Early T-cell precursor leukemia/lymphoma in adults and children
Abstract Early T-cell precursor-ALL (ETP-ALL) is a subtype of T-ALL with a poor prognosis in children. We analyzed ETP-ALL compared to conventional T-ALL/LBL in both adults and children to determine any differences in clinical outcomes, based on the following parameters: induction failure, relapse,...
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| Veröffentlicht in: | Leukemia research 2013-09, Vol.37 (9), p.1027-1034 |
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| container_title | Leukemia research |
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| creator | Allen, Ashleigh Sireci, Anthony Colovai, Adrianna Pinkney, Kerice Sulis, Maria Bhagat, Govind Alobeid, Bachir |
| description | Abstract Early T-cell precursor-ALL (ETP-ALL) is a subtype of T-ALL with a poor prognosis in children. We analyzed ETP-ALL compared to conventional T-ALL/LBL in both adults and children to determine any differences in clinical outcomes, based on the following parameters: induction failure, relapse, and survival. Patients with ETP-ALL have a higher risk of relapse, especially in children (in all patients, HR = 4.08, p = 0.127, and children, HR = 11.63, p = 0.025). ETP-ALL seems to have an increased risk of adverse outcomes, particularly in children. Larger studies are needed to better determine the prognosis of this subtype of T-ALL. |
| doi_str_mv | 10.1016/j.leukres.2013.06.010 |
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We analyzed ETP-ALL compared to conventional T-ALL/LBL in both adults and children to determine any differences in clinical outcomes, based on the following parameters: induction failure, relapse, and survival. Patients with ETP-ALL have a higher risk of relapse, especially in children (in all patients, HR = 4.08, p = 0.127, and children, HR = 11.63, p = 0.025). ETP-ALL seems to have an increased risk of adverse outcomes, particularly in children. Larger studies are needed to better determine the prognosis of this subtype of T-ALL.</description><identifier>ISSN: 0145-2126</identifier><identifier>EISSN: 1873-5835</identifier><identifier>DOI: 10.1016/j.leukres.2013.06.010</identifier><identifier>PMID: 23827350</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Acute leukemia ; Adolescent ; Adult ; Adults ; Aged ; ALL ; Child ; Child, Preschool ; Children ; Cytogenetic Analysis ; Early T-cell precursors ; Female ; Flow Cytometry ; Follow-Up Studies ; Hematology, Oncology and Palliative Medicine ; Humans ; Immunophenotyping ; Infant ; Leukemia ; Lymphoblastic ; Lymphoma ; Male ; Middle Aged ; Neoplasm Recurrence, Local - genetics ; Neoplasm Recurrence, Local - mortality ; Neoplasm Recurrence, Local - therapy ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - mortality ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - therapy ; Prognosis ; Remission Induction ; Survival Rate ; Young Adult</subject><ispartof>Leukemia research, 2013-09, Vol.37 (9), p.1027-1034</ispartof><rights>Elsevier Ltd</rights><rights>2013 Elsevier Ltd</rights><rights>Copyright © 2013 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-957bed38ad77d04f93c441d542a1188441c27e0147820eb6aca59a360729c6ab3</citedby><cites>FETCH-LOGICAL-c453t-957bed38ad77d04f93c441d542a1188441c27e0147820eb6aca59a360729c6ab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.leukres.2013.06.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23827350$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Allen, Ashleigh</creatorcontrib><creatorcontrib>Sireci, Anthony</creatorcontrib><creatorcontrib>Colovai, Adrianna</creatorcontrib><creatorcontrib>Pinkney, Kerice</creatorcontrib><creatorcontrib>Sulis, Maria</creatorcontrib><creatorcontrib>Bhagat, Govind</creatorcontrib><creatorcontrib>Alobeid, Bachir</creatorcontrib><title>Early T-cell precursor leukemia/lymphoma in adults and children</title><title>Leukemia research</title><addtitle>Leuk Res</addtitle><description>Abstract Early T-cell precursor-ALL (ETP-ALL) is a subtype of T-ALL with a poor prognosis in children. We analyzed ETP-ALL compared to conventional T-ALL/LBL in both adults and children to determine any differences in clinical outcomes, based on the following parameters: induction failure, relapse, and survival. Patients with ETP-ALL have a higher risk of relapse, especially in children (in all patients, HR = 4.08, p = 0.127, and children, HR = 11.63, p = 0.025). ETP-ALL seems to have an increased risk of adverse outcomes, particularly in children. Larger studies are needed to better determine the prognosis of this subtype of T-ALL.