A new molecule in aneurysmal subarachnoid hemorrhage: dendroaspis natriuretic peptide

Dendroaspis natriuretic peptide (DNP) is the most recently identified member of the natriuretic peptide family. Although DNP has similar structure and function to other members, it is genetically different. The other members are known to cause vasorelaxation but the effects of DNP on vascular struct...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Turkish neurosurgery 2014, Vol.24 (1), p.38-43
Hauptverfasser: Serefhan, Alpay, Altas, Murat, Cerci, Ajlan, Isik, Nejat, Elmaci, Ilhan
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 43
container_issue 1
container_start_page 38
container_title Turkish neurosurgery
container_volume 24
creator Serefhan, Alpay
Altas, Murat
Cerci, Ajlan
Isik, Nejat
Elmaci, Ilhan
description Dendroaspis natriuretic peptide (DNP) is the most recently identified member of the natriuretic peptide family. Although DNP has similar structure and function to other members, it is genetically different. The other members are known to cause vasorelaxation but the effects of DNP on vascular structure still remains unclear. In this study, we aimed to find out the role of DNP in the development of vasospasm following aneurysmal SAH (subarachnoid hemorrhage). DNP levels of 17 patients diagnosed with aneurysmal SAH and 25 volunteers as control were measured. All SAH patients were treated with aneurysm clip. Five ml of venous blood sample was obtained on postoperative 1, 3 and 7th days from each patient. Additionally, DNP levels were determined by obtaining cerebrospinal fluid (CSF) postoperative 1, 3 and 7th days. Statistically significant difference was observed between cerebrospinal fluid DNP levels on day 1 and day 3 (P < 0.05). This study suggests that DNP can be anticipated among molecules leading development of vasospasm. The findings of present study are believed to encourage further studies regarding receptors and receptor specific drugs.
doi_str_mv 10.5137/1019-5149.JTN.8016-13.2
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1500689597</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1500689597</sourcerecordid><originalsourceid>FETCH-LOGICAL-p211t-38f5db977a93ea9e2e359fa2ec6921419974e1793971cd6a1b56475e35deb6893</originalsourceid><addsrcrecordid>eNo9kMtOwzAURL0A0VL4BfCSTUJuHMe57KqK8lAFm3YdOfEtNcoLOxbq3xOJwmoWczSaGcZuIYklCHUPCWAkIcP4dfsWFwnkEYg4PWPzf2fGLr3_TJI8TwEu2CzNpJCqwDnbLXlH37ztG6pDQ9x2XHcU3NG3uuE-VNrp-tD11vADtb1zB_1BD9xQZ1yv_WA97_TobHA02poPNIzW0BU73-vG0_VJF2y3ftyunqPN-9PLarmJhqnHGIliL02FSmkUpJFSEhL3OqU6xxQyQFQZgUKBCmqTa6hknik5UYaqvECxYHe_uYPrvwL5sWytr6lppg198CXIaXOBEtWE3pzQULVkysHZVrtj-XeF-AEqEWDD</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1500689597</pqid></control><display><type>article</type><title>A new molecule in aneurysmal subarachnoid hemorrhage: dendroaspis natriuretic peptide</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Serefhan, Alpay ; Altas, Murat ; Cerci, Ajlan ; Isik, Nejat ; Elmaci, Ilhan</creator><creatorcontrib>Serefhan, Alpay ; Altas, Murat ; Cerci, Ajlan ; Isik, Nejat ; Elmaci, Ilhan</creatorcontrib><description>Dendroaspis natriuretic peptide (DNP) is the most recently identified member of the natriuretic peptide family. Although DNP has similar structure and function to other members, it is genetically different. The other members are known to cause vasorelaxation but the effects of DNP on vascular structure still remains unclear. In this study, we aimed to find out the role of DNP in the development of vasospasm following aneurysmal SAH (subarachnoid hemorrhage). DNP levels of 17 patients diagnosed with aneurysmal SAH and 25 volunteers as control were measured. All SAH patients were treated with aneurysm clip. Five ml of venous blood sample was obtained on postoperative 1, 3 and 7th days from each patient. Additionally, DNP levels were determined by obtaining cerebrospinal fluid (CSF) postoperative 1, 3 and 7th days. Statistically significant difference was observed between cerebrospinal fluid DNP levels on day 1 and day 3 (P &lt; 0.05). This study suggests that DNP can be anticipated among molecules leading development of vasospasm. The findings of present study are believed to encourage further studies regarding receptors and receptor specific drugs.</description><identifier>ISSN: 1019-5149</identifier><identifier>DOI: 10.5137/1019-5149.JTN.8016-13.2</identifier><identifier>PMID: 24535789</identifier><language>eng</language><publisher>Turkey</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Elapid Venoms - cerebrospinal fluid ; Elapid Venoms - genetics ; Female ; Humans ; Male ; Middle Aged ; Peptides - cerebrospinal fluid ; Peptides - genetics ; Subarachnoid Hemorrhage - cerebrospinal fluid ; Subarachnoid Hemorrhage - diagnostic imaging ; Subarachnoid Hemorrhage - genetics ; Ultrasonography, Doppler, Transcranial ; Vasospasm, Intracranial - etiology ; Young Adult</subject><ispartof>Turkish neurosurgery, 2014, Vol.24 (1), p.38-43</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24535789$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Serefhan, Alpay</creatorcontrib><creatorcontrib>Altas, Murat</creatorcontrib><creatorcontrib>Cerci, Ajlan</creatorcontrib><creatorcontrib>Isik, Nejat</creatorcontrib><creatorcontrib>Elmaci, Ilhan</creatorcontrib><title>A new molecule in aneurysmal subarachnoid hemorrhage: dendroaspis natriuretic peptide</title><title>Turkish neurosurgery</title><addtitle>Turk Neurosurg</addtitle><description>Dendroaspis natriuretic peptide (DNP) is the most recently identified member of the natriuretic peptide family. Although DNP has similar structure and function to other members, it is genetically different. The other members are known to cause vasorelaxation but the effects of DNP on vascular structure still remains unclear. In this study, we aimed to find out the role of DNP in the development of vasospasm following aneurysmal SAH (subarachnoid hemorrhage). DNP levels of 17 patients diagnosed with aneurysmal SAH and 25 volunteers as control were measured. All SAH patients were treated with aneurysm clip. Five ml of venous blood sample was obtained on postoperative 1, 3 and 7th days from each patient. Additionally, DNP levels were determined by obtaining cerebrospinal fluid (CSF) postoperative 1, 3 and 7th days. Statistically significant difference was observed between cerebrospinal fluid DNP levels on day 1 and day 3 (P &lt; 0.05). This study suggests that DNP can be anticipated among molecules leading development of vasospasm. The findings of present study are believed to encourage further studies regarding receptors and receptor specific drugs.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Elapid Venoms - cerebrospinal fluid</subject><subject>Elapid Venoms - genetics</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Peptides - cerebrospinal fluid</subject><subject>Peptides - genetics</subject><subject>Subarachnoid Hemorrhage - cerebrospinal fluid</subject><subject>Subarachnoid Hemorrhage - diagnostic imaging</subject><subject>Subarachnoid Hemorrhage - genetics</subject><subject>Ultrasonography, Doppler, Transcranial</subject><subject>Vasospasm, Intracranial - etiology</subject><subject>Young Adult</subject><issn>1019-5149</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtOwzAURL0A0VL4BfCSTUJuHMe57KqK8lAFm3YdOfEtNcoLOxbq3xOJwmoWczSaGcZuIYklCHUPCWAkIcP4dfsWFwnkEYg4PWPzf2fGLr3_TJI8TwEu2CzNpJCqwDnbLXlH37ztG6pDQ9x2XHcU3NG3uuE-VNrp-tD11vADtb1zB_1BD9xQZ1yv_WA97_TobHA02poPNIzW0BU73-vG0_VJF2y3ftyunqPN-9PLarmJhqnHGIliL02FSmkUpJFSEhL3OqU6xxQyQFQZgUKBCmqTa6hknik5UYaqvECxYHe_uYPrvwL5sWytr6lppg198CXIaXOBEtWE3pzQULVkysHZVrtj-XeF-AEqEWDD</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Serefhan, Alpay</creator><creator>Altas, Murat</creator><creator>Cerci, Ajlan</creator><creator>Isik, Nejat</creator><creator>Elmaci, Ilhan</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2014</creationdate><title>A new molecule in aneurysmal subarachnoid hemorrhage: dendroaspis natriuretic peptide</title><author>Serefhan, Alpay ; Altas, Murat ; Cerci, Ajlan ; Isik, Nejat ; Elmaci, Ilhan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-38f5db977a93ea9e2e359fa2ec6921419974e1793971cd6a1b56475e35deb6893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Elapid Venoms - cerebrospinal fluid</topic><topic>Elapid Venoms - genetics</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Peptides - cerebrospinal fluid</topic><topic>Peptides - genetics</topic><topic>Subarachnoid Hemorrhage - cerebrospinal fluid</topic><topic>Subarachnoid Hemorrhage - diagnostic imaging</topic><topic>Subarachnoid Hemorrhage - genetics</topic><topic>Ultrasonography, Doppler, Transcranial</topic><topic>Vasospasm, Intracranial - etiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Serefhan, Alpay</creatorcontrib><creatorcontrib>Altas, Murat</creatorcontrib><creatorcontrib>Cerci, Ajlan</creatorcontrib><creatorcontrib>Isik, Nejat</creatorcontrib><creatorcontrib>Elmaci, Ilhan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Turkish neurosurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Serefhan, Alpay</au><au>Altas, Murat</au><au>Cerci, Ajlan</au><au>Isik, Nejat</au><au>Elmaci, Ilhan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A new molecule in aneurysmal subarachnoid hemorrhage: dendroaspis natriuretic peptide</atitle><jtitle>Turkish neurosurgery</jtitle><addtitle>Turk Neurosurg</addtitle><date>2014</date><risdate>2014</risdate><volume>24</volume><issue>1</issue><spage>38</spage><epage>43</epage><pages>38-43</pages><issn>1019-5149</issn><abstract>Dendroaspis natriuretic peptide (DNP) is the most recently identified member of the natriuretic peptide family. Although DNP has similar structure and function to other members, it is genetically different. The other members are known to cause vasorelaxation but the effects of DNP on vascular structure still remains unclear. In this study, we aimed to find out the role of DNP in the development of vasospasm following aneurysmal SAH (subarachnoid hemorrhage). DNP levels of 17 patients diagnosed with aneurysmal SAH and 25 volunteers as control were measured. All SAH patients were treated with aneurysm clip. Five ml of venous blood sample was obtained on postoperative 1, 3 and 7th days from each patient. Additionally, DNP levels were determined by obtaining cerebrospinal fluid (CSF) postoperative 1, 3 and 7th days. Statistically significant difference was observed between cerebrospinal fluid DNP levels on day 1 and day 3 (P &lt; 0.05). This study suggests that DNP can be anticipated among molecules leading development of vasospasm. The findings of present study are believed to encourage further studies regarding receptors and receptor specific drugs.</abstract><cop>Turkey</cop><pmid>24535789</pmid><doi>10.5137/1019-5149.JTN.8016-13.2</doi><tpages>6</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1019-5149
ispartof Turkish neurosurgery, 2014, Vol.24 (1), p.38-43
issn 1019-5149
language eng
recordid cdi_proquest_miscellaneous_1500689597
source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects Adolescent
Adult
Aged
Aged, 80 and over
Elapid Venoms - cerebrospinal fluid
Elapid Venoms - genetics
Female
Humans
Male
Middle Aged
Peptides - cerebrospinal fluid
Peptides - genetics
Subarachnoid Hemorrhage - cerebrospinal fluid
Subarachnoid Hemorrhage - diagnostic imaging
Subarachnoid Hemorrhage - genetics
Ultrasonography, Doppler, Transcranial
Vasospasm, Intracranial - etiology
Young Adult
title A new molecule in aneurysmal subarachnoid hemorrhage: dendroaspis natriuretic peptide
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T20%3A26%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20new%20molecule%20in%20aneurysmal%20subarachnoid%20hemorrhage:%20dendroaspis%20natriuretic%20peptide&rft.jtitle=Turkish%20neurosurgery&rft.au=Serefhan,%20Alpay&rft.date=2014&rft.volume=24&rft.issue=1&rft.spage=38&rft.epage=43&rft.pages=38-43&rft.issn=1019-5149&rft_id=info:doi/10.5137/1019-5149.JTN.8016-13.2&rft_dat=%3Cproquest_pubme%3E1500689597%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1500689597&rft_id=info:pmid/24535789&rfr_iscdi=true