Behavioral and neurochemical characterization of maternal care effects on juvenile Sprague–Dawley rats
Abstract Maternal care represents a major constituent of early life environment and has the potential to modulate critical neurobehavioral responses to stress. The aim of the present study was to determine the effects of naturally occurring variations in maternal care on behavioral and neurochemical...
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| Veröffentlicht in: | Physiology & behavior 2013-06, Vol.118, p.212-217 |
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| creator | Masís-Calvo, Marianela Sequeira-Cordero, Andrey Mora-Gallegos, Andrea Fornaguera-Trías, Jaime |
| description | Abstract Maternal care represents a major constituent of early life environment and has the potential to modulate critical neurobehavioral responses to stress. The aim of the present study was to determine the effects of naturally occurring variations in maternal care on behavioral and neurochemical responses of juvenile Sprague–Dawley rats. A group of dams were classified based on their licking behavior in high and low licking-grooming mothers. Afterwards, the male offspring was tested in a series of behavioral tests: open field test (OFT), elevated plus maze (EPM) and forced swimming test (FST). Additionally, monoamine concentrations were determined post-mortem in three brain regions: hippocampus, ventral striatum and prefrontal cortex. Our findings suggest that maternal care variations have an effect on several anxiety-related behaviors in OFT and EPM but not in depression-like behaviors in FST. Such behavioral differences could be related to an increased DOPAC concentration and 5-HT turnover in prefrontal cortex. These evidences suggest that natural variations in maternal care modified some behavioral and neurochemical parameters related with anxiety and stress in this strain. |
| doi_str_mv | 10.1016/j.physbeh.2013.05.033 |
| format | Article |
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The aim of the present study was to determine the effects of naturally occurring variations in maternal care on behavioral and neurochemical responses of juvenile Sprague–Dawley rats. A group of dams were classified based on their licking behavior in high and low licking-grooming mothers. Afterwards, the male offspring was tested in a series of behavioral tests: open field test (OFT), elevated plus maze (EPM) and forced swimming test (FST). Additionally, monoamine concentrations were determined post-mortem in three brain regions: hippocampus, ventral striatum and prefrontal cortex. Our findings suggest that maternal care variations have an effect on several anxiety-related behaviors in OFT and EPM but not in depression-like behaviors in FST. Such behavioral differences could be related to an increased DOPAC concentration and 5-HT turnover in prefrontal cortex. These evidences suggest that natural variations in maternal care modified some behavioral and neurochemical parameters related with anxiety and stress in this strain.</description><identifier>ISSN: 0031-9384</identifier><identifier>EISSN: 1873-507X</identifier><identifier>DOI: 10.1016/j.physbeh.2013.05.033</identifier><identifier>PMID: 23711565</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Animals ; Anxiety ; Anxiety - physiopathology ; Anxiety - psychology ; Behavior, Animal - physiology ; Behavioral psychophysiology ; Biogenic Monoamines - metabolism ; Biological and medical sciences ; Brain Chemistry - physiology ; Chromatography, High Pressure Liquid ; cortex ; Data Interpretation, Statistical ; Dopamine - metabolism ; Electrochemistry ; Electrodes, Implanted ; Female ; Fundamental and applied biological sciences. Psychology ; Grooming ; Grooming behavior ; hippocampus ; Hippocampus - metabolism ; Hydroxyindoleacetic Acid - metabolism ; Maternal Behavior - physiology ; Maternal care ; Monoamines ; mothers ; Motor Activity - physiology ; Neostriatum - metabolism ; Neurotransmitter Agents - metabolism ; Prefrontal Cortex - metabolism ; progeny ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Sprague-Dawley ; Restraint, Physical - physiology ; Restraint, Physical - psychology ; serotonin ; Serotonin - metabolism ; Sprague–Dawley ; Stress response ; Stress, Psychological - physiopathology ; Stress, Psychological - psychology ; swimming ; Swimming - psychology</subject><ispartof>Physiology & behavior, 2013-06, Vol.118, p.212-217</ispartof><rights>Elsevier Inc.