatorcontrib>Jørgensen, Niels O.G.</creatorcontrib><creatorcontrib>Cedergreen, Nina</creatorcontrib><creatorcontrib>Kandeler, Ellen</creatorcontrib><creatorcontrib>Strobel, Bjarne W.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Ecology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>Soil biology & biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Herrmann, Sarah</au><au>Jessing, Karina K.</au><au>Jørgensen, Niels O.G.</au><au>Cedergreen, Nina</au><au>Kandeler, Ellen</au><au>Strobel, Bjarne W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution and ecological impact of artemisinin derived from Artemisia annua L. in an agricultural ecosystem</atitle><jtitle>Soil biology & biochemistry</jtitle><date>2013-02-01</date><risdate>2013</risdate><volume>57</volume><spage>164</spage><epage>172</epage><pages>164-172</pages><issn>0038-0717</issn><eissn>1879-3428</eissn><coden>SBIOAH</coden><abstract>The sesquiterpene lactone artemisinin is currently the most promising agent in reducing dispersion of the malaria parasite in infected patients. Artemisinin is a secondary metabolite produced by Artemisia annua L. The plant is cultivated worldwide at large scale to meet the global demand. Artemisinin is known to pose herbicidal and antimicrobial effects, implying environmental risks. In this study, content of artemisinin in plants was related to the concentrations and distribution in the soil during a growth season. The long term effect of artemisinin on activity of the soil bacteria was studied from analysis of the protein synthesis (incorporation rate of leucine) in slurries from plots with and without A. annua. Further, short-term effects of artemisinin were examined by counting bacterial colony forming units from suspensions of these two soils growing on artemisinin-spiked and non-spiked agar.
The concentration of artemisinin in the upper 10 cm soil varied from below the limit of detection (10.6 μg kg−1 soil) to 440 μg kg−1 soil and was highest at the stage of flowering. The distribution of artemisinin was diffuse and artemisinin was detected up to 15 m from the plants, indicating that wind was a key factor in horizontal dispersal of artemisinin. Adsorption potential of artemisinin to soil particles was found to decline with depth. Artemisinin leached from topsoil to subsoil layers measured after an intense rain event, giving maximum concentrations at 70–90 cm depths and no detectable artemisinin in the topsoil. Cultivation on agar media showed that addition of artemisinin had a negative impact on growth of soil bacteria that had not previously being exposed to artemisinin, while bacteria from the A. annua soils were unaffected by the artemisinin spiking. Cultivation of A. annua also appeared to impact the proportion of culturable bacteria and composition of the bacterial populations. Our study demonstrates that artemisinin is a mobile compound in soil environments and that the cultivation of A. annua impacts bacterial activity and composition in soils in situ.
► Dispersal of artemisinin from Artemisia annua L. cultivation was studied in soil. ► The distribution of artemisinin in soil was diffuse and was influenced by wind. ► Artemisinin leached to subsurface layers despite strong adsorption to the topsoil. ► Cultivation of A. annua impacted the microbial activity and composition.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><doi>10.1016/j.soilbio.2012.08.011</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0038-0717 |
| ispartof | Soil biology & biochemistry, 2013-02, Vol.57, p.164-172 |
| issn | 0038-0717 1879-3428 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1500767903 |
| source | Elsevier ScienceDirect Journals Complete |
| subjects | Active pharmaceutical ingredient adsorption agar Agronomy. Soil science and plant productions antimicrobial properties Artemisia annua artemisinin Bioactive Biochemistry and biology Biological and medical sciences Chemical, physicochemical, biochemical and biological properties detection limit ecosystems Emerging contaminant environmental impact flowering Fundamental and applied biological sciences. Psychology leucine long term effects malaria metabolites parasites patients Physics, chemistry, biochemistry and biology of agricultural and forest soils protein synthesis Qinghaosu rain risk slurries soil bacteria Soil science subsoiling topsoil wind |
| title | Distribution and ecological impact of artemisinin derived from Artemisia annua L. in an agricultural ecosystem |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T06%3A32%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Distribution%20and%20ecological%20impact%20of%20artemisinin%20derived%20from%20Artemisia%20annua%20L.%20in%20an%20agricultural%20ecosystem&rft.jtitle=Soil%20biology%20&%20biochemistry&rft.au=Herrmann,%20Sarah&rft.date=2013-02-01&rft.volume=57&rft.spage=164&rft.epage=172&rft.pages=164-172&rft.issn=0038-0717&rft.eissn=1879-3428&rft.coden=SBIOAH&rft_id=info:doi/10.1016/j.soilbio.2012.08.011&rft_dat=%3Cproquest_cross%3E1500767903%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1500767903&rft_id=info:pmid/&rft_els_id=S0038071712003136&rfr_iscdi=true |