The effect of maternal pravastatin therapy on adverse sensorimotor outcomes of the offspring in a murine model of preeclampsia

•Human data suggest a link between preeclampsia and offspring neurologic impairment.•In our mouse model, preeclampsia impairs adult offspring sensorimotor performance.•Maternal pravastatin therapy prevents adverse sensorimotor outcomes in offspring. Animal and human studies show that in-utero exposu...

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Veröffentlicht in:	International journal of developmental neuroscience 2014-04, Vol.33 (1), p.33-40
Hauptverfasser:	Carver, Alissa R., Tamayo, Esther, Perez-Polo, J. Regino, Saade, George R., Hankins, Gary D.V., Costantine, Maged M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Anticholesteremic Agents - therapeutic use Disease Models, Animal Female Fetal Development - drug effects Fetal programming Gait Disorders, Neurologic - etiology Gait Disorders, Neurologic - prevention & control Humans Male Mice Neuromotor function Postural Balance - drug effects Pravastatin Pravastatin - therapeutic use Pre-Eclampsia - physiopathology Preeclampsia Pregnancy Prenatal Exposure Delayed Effects - etiology Prenatal Exposure Delayed Effects - prevention & control Psychomotor Disorders - etiology Psychomotor Disorders - prevention & control Reflex - drug effects Sex Factors Soluble Fms-like tyrosine kinase 1 Transduction, Genetic Vascular Endothelial Growth Factor Receptor-1 - genetics Vascular Endothelial Growth Factor Receptor-1 - metabolism
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