</rights><rights>2013 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c573t-5926aa1c2442ae3e92111195840f2803112784a11dcb4570af407bb66b4cbd303</citedby><cites>FETCH-LOGICAL-c573t-5926aa1c2442ae3e92111195840f2803112784a11dcb4570af407bb66b4cbd303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.physbeh.2013.05.033$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27619182$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23711565$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Masís-Calvo, Marianela</creatorcontrib><creatorcontrib>Sequeira-Cordero, Andrey</creatorcontrib><creatorcontrib>Mora-Gallegos, Andrea</creatorcontrib><creatorcontrib>Fornaguera-Trías, Jaime</creatorcontrib><title>Behavioral and neurochemical characterization of maternal care effects on juvenile Sprague–Dawley rats</title><title>Physiology & behavior</title><addtitle>Physiol Behav</addtitle><description>Abstract Maternal care represents a major constituent of early life environment and has the potential to modulate critical neurobehavioral responses to stress. The aim of the present study was to determine the effects of naturally occurring variations in maternal care on behavioral and neurochemical responses of juvenile Sprague–Dawley rats. A group of dams were classified based on their licking behavior in high and low licking-grooming mothers. Afterwards, the male offspring was tested in a series of behavioral tests: open field test (OFT), elevated plus maze (EPM) and forced swimming test (FST). Additionally, monoamine concentrations were determined post-mortem in three brain regions: hippocampus, ventral striatum and prefrontal cortex. Our findings suggest that maternal care variations have an effect on several anxiety-related behaviors in OFT and EPM but not in depression-like behaviors in FST. Such behavioral differences could be related to an increased DOPAC concentration and 5-HT turnover in prefrontal cortex. These evidences suggest that natural variations in maternal care modified some behavioral and neurochemical parameters related with anxiety and stress in this strain.</description><subject>Animals</subject><subject>Anxiety</subject><subject>Anxiety - physiopathology</subject><subject>Anxiety - psychology</subject><subject>Behavior, Animal - physiology</subject><subject>Behavioral psychophysiology</subject><subject>Biogenic Monoamines - metabolism</subject><subject>Biological and medical sciences</subject><subject>Brain Chemistry - physiology</subject><subject>Chromatography, High Pressure Liquid</subject><subject>cortex</subject><subject>Data Interpretation, Statistical</subject><subject>Dopamine - metabolism</subject><subject>Electrochemistry</subject><subject>Electrodes, Implanted</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Grooming</subject><subject>Grooming behavior</subject><subject>hippocampus</subject><subject>Hippocampus - metabolism</subject><subject>Hydroxyindoleacetic Acid - metabolism</subject><subject>Maternal Behavior - physiology</subject><subject>Maternal care</subject><subject>Monoamines</subject><subject>mothers</subject><subject>Motor Activity - physiology</subject><subject>Neostriatum - metabolism</subject><subject>Neurotransmitter Agents - metabolism</subject><subject>Prefrontal Cortex - metabolism</subject><subject>progeny</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Restraint, Physical - physiology</subject><subject>Restraint, Physical - psychology</subject><subject>serotonin</subject><subject>Serotonin - metabolism</subject><subject>Sprague–Dawley</subject><subject>Stress response</subject><subject>Stress, Psychological - physiopathology</subject><subject>Stress, Psychological - psychology</subject><subject>swimming</subject><subject>Swimming - psychology</subject><issn>0031-9384</issn><issn>1873-507X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksmO1DAQhiMEYpqBRwByQeLSjctLnFxAMKzSSByakbhZFacyccjS2Emj5sQ78IY8CY66AYnL-GLZ9dX6V5I8BLYBBtmzdrNrDqGkZsMZiA1TGybErWQFuRZrxfTn28mKMQHrQuTyLLkXQsviEVLcTc640AAqU6ukeUUN7t3osUtxqNKBZj_ahnpn449t0KOdyLvvOLlxSMc67TG-h8WInlKqa7JTSKOtnfc0uI7S7c7j9Uy_fvx8jd86OqQep3A_uVNjF-jB6T5Prt6--XTxfn358d2Hi5eXa6u0mNaq4BkiWC4lRxJUcIinULlkNc9jP8B1LhGgsqVUmmEtmS7LLCulLSvBxHny9Bh358evM4XJ9C5Y6jocaJyDAcWYzjKp-M2oBMgEl8WCqiNq_RiCp9rsvOvRHwwws-hhWnPSwyx6GKZM1CP6PTqlmMueqr9efwSIwJMTgCFOvPY4WBf-cTqDAvKlgMdHrsbR4LWPzNU2ZordgM6k0JF4cSQoTnfvyJtgHQ2WKuejRKYa3Y3FPv8vgu3csCzCFzpQaMd50T3OxQRumNku67VsF4ilCCXEbzBPyiA</recordid><startdate>20130613</startdate><enddate>20130613</enddate><creator>Masís-Calvo, Marianela</creator><creator>Sequeira-Cordero, Andrey</creator><creator>Mora-Gallegos, Andrea</creator><creator>Fornaguera-Trías, Jaime</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QG</scope><scope>7TK</scope></search><sort><creationdate>20130613</creationdate><title>Behavioral and neurochemical characterization of maternal care effects on juvenile Sprague–Dawley rats</title><author>Masís-Calvo, Marianela ; Sequeira-Cordero, Andrey ; Mora-Gallegos, Andrea ; Fornaguera-Trías, Jaime</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c573t-5926aa1c2442ae3e92111195840f2803112784a11dcb4570af407bb66b4cbd303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Anxiety</topic><topic>Anxiety - physiopathology</topic><topic>Anxiety - psychology</topic><topic>Behavior, Animal - physiology</topic><topic>Behavioral