Friend or foe? Effect of oral resveratrol on cisplatin ototoxicity

Objectives/Hypothesis Our objectives were to study effects of orally administered resveratrol (RV) against cisplatin (CDDP) ototoxicity in different doses and to investigate ultrastructural changes in the cochlea and brainstem. Study Design In vivo study using an animal model. Methods Thirty‐two mal...

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Veröffentlicht in:	The Laryngoscope 2014-03, Vol.124 (3), p.760-766
Hauptverfasser:	Olgun, Yüksel, Kırkım, Günay, Kolatan, Efsun, Kıray, Müge, Bagrıyanık, Alper, Olgun, Aybüke, Kızmazoglu, Deniz Cakır, Ellıdokuz, Hülya, Serbetcıoglu, Bulent, Altun, Zekiye, Aktas, Safiye, Yılmaz, Osman, Günerı, Enis Alpin
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - toxicity Antioxidants - administration & dosage Biopsy, Needle Caspase 3 - metabolism Cisplatin Cisplatin - pharmacology Cisplatin - toxicity Disease Models, Animal Dose-Response Relationship, Drug Evoked Potentials, Auditory, Brain Stem - drug effects Hair Cells, Auditory - drug effects Hair Cells, Auditory - ultrastructure Hearing Loss, Sensorineural - chemically induced Hearing Loss, Sensorineural - prevention & control Immunohistochemistry In Situ Nick-End Labeling Laryngoscopy Male Microscopy, Electron, Transmission Otoacoustic Emissions, Spontaneous - drug effects ototoxicity Random Allocation Rats Rats, Wistar Reference Values resveratrol Stilbenes - administration & dosage Treatment Outcome
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