Promotion effect of constituents from the root of Polygonum multiflorum on hair growth
Two new compounds, gallic acid ester of torachrysone-8-O-β-d-glucoside (1) and (E)-2,3,5,4′-tetrahydroxystilbene-2-O-β-d-xyloside (4), along with eight known compounds (2, 3, 5–10) were isolated from a 70% ethanol extract of Polygonum multiflorum roots. Extracts of P. multiflorum have been reported...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2013-09, Vol.23 (17), p.4801-4805 |
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| creator | Sun, Ya Nan Cui, Long Li, Wei Yan, Xi Tao Yang, Seo Young Kang, Jung Il Kang, Hee Kyoung Kim, Young Ho |
| description | Two new compounds, gallic acid ester of torachrysone-8-O-β-d-glucoside (1) and (E)-2,3,5,4′-tetrahydroxystilbene-2-O-β-d-xyloside (4), along with eight known compounds (2, 3, 5–10) were isolated from a 70% ethanol extract of Polygonum multiflorum roots. Extracts of P. multiflorum have been reported to promote hair growth in vivo. This study was carried out to evaluate the effects of isolated compounds from P. multiflorum on promoting hair growth using dermal papilla cells (DPCs), which play an important role in hair growth. When DPCs were treated with compounds (1–10) from P. multiflorum, compounds 1, 2, 3, 6, and 10 increased the proliferation of DPCs compared with the control. Specifically, compound 2 (10 and 20μM) induced a greater increase in the proliferation of DPCs than minoxidil (10μM). Additionally, treatment of vibrissa follicles with compound 2 for 21days increased hair-fiber length significantly.
Two new compounds, gallic acid ester of torachrysone-8-O-β-d-glucoside (1) and (E)-2,3,5,4′-tetrahydroxystilbene-2-O-β-d-xyloside (4), along with eight known compounds (2, 3, 5–10) were isolated from a 70% ethanol extract of Polygonum multiflorum roots. The structures were determined by 1H and 13C NMR, HMQC, and HMBC spectrometry. Extracts of P. multiflorum have been reported to promote hair growth in vivo. This study was carried out to evaluate the effects of isolated compounds from P. multiflorum on promoting hair growth using dermal papilla cells (DPCs), which play an important role in hair growth. When DPCs were treated with compounds (1–10) from P. multiflorum, compounds 1, 2, 3, 6, and 10 increased the proliferation of DPCs compared with the control. Specifically, compound 2 (10 and 20μM) induced a greater increase in the proliferation of DPCs than minoxidil (10μM). Additionally, treatment of vibrissa follicles with compound 2 for 21days increased hair-fiber length significantly. On the basis of this result, further investigation and optimization of these derivatives might help in the development of therapeutic agents for the treatment of alopecia. |
| doi_str_mv | 10.1016/j.bmcl.2013.06.098 |
| format | Article |
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Two new compounds, gallic acid ester of torachrysone-8-O-β-d-glucoside (1) and (E)-2,3,5,4′-tetrahydroxystilbene-2-O-β-d-xyloside (4), along with eight known compounds (2, 3, 5–10) were isolated from a 70% ethanol extract of Polygonum multiflorum roots. The structures were determined by 1H and 13C NMR, HMQC, and HMBC spectrometry. Extracts of P. multiflorum have been reported to promote hair growth in vivo. This study was carried out to evaluate the effects of isolated compounds from P. multiflorum on promoting hair growth using dermal papilla cells (DPCs), which play an important role in hair growth. When DPCs were