Mass Spectrometric Characterization of Transglutaminase Based Site-Specific Antibody–Drug Conjugates

Antibody drug conjugates (ADCs) are becoming an important new class of therapeutic agents for the treatment of cancer. ADCs are produced through the linkage of a cytotoxic small molecule (drug) to monoclonal antibodies that target tumor cells. Traditionally, most ADCs rely on chemical conjugation me...

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Veröffentlicht in:	Bioconjugate chemistry 2014-02, Vol.25 (2), p.240-250
Hauptverfasser:	Farias, Santiago E, Strop, Pavel, Delaria, Kathy, Galindo Casas, Meritxell, Dorywalska, Magdalena, Shelton, David L, Pons, Jaume, Rajpal, Arvind
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies - chemistry Biochemistry Cells Chromatography, Liquid Cytotoxicity Drugs Enzymes Mass spectrometry Molecules Pharmaceutical Preparations - chemistry Tandem Mass Spectrometry - methods Transglutaminases - chemistry Tumors
Online-Zugang:	Volltext
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