Evaluation of Brucella abortus S19 vaccines commercialized in Brazil: Immunogenicity, residual virulence and MLVA15 genotyping

Highlights • Batches of S19 Brucella abortus vaccine from all commercial vaccines used in Brazil were tested for potency, residual virulence and MLVA15. • Potency and residual virulence results from all batches attained national and international recommendations. • MLVA15 from all batches, except tw...

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Veröffentlicht in:	Vaccine 2013-06, Vol.31 (29), p.3014-3018
Hauptverfasser:	Miranda, Karina Leite, Poester, Fernando Padilla, Minharro, Silvia, Dorneles, Elaine Maria Seles, Stynen, Ana Paula Reinato, Lage, Andrey Pereira
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Applied microbiology Bacterial diseases bacterial vaccines Bacteriology Biological and medical sciences Brazil - epidemiology Brucella abortus Brucella abortus - genetics Brucella abortus - immunology Brucella abortus - pathogenicity Brucella melitensis biovar Abortus Brucella Vaccine - adverse effects Brucella Vaccine - genetics Brucella Vaccine - immunology Brucellosis Brucellosis - epidemiology Brucellosis - prevention & control Brucellosis - veterinary Cattle Female Fundamental and applied biological sciences. Psychology genetic stability Genomic Instability Genotyping Human bacterial diseases immune response Infectious diseases loci Medical sciences Mice Microbiology minisatellite repeats Minisatellite Repeats - genetics Minisatellite Repeats - immunology Miscellaneous quality control USDA Vaccine control Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Attenuated - adverse effects Vaccines, Attenuated - genetics Vaccines, Attenuated - immunology virulence
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Zusammenfassung:	Highlights • Batches of S19 Brucella abortus vaccine from all commercial vaccines used in Brazil were tested for potency, residual virulence and MLVA15. • Potency and residual virulence results from all batches attained national and international recommendations. • MLVA15 from all batches, except two batches from one producer, showed genotypes identical to the USDA S19 reference strain. • Although presenting a slightly different profile from the other S19 preparations, two batches also showed similar protection.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.04.054