treated with compounds (1–10) from P. multiflorum, compounds 1, 2, 3, 6, and 10 increased the proliferation of DPCs compared with the control. Specifically, compound 2 (10 and 20μM) induced a greater increase in the proliferation of DPCs than minoxidil (10μM). Additionally, treatment of vibrissa follicles with compound 2 for 21days increased hair-fiber length significantly. On the basis of this result, further investigation and optimization of these derivatives might help in the development of therapeutic agents for the treatment of alopecia.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2013.06.098</identifier><identifier>PMID: 23896496</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>alopecia ; Animals ; Cell Proliferation - drug effects ; chemistry ; Dermal papilla cells (DPCs) ; Dermis - cytology ; Dermis - drug effects ; ethanol ; gallic acid ; Glucosides - chemistry ; Glucosides - isolation & purification ; Glucosides - pharmacology ; Glycosides - chemistry ; Glycosides - isolation & purification ; Glycosides - pharmacology ; Hair - cytology ; Hair - drug effects ; Hair - growth & development ; Hair Follicle - cytology ; Hair Follicle - drug effects ; Hair Follicle - growth & development ; Hair growth ; Hair-fiber length ; Humans ; nuclear magnetic resonance spectroscopy ; Plant Extracts - chemistry ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Plant Roots - chemistry ; Polygonum - chemistry ; Polygonum multiflorum ; Rats ; Rats, Wistar ; roots</subject><ispartof>Bioorganic & medicinal chemistry letters, 2013-09, Vol.23 (17), p.4801-4805</ispartof><rights>2013</rights><rights>Copyright © 2013 The Authors. Published by Elsevier Ltd.. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-cb32eb7b73fda13e1c633ecc694b22660c4d8bbe9f0d896e37154d4573e8999c3</citedby><cites>FETCH-LOGICAL-c413t-cb32eb7b73fda13e1c633ecc694b22660c4d8bbe9f0d896e37154d4573e8999c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bmcl.2013.06.098$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23896496$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Ya Nan</creatorcontrib><creatorcontrib>Cui, Long</creatorcontrib><creatorcontrib>Li, Wei</creatorcontrib><creatorcontrib>Yan, Xi Tao</creatorcontrib><creatorcontrib>Yang, Seo Young</creatorcontrib><creatorcontrib>Kang, Jung Il</creatorcontrib><creatorcontrib>Kang, Hee Kyoung</creatorcontrib><creatorcontrib>Kim, Young Ho</creatorcontrib><title>Promotion effect of constituents from the root of Polygonum multiflorum on hair growth</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>Two new compounds, gallic acid ester of torachrysone-8-O-β-d-glucoside (1) and (E)-2,3,5,4′-tetrahydroxystilbene-2-O-β-d-xyloside (4), along with eight known compounds (2, 3, 5–10) were isolated from a 70% ethanol extract of Polygonum multiflorum roots. Extracts of P. multiflorum have been reported to promote hair growth in vivo. This study was carried out to evaluate the effects of isolated compounds from P. multiflorum on promoting hair growth using dermal papilla cells (DPCs), which play an important role in hair growth. When DPCs were treated with compounds (1–10) from P. multiflorum, compounds 1, 2, 3, 6, and 10 increased the proliferation of DPCs compared with the control. Specifically, compound 2 (10 and 20μM) induced a greater increase in the proliferation of DPCs than minoxidil (10μM). Additionally, treatment of vibrissa follicles with compound 2 for 21days increased hair-fiber length significantly.
Two new compounds, gallic acid ester of torachrysone-8-O-β-d-glucoside (1) and (E)-2,3,5,4′-tetrahydroxystilbene-2-O-β-d-xyloside (4), along with eight known compounds (2, 3, 5–10) were isolated from a 70% ethanol extract of Polygonum multiflorum roots. The structures were determined by 1H and 13C NMR, HMQC, and HMBC spectrometry. Extracts of P. multiflorum have been reported to promote hair growth in vivo. This study was carried out to evaluate the effects of isolated compounds from P. multiflorum on promoting hair growth using dermal papilla cells (DPCs), which play an important role in hair growth. When DPCs were treated with compounds (1–10) from P. multiflorum, compounds 1, 2, 3, 6, and 10 increased the proliferation of DPCs compared with the control. Specifically, compound 2 (10 and 20μM) induced a greater increase in the proliferation of DPCs than minoxidil (10μM). Additionally, treatment of vibrissa follicles with compound 2 for 21days increased hair-fiber length significantly. On the basis of this result, further investigation and optimization of these derivatives might help in the development of therapeutic agents for the treatment of alopecia.</description><subject>alopecia</subject><subject>Animals</subject><subject>Cell Proliferation - drug effects</subject><subject>chemistry</subject><subject>Dermal papilla cells (DPCs)</subject><subject>Dermis - cytology</subject><subject>Dermis - drug effects</subject><subject>ethanol</subject><subject>gallic acid</subject><subject>Glucosides - chemistry</subject><subject>Glucosides - isolation & purification</subject><subject>Glucosides - pharmacology</subject><subject>Glycosides - chemistry</subject><subject>Glycosides - isolation & purification</subject><subject>Glycosides - pharmacology</subject><subject>Hair - cytology</subject><subject>Hair - drug effects</subject><subject>Hair - growth & development</subject><subject>Hair Follicle - cytology</subject><subject>Hair Follicle - drug effects</subject><subject>Hair Follicle - growth & development</subject><subject>Hair growth</subject><subject>Hair-fiber length</subject><subject>Humans</subject><subject>nuclear magnetic resonance spectroscopy</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Roots - chemistry</subject><subject>Polygonum - chemistry</subject><subject>Polygonum multiflorum</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>roots</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1O3DAURi1UVAbaF2BBs2STcB07Tix1UyF-KiExUkvVnZU41zMeJTHYTqt5ezwd6BJWtuRzP386l5BTCgUFKi42RTfqoSiBsgJEAbI5IAvKBc8Zh-oDWYAUkDeS_z4ixyFsACgHzj-So5I1UnApFuTX0rvRReumDI1BHTNnMu2mEG2ccYohMwnI4hoz79y_16Ubtis3zWM2zkO0ZnA-3VPAurU-W3n3N64_kUPTDgE_v5wn5OH66uflbX53f_P98ttdrjllMdcdK7Gru5qZvqUMqRaModZC8q4shQDN-6brUBroU2NkNa14z6uaYSOl1OyEnO9zH717mjFENdqgcRjaCd0cFK0A6qoBVr2PcioZT7_KhJZ7VHsXgkejHr0dW79VFNROvdqonXq1U69AqKQ-DZ295M_diP3_kVfXCfiyB0zrVLvyNqiHHykhVaSsZBUk4uuewKTsj0WvgrY4aeytT6tRvbNvNXgG_vyezQ</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Sun, Ya Nan</creator><creator>Cui, Long</creator><creator>Li, Wei</creator><creator>Yan, Xi Tao</creator><creator>Yang, Seo Young</creator><creator>Kang, Jung Il</creator><creator>Kang, Hee Kyoung</creator><creator>Kim, Young Ho</creator><general>Elsevier Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20130901</creationdate><title>Promotion effect of constituents from the root of Polygonum multiflorum on hair growth</title><author>Sun, Ya Nan ; Cui, Long ; Li, Wei ; Yan, Xi Tao ; Yang, Seo Young ; Kang, Jung Il ; Kang, Hee Kyoung ; Kim, Young Ho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-cb32eb7b73fda13e1c633ecc694b22660c4d8bbe9f0d896e37154d4573e8999c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>alopecia</topic><topic>Animals</topic><topic>Cell Proliferation - drug effects</topic><topic>chemistry</topic><topic>Dermal papilla cells (DPCs)</topic><topic>Dermis - cytology</topic><topic>Dermis - drug effects</topic><topic>ethanol</topic><topic>gallic acid</topic><topic>Glucosides - chemistry</topic><topic>Glucosides - isolation & purification</topic><topic>Glucosides - pharmacology</topic><topic>Glycosides - chemistry</topic><topic>Glycosides - isolation & purification</topic><topic>Glycosides - pharmacology</topic><topic>Hair - cytology</topic><topic>Hair - drug effects</topic><topic>Hair - growth & development</topic><topic>Hair Follicle - cytology</topic><topic>Hair Follicle - drug effects</topic><topic>Hair