2-Aminothiazole based P2Y1 antagonists as novel antiplatelet agents
ADP receptors, P2Y1 and P2Y12 have been recognized as potential targets for antithrombotic drugs. A series of P2Y1 antagonists that contain 2-aminothiazoles as urea surrogates were discovered. Extensive SAR of the thiazole ring is described. The most potent compound 7j showed good P2Y1 binding (Ki=1...
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Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2013-07, Vol.23 (14), p.4206-4209 |
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