Recent trends in the management of minor salivary gland carcinoma
The current management of minor salivary gland cancer is reviewed. These malignancies often present as a submucosal swelling and have been reported at all anatomic subsites of the head and neck. Modern imaging is essential in evaluating the location and the anatomic extent of disease. An incisional...
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| Veröffentlicht in: | Head & neck 2014-03, Vol.36 (3), p.444-455 |
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| container_title | Head & neck |
| container_volume | 36 |
| creator | Poorten, Vincent Vander Hunt, Jennifer Bradley, Patrick J. Haigentz Jr, Missak Rinaldo, Alessandra Mendenhall, William M. Suarez, Carlos Silver, Carl Takes, Robert P. Ferlito, Alfio |
| description | The current management of minor salivary gland cancer is reviewed. These malignancies often present as a submucosal swelling and have been reported at all anatomic subsites of the head and neck. Modern imaging is essential in evaluating the location and the anatomic extent of disease. An incisional or punch biopsy determines the histologic type and grade. Recent advances in molecular biology have yielded diagnostic and potential therapeutic targets that may change our treatment in the future. Complete resection is the treatment of choice. Unfortunately, given the proximity of essential structures, the need to balance functional and cosmetic with oncologic consequences can interfere with an adequate “clear margin.” The neck should be treated when there is evidence of regional metastasis or when subclinical metastatic risk exceeds 15%. Surgery alone cures most low‐stage, low‐grade tumors, all other stages and grades require postoperative radiotherapy. Systemic treatment for locoregional and distant failure remains disappointing. © 2013 Wiley Periodicals, Inc. Head Neck 36: 444–455, 2014 |
| doi_str_mv | 10.1002/hed.23249 |
| format | Article |
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These malignancies often present as a submucosal swelling and have been reported at all anatomic subsites of the head and neck. Modern imaging is essential in evaluating the location and the anatomic extent of disease. An incisional or punch biopsy determines the histologic type and grade. Recent advances in molecular biology have yielded diagnostic and potential therapeutic targets that may change our treatment in the future. Complete resection is the treatment of choice. Unfortunately, given the proximity of essential structures, the need to balance functional and cosmetic with oncologic consequences can interfere with an adequate “clear margin.” The neck should be treated when there is evidence of regional metastasis or when subclinical metastatic risk exceeds 15%. Surgery alone cures most low‐stage, low‐grade tumors, all other stages and grades require postoperative radiotherapy. Systemic treatment for locoregional and distant failure remains disappointing. © 2013 Wiley Periodicals, Inc. 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These malignancies often present as a submucosal swelling and have been reported at all anatomic subsites of the head and neck. Modern imaging is essential in evaluating the location and the anatomic extent of disease. An incisional or punch biopsy determines the histologic type and grade. Recent advances in molecular biology have yielded diagnostic and potential therapeutic targets that may change our treatment in the future. Complete resection is the treatment of choice. Unfortunately, given the proximity of essential structures, the need to balance functional and cosmetic with oncologic consequences can interfere with an adequate “clear margin.” The neck should be treated when there is evidence of regional metastasis or when subclinical metastatic risk exceeds 15%. Surgery alone cures most low‐stage, low‐grade tumors, all other stages and grades require postoperative radiotherapy. Systemic treatment for locoregional and distant failure remains disappointing. © 2013 Wiley Periodicals, Inc. Head Neck 36: 444–455, 2014</description><subject>Biomarkers, Tumor - metabolism</subject><subject>Biopsy, Fine-Needle</subject><subject>carcinoma</subject><subject>Diagnostic Imaging</subject><subject>Humans</subject><subject>Laryngeal Neoplasms - diagnosis</subject><subject>Laryngeal Neoplasms - pathology</subject><subject>Laryngeal Neoplasms - radiotherapy</subject><subject>Laryngeal Neoplasms - surgery</subject><subject>management</subject><subject>minor salivary gland</subject><subject>Oropharyngeal Neoplasms - diagnosis</subject><subject>Oropharyngeal Neