Supplementation with Astragalus polysaccharides alters Aeromonas-induced tissue-specific cellular immune response
Members of the genus Aeromonas inhabit various aquatic environments and are responsible for a number of intestinal and extra-intestinal infections in humans as well as other animals. Astragalus species are used in Chinese traditional medicine as antiperspirant, antihypertensive, diuretic and tonic t...
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| Veröffentlicht in: | Microbial pathogenesis 2014-01, Vol.66, p.48-56 |
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| description | Members of the genus Aeromonas inhabit various aquatic environments and are responsible for a number of intestinal and extra-intestinal infections in humans as well as other animals. Astragalus species are used in Chinese traditional medicine as antiperspirant, antihypertensive, diuretic and tonic treatments and have been used for treatment of patients with leukemia and uterine cancers. The present study was aimed to investigate immunomodulatory effect of Astragalus polysaccharides (APS) treatment on Aeromonas hydrophila-infected mice. The present data showed that APS-treatment ameliorated neutrophils phagocytic activity and reactive oxygen species (ROS) production in intestinal tissues of infected mice. Moreover, APS treatment induced a highly significantly (P |
| doi_str_mv | 10.1016/j.micpath.2013.12.005 |
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•Aeromonas hydrophila increases phagocytosis and reactive oxygen species production.•Astragalus treatment increases CD4+ T-cells of intestinal lymphocytes and thymocytes.•Astragalus decreases CD8+ T-cells in both the spleen and thymus.•Astragalus-treatment prevents hepatic injury and protects hepatocytes.</description><identifier>ISSN: 0882-4010</identifier><identifier>EISSN: 1096-1208</identifier><identifier>DOI: 10.1016/j.micpath.2013.12.005</identifier><identifier>PMID: 24456824</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Aeromonas ; Aeromonas hydrophila ; Animals ; Astragalus Plant - chemistry ; Astragalus polysaccharides ; CD4+/CD8+ T cells ; CD4-CD8 Ratio ; Gram-Negative Bacterial Infections - immunology ; Immunity, Cellular - drug effects ; Intestines - cytology ; Intestines - drug effects ; Intestines - metabolism ; Male ; Mice ; Neutrophils - immunology ; Phagocytic index ; Phagocytosis ; Polysaccharides - pharmacology ; Reactive Oxygen Species - metabolism ; Spleen - drug effects ; Spleen - immunology ; Thymus Gland - drug effects ; Thymus Gland - metabolism</subject><ispartof>Microbial pathogenesis, 2014-01, Vol.66, p.48-56</ispartof><rights>2014 Elsevier Ltd</rights><rights>Copyright © 2014 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-3dc338992299848f8d74d16df9fdff2d89e2c2f9bbc588d0790847a7069999f03</citedby><cites>FETCH-LOGICAL-c365t-3dc338992299848f8d74d16df9fdff2d89e2c2f9bbc588d0790847a7069999f03</cites><orcidid>0000-0001-8244-9124</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.micpath.2013.12.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24456824$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abuelsaad, Abdelaziz S.A.</creatorcontrib><title>Supplementation with Astragalus polysaccharides alters Aeromonas-induced tissue-specific cellular immune response</title><title>Microbial pathogenesis</title><addtitle>Microb Pathog</addtitle><description>Members of the genus Aeromonas inhabit various aquatic environments and are responsible for a number of intestinal and extra-intestinal infections in humans as well as other animals. Astragalus species are used in Chinese traditional medicine as antiperspirant, antihypertensive, diuretic and tonic treatments and have been used for treatment of patients with leukemia and uterine cancers. The present study was aimed to investigate immunomodulatory effect of Astragalus polysaccharides (APS) treatment on Aeromonas hydrophila-infected mice. The present data showed that APS-treatment ameliorated neutrophils phagocytic activity and reactive oxygen species (ROS) production in intestinal tissues of infected mice. Moreover, APS treatment induced a highly significantly (P < 0.001) increase in the number of CD4+ T cells in the intestinal tissues and thymus, however, number of CD4+ T cells in the spleens of infected mice not significantly changed with APS treatment. On the other hand, APS-treatment caused a very highly significant (P < 0.001) decrease in the number of CD8+ T cells in the spleens and thymus of infected mice. In conclusion, the present data suggested that APS treatment reduced ROS production, downmodulated neutrophils activity, and increased CD4+/CD8+ T cells ratio in A. hydrophila-infected mice.