</description><subject>Acute leukemia</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Adults</subject><subject>Aged</subject><subject>ALL</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Cytogenetic Analysis</subject><subject>Early T-cell precursors</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Follow-Up Studies</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Immunophenotyping</subject><subject>Infant</subject><subject>Leukemia</subject><subject>Lymphoblastic</subject><subject>Lymphoma</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - genetics</subject><subject>Neoplasm Recurrence, Local - mortality</subject><subject>Neoplasm Recurrence, Local - therapy</subject><subject>Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics</subject><subject>Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - mortality</subject><subject>Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - therapy</subject><subject>Prognosis</subject><subject>Remission Induction</subject><subject>Survival Rate</subject><subject>Young Adult</subject><issn>0145-2126</issn><issn>1873-5835</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkT1v3DAMhoWiQXJN8xNaeOxih5QsS14aFEH6AQTokHQWdBIP0UW2r9I5wP37yrhrhy6ZyOHhS-IhYx8QGgTsrrdNpPk5UW44oGigawDhDVuhVqKWWsi3bAXYypoj7y7Yu5y3ACB77M_ZBReaKyFhxW7ubIqH6rF2FGO1S-TmlKdULeE0BHsdD8PuaRpsFcbK-jnuc2VHX7mnEH2i8T0729iY6epUL9mvr3ePt9_r-5_fftx-ua9dK8W-7qVakxfaeqU8tJteuLZFL1tuEbUuveOKyr1Kc6B1Z52VvRUdKN67zq7FJft0zN2l6fdMeW-GkJeb7UjTnA1KACV7ocXraItKCg66Lag8oi5NOSfamF0Kg00Hg2AWzWZrTprNotlAZ4rmMvfxtGJeD-T_Tf31WoCbI0DFyUugZLILNDryoSjeGz-FV1d8_i_BxTAGZ-MzHShvpzmNRbhBk7kB87D8enk1CgDsOyH-AHKfo-k</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Allen, Ashleigh</creator><creator>Sireci, Anthony</creator><creator>Colovai, Adrianna</creator><creator>Pinkney, Kerice</creator><creator>Sulis, Maria</creator><creator>Bhagat, Govind</creator><creator>Alobeid, Bachir</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20130901</creationdate><title>Early T-cell precursor leukemia/lymphoma in adults and children</title><author>Allen, Ashleigh ; Sireci, Anthony ; Colovai, Adrianna ; Pinkney, Kerice ; Sulis, Maria ; Bhagat, Govind ; Alobeid, Bachir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-957bed38ad77d04f93c441d542a1188441c27e0147820eb6aca59a360729c6ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acute leukemia</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Adults</topic><topic>Aged</topic><topic>ALL</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Cytogenetic Analysis</topic><topic>Early T-cell precursors</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Follow-Up Studies</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Immunophenotyping</topic><topic>Infant</topic><topic>Leukemia</topic><topic>Lymphoblastic</topic><topic>Lymphoma</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - genetics</topic><topic>Neoplasm Recurrence, Local - mortality</topic><topic>Neoplasm Recurrence, Local - therapy</topic><topic>Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics</topic><topic>Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - mortality</topic><topic>Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - therapy</topic><topic>Prognosis</topic><topic>Remission Induction</topic><topic>Survival Rate</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Allen, Ashleigh</creatorcontrib><creatorcontrib>Sireci, Anthony</creatorcontrib><creatorcontrib>Colovai, Adrianna</creatorcontrib><creatorcontrib>Pinkney, Kerice</creatorcontrib><creatorcontrib>Sulis, Maria</creatorcontrib><creatorcontrib>Bhagat, Govind</creatorcontrib><creatorcontrib>Alobeid, Bachir</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Leukemia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Allen, Ashleigh</au><au>Sireci, Anthony</au><au>Colovai, Adrianna</au><au>Pinkney, Kerice</au><au>Sulis, Maria</au><au>Bhagat, Govind</au><au>Alobeid, Bachir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early T-cell precursor leukemia/lymphoma in adults and children</atitle><jtitle>Leukemia research</jtitle><addtitle>Leuk Res</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>37</volume><issue>9</issue><spage>1027</spage><epage>1034</epage><pages>1027-1034</pages><issn>0145-2126</issn><eissn>1873-5835</eissn><abstract>Abstract Early T-cell precursor-ALL (ETP-ALL) is a subtype of T-ALL with a poor prognosis in children. We analyzed ETP-ALL compared to conventional T-ALL/LBL in both adults and children to determine any differences in clinical outcomes, based on the following parameters: induction failure, relapse, and survival. Patients with ETP-ALL have a higher risk of relapse, especially in children (in all patients, HR = 4.08, p = 0.127, and children, HR = 11.63, p = 0.025). ETP-ALL seems to have an increased risk of adverse outcomes, particularly in children. Larger studies are needed to better determine the prognosis of this subtype of T-ALL.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>23827350</pmid><doi>10.1016/j.leukres.2013.06.010</doi><tpages>8</tpages></addata></record> |
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| subjects | Acute leukemia Adolescent Adult Adults Aged ALL Child Child, Preschool Children Cytogenetic Analysis Early T-cell precursors Female Flow Cytometry Follow-Up Studies Hematology, Oncology and Palliative Medicine Humans Immunophenotyping Infant Leukemia Lymphoblastic Lymphoma Male Middle Aged Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - therapy Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - mortality Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - therapy Prognosis Remission Induction Survival Rate Young Adult |
| title | Early T-cell precursor leukemia/lymphoma in adults and children |
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