Structure–activity relationship study of phenylpyrazole derivatives as a novel class of anti-HIV agents

The structure–activity relationship of phenylpyrazole derivative 1 was investigated for the development of novel anti-HIV agents. Initial efforts revealed that the diazenyl group can be replaced by an aminomethylene group. In addition, we synthesized various derivatives by the reductive amination of...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2013-08, Vol.23 (16), p.4557-4561
Hauptverfasser:	Mizuhara, Tsukasa, Kato, Takayuki, Hirai, Atsushi, Kurihara, Hideki, Shimada, Yasuhiro, Taniguchi, Masahiko, Maeta, Hideki, Togami, Hiroaki, Shimura, Kazuya, Matsuoka, Masao, Okazaki, Shiho, Takeuchi, Tomoki, Ohno, Hiroaki, Oishi, Shinya, Fujii, Nobutaka
Format:	Artikel
Sprache:	eng
Schlagworte:	amino acid derivatives Anti-HIV agent Anti-HIV Agents - chemical synthesis Anti-HIV Agents - chemistry Anti-HIV Agents - pharmacology antiretroviral agents antiviral properties Benzene Derivatives - chemical synthesis Benzene Derivatives - chemistry Benzene Derivatives - pharmacology HIV - drug effects Human immunodeficiency virus Inhibitory Concentration 50 Phenylpyrazole pyrazoles Pyrazoles - chemical synthesis Pyrazoles - chemistry Pyrazoles - pharmacology Structure-Activity Relationship structure-activity relationships
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