•Aeromonas hydrophila increases phagocytosis and reactive oxygen species production.•Astragalus treatment increases CD4+ T-cells of intestinal lymphocytes and thymocytes.•Astragalus decreases CD8+ T-cells in both the spleen and thymus.•Astragalus-treatment prevents hepatic injury and protects hepatocytes.</description><subject>Aeromonas</subject><subject>Aeromonas hydrophila</subject><subject>Animals</subject><subject>Astragalus Plant - chemistry</subject><subject>Astragalus polysaccharides</subject><subject>CD4+/CD8+ T cells</subject><subject>CD4-CD8 Ratio</subject><subject>Gram-Negative Bacterial Infections - immunology</subject><subject>Immunity, Cellular - drug effects</subject><subject>Intestines - cytology</subject><subject>Intestines - drug effects</subject><subject>Intestines - metabolism</subject><subject>Male</subject><subject>Mice</subject><subject>Neutrophils - immunology</subject><subject>Phagocytic index</subject><subject>Phagocytosis</subject><subject>Polysaccharides - pharmacology</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Spleen - drug effects</subject><subject>Spleen - immunology</subject><subject>Thymus Gland - drug effects</subject><subject>Thymus Gland - metabolism</subject><issn>0882-4010</issn><issn>1096-1208</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDmPFDEQRi0EYoeFnwBySNJN2X3ZERqtuKSVCIDY8thlxqO-1mWD9t_ToxlIqaSS99XxGHstoBYg-neneoputflYSxBNLWQN0D1hOwG6r4QE9ZTtQClZtSDghr0gOgGAbhv9nN3Itu16Jdsde_hW1nXECedsc1xm_jvmI99TTvanHQvxdRkfyTp3tCl6JG7HjIn4HtMyLbOlKs6-OPQ8R6KCFa3oYoiOOxzHMtrE4zSVGXlCWpeZ8CV7FuxI-Orab9mPjx--332u7r9--nK3v69c03e5arxrGqW1lFqrVgXlh9aL3gcdfAjSK43SyaAPB9cp5WHQoNrBDtDrrQI0t-ztZe6aloeClM0U6XyUnXEpZEQHG9sPoDe0u6AuLUQJg1lTnGx6NALM2bY5mattc7ZthDSb7S335rqiHCb0_1J_9W7A-wuA26O_IiZDLuK86YoJXTZ-if9Z8QfCvJZM</recordid><startdate>201401</startdate><enddate>201401</enddate><creator>Abuelsaad, Abdelaziz S.A.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8244-9124</orcidid></search><sort><creationdate>201401</creationdate><title>Supplementation with Astragalus polysaccharides alters Aeromonas-induced tissue-specific cellular immune response</title><author>Abuelsaad, Abdelaziz S.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-3dc338992299848f8d74d16df9fdff2d89e2c2f9bbc588d0790847a7069999f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aeromonas</topic><topic>Aeromonas hydrophila</topic><topic>Animals</topic><topic>Astragalus Plant - chemistry</topic><topic>Astragalus polysaccharides</topic><topic>CD4+/CD8+ T cells</topic><topic>CD4-CD8 Ratio</topic><topic>Gram-Negative Bacterial Infections - immunology</topic><topic>Immunity, Cellular - drug effects</topic><topic>Intestines - cytology</topic><topic>Intestines - drug effects</topic><topic>Intestines - metabolism</topic><topic>Male</topic><topic>Mice</topic><topic>Neutrophils - immunology</topic><topic>Phagocytic index</topic><topic>Phagocytosis</topic><topic>Polysaccharides - pharmacology</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Spleen - drug effects</topic><topic>Spleen - immunology</topic><topic>Thymus Gland - drug effects</topic><topic>Thymus Gland - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abuelsaad, Abdelaziz S.A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Microbial pathogenesis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abuelsaad, Abdelaziz S.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Supplementation with Astragalus polysaccharides alters Aeromonas-induced tissue-specific cellular immune response</atitle><jtitle>Microbial pathogenesis</jtitle><addtitle>Microb Pathog</addtitle><date>2014-01</date><risdate>2014</risdate><volume>66</volume><spage>48</spage><epage>56</epage><pages>48-56</pages><issn>0882-4010</issn><eissn>1096-1208</eissn><abstract>Members of the genus Aeromonas inhabit various aquatic environments and are responsible for a number of intestinal and extra-intestinal infections in humans as well as other animals. Astragalus species are used in Chinese traditional medicine as antiperspirant, antihypertensive, diuretic and tonic treatments and have been used for treatment of patients with leukemia and uterine cancers. The present study was aimed to investigate immunomodulatory effect of Astragalus polysaccharides (APS) treatment on Aeromonas hydrophila-infected mice. The present data showed that APS-treatment ameliorated neutrophils phagocytic activity and reactive oxygen species (ROS) production in intestinal tissues of infected mice. Moreover, APS treatment induced a highly significantly (P < 0.001) increase in the number of CD4+ T cells in the intestinal tissues and thymus, however, number of CD4+ T cells in the spleens of infected mice not significantly changed with APS treatment. On the other hand, APS-treatment caused a very highly significant (P < 0.001) decrease in the number of CD8+ T cells in the spleens and thymus of infected mice. In conclusion, the present data suggested that APS treatment reduced ROS production, downmodulated neutrophils activity, and increased CD4+/CD8+ T cells ratio in A. hydrophila-infected mice.
•Aeromonas hydrophila increases phagocytosis and reactive oxygen species production.•Astragalus treatment increases CD4+ T-cells of intestinal lymphocytes and thymocytes.•Astragalus decreases CD8+ T-cells in both the spleen and thymus.•Astragalus-treatment prevents hepatic injury and protects hepatocytes.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>24456824</pmid><doi>10.1016/j.micpath.2013.12.005</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-8244-9124</orcidid></addata></record> |
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| subjects | Aeromonas Aeromonas hydrophila Animals Astragalus Plant - chemistry Astragalus polysaccharides CD4+/CD8+ T cells CD4-CD8 Ratio Gram-Negative Bacterial Infections - immunology Immunity, Cellular - drug effects Intestines - cytology Intestines - drug effects Intestines - metabolism Male Mice Neutrophils - immunology Phagocytic index Phagocytosis Polysaccharides - pharmacology Reactive Oxygen Species - metabolism Spleen - drug effects Spleen - immunology Thymus Gland - drug effects Thymus Gland - metabolism |
| title | Supplementation with Astragalus polysaccharides alters Aeromonas-induced tissue-specific cellular immune response |
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