Follicle - growth & development</topic><topic>Hair growth</topic><topic>Hair-fiber length</topic><topic>Humans</topic><topic>nuclear magnetic resonance spectroscopy</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Roots - chemistry</topic><topic>Polygonum - chemistry</topic><topic>Polygonum multiflorum</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>roots</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Ya Nan</creatorcontrib><creatorcontrib>Cui, Long</creatorcontrib><creatorcontrib>Li, Wei</creatorcontrib><creatorcontrib>Yan, Xi Tao</creatorcontrib><creatorcontrib>Yang, Seo Young</creatorcontrib><creatorcontrib>Kang, Jung Il</creatorcontrib><creatorcontrib>Kang, Hee Kyoung</creatorcontrib><creatorcontrib>Kim, Young Ho</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Ya Nan</au><au>Cui, Long</au><au>Li, Wei</au><au>Yan, Xi Tao</au><au>Yang, Seo Young</au><au>Kang, Jung Il</au><au>Kang, Hee Kyoung</au><au>Kim, Young Ho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Promotion effect of constituents from the root of Polygonum multiflorum on hair growth</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>23</volume><issue>17</issue><spage>4801</spage><epage>4805</epage><pages>4801-4805</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>Two new compounds, gallic acid ester of torachrysone-8-O-β-d-glucoside (1) and (E)-2,3,5,4′-tetrahydroxystilbene-2-O-β-d-xyloside (4), along with eight known compounds (2, 3, 5–10) were isolated from a 70% ethanol extract of Polygonum multiflorum roots. Extracts of P. multiflorum have been reported to promote hair growth in vivo. This study was carried out to evaluate the effects of isolated compounds from P. multiflorum on promoting hair growth using dermal papilla cells (DPCs), which play an important role in hair growth. When DPCs were treated with compounds (1–10) from P. multiflorum, compounds 1, 2, 3, 6, and 10 increased the proliferation of DPCs compared with the control. Specifically, compound 2 (10 and 20μM) induced a greater increase in the proliferation of DPCs than minoxidil (10μM). Additionally, treatment of vibrissa follicles with compound 2 for 21days increased hair-fiber length significantly.
Two new compounds, gallic acid ester of torachrysone-8-O-β-d-glucoside (1) and (E)-2,3,5,4′-tetrahydroxystilbene-2-O-β-d-xyloside (4), along with eight known compounds (2, 3, 5–10) were isolated from a 70% ethanol extract of Polygonum multiflorum roots. The structures were determined by 1H and 13C NMR, HMQC, and HMBC spectrometry. Extracts of P. multiflorum have been reported to promote hair growth in vivo. This study was carried out to evaluate the effects of isolated compounds from P. multiflorum on promoting hair growth using dermal papilla cells (DPCs), which play an important role in hair growth. When DPCs were treated with compounds (1–10) from P. multiflorum, compounds 1, 2, 3, 6, and 10 increased the proliferation of DPCs compared with the control. Specifically, compound 2 (10 and 20μM) induced a greater increase in the proliferation of DPCs than minoxidil (10μM). Additionally, treatment of vibrissa follicles with compound 2 for 21days increased hair-fiber length significantly. On the basis of this result, further investigation and optimization of these derivatives might help in the development of therapeutic agents for the treatment of alopecia.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>23896496</pmid><doi>10.1016/j.bmcl.2013.06.098</doi><tpages>5</tpages></addata></record> |
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| subjects | alopecia Animals Cell Proliferation - drug effects chemistry Dermal papilla cells (DPCs) Dermis - cytology Dermis - drug effects ethanol gallic acid Glucosides - chemistry Glucosides - isolation & purification Glucosides - pharmacology Glycosides - chemistry Glycosides - isolation & purification Glycosides - pharmacology Hair - cytology Hair - drug effects Hair - growth & development Hair Follicle - cytology Hair Follicle - drug effects Hair Follicle - growth & development Hair growth Hair-fiber length Humans nuclear magnetic resonance spectroscopy Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Roots - chemistry Polygonum - chemistry Polygonum multiflorum Rats Rats, Wistar roots |
| title | Promotion effect of constituents from the root of Polygonum multiflorum on hair growth |
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