psychophysiology</topic><topic>Biogenic Monoamines - metabolism</topic><topic>Biological and medical sciences</topic><topic>Brain Chemistry - physiology</topic><topic>Chromatography, High Pressure Liquid</topic><topic>cortex</topic><topic>Data Interpretation, Statistical</topic><topic>Dopamine - metabolism</topic><topic>Electrochemistry</topic><topic>Electrodes, Implanted</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Grooming</topic><topic>Grooming behavior</topic><topic>hippocampus</topic><topic>Hippocampus - metabolism</topic><topic>Hydroxyindoleacetic Acid - metabolism</topic><topic>Maternal Behavior - physiology</topic><topic>Maternal care</topic><topic>Monoamines</topic><topic>mothers</topic><topic>Motor Activity - physiology</topic><topic>Neostriatum - metabolism</topic><topic>Neurotransmitter Agents - metabolism</topic><topic>Prefrontal Cortex - metabolism</topic><topic>progeny</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Restraint, Physical - physiology</topic><topic>Restraint, Physical - psychology</topic><topic>serotonin</topic><topic>Serotonin - metabolism</topic><topic>Sprague–Dawley</topic><topic>Stress response</topic><topic>Stress, Psychological - physiopathology</topic><topic>Stress, Psychological - psychology</topic><topic>swimming</topic><topic>Swimming - psychology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Masís-Calvo, Marianela</creatorcontrib><creatorcontrib>Sequeira-Cordero, Andrey</creatorcontrib><creatorcontrib>Mora-Gallegos, Andrea</creatorcontrib><creatorcontrib>Fornaguera-Trías, Jaime</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><jtitle>Physiology & behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Masís-Calvo, Marianela</au><au>Sequeira-Cordero, Andrey</au><au>Mora-Gallegos, Andrea</au><au>Fornaguera-Trías, Jaime</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Behavioral and neurochemical characterization of maternal care effects on juvenile Sprague–Dawley rats</atitle><jtitle>Physiology & behavior</jtitle><addtitle>Physiol Behav</addtitle><date>2013-06-13</date><risdate>2013</risdate><volume>118</volume><spage>212</spage><epage>217</epage><pages>212-217</pages><issn>0031-9384</issn><eissn>1873-507X</eissn><abstract>Abstract Maternal care represents a major constituent of early life environment and has the potential to modulate critical neurobehavioral responses to stress. The aim of the present study was to determine the effects of naturally occurring variations in maternal care on behavioral and neurochemical responses of juvenile Sprague–Dawley rats. A group of dams were classified based on their licking behavior in high and low licking-grooming mothers. Afterwards, the male offspring was tested in a series of behavioral tests: open field test (OFT), elevated plus maze (EPM) and forced swimming test (FST). Additionally, monoamine concentrations were determined post-mortem in three brain regions: hippocampus, ventral striatum and prefrontal cortex. Our findings suggest that maternal care variations have an effect on several anxiety-related behaviors in OFT and EPM but not in depression-like behaviors in FST. Such behavioral differences could be related to an increased DOPAC concentration and 5-HT turnover in prefrontal cortex. These evidences suggest that natural variations in maternal care modified some behavioral and neurochemical parameters related with anxiety and stress in this strain.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>23711565</pmid><doi>10.1016/j.physbeh.2013.05.033</doi><tpages>6</tpages></addata></record> |
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| ispartof | Physiology & behavior, 2013-06, Vol.118, p.212-217 |
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| subjects | Animals Anxiety Anxiety - physiopathology Anxiety - psychology Behavior, Animal - physiology Behavioral psychophysiology Biogenic Monoamines - metabolism Biological and medical sciences Brain Chemistry - physiology Chromatography, High Pressure Liquid cortex Data Interpretation, Statistical Dopamine - metabolism Electrochemistry Electrodes, Implanted Female Fundamental and applied biological sciences. Psychology Grooming Grooming behavior hippocampus Hippocampus - metabolism Hydroxyindoleacetic Acid - metabolism Maternal Behavior - physiology Maternal care Monoamines mothers Motor Activity - physiology Neostriatum - metabolism Neurotransmitter Agents - metabolism Prefrontal Cortex - metabolism progeny Psychiatry Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Sprague-Dawley Restraint, Physical - physiology Restraint, Physical - psychology serotonin Serotonin - metabolism Sprague–Dawley Stress response Stress, Psychological - physiopathology Stress, Psychological - psychology swimming Swimming - psychology |
| title | Behavioral and neurochemical characterization of maternal care effects on juvenile Sprague–Dawley rats |
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