Tonsillar Crypt Epithelium Is an Important Extra-Central Nervous System Site for Viral Replication in EV71 Encephalomyelitis

Enterovirus 71 (EV71; family Picornaviridae, species human Enterovirus A ) usually causes hand, foot, and mouth disease, which may rarely be complicated by fatal encephalomyelitis. We investigated extra-central nervous system (extra-CNS) tissues capable of supporting EV71 infection and replication,...

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Veröffentlicht in:	The American journal of pathology 2014-03, Vol.184 (3), p.714-720
Hauptverfasser:	He, Yaoxin, Ong, Kien Chai, Gao, Zifen, Zhao, Xishun, Anderson, Virginia M, McNutt, Michael A, Wong, Kum Thong, Lu, Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Central Nervous System - virology Child Encephalomyelitis - virology Enterovirus A, Human - physiology Epithelium - virology Humans Inflammation Lysosomal Membrane Proteins - metabolism Male Membrane Glycoproteins - metabolism Mouth Palatine Tonsil - virology Pathology Receptors, Scavenger - metabolism Receptors, Virus - metabolism RNA, Viral - genetics Virus Replication Young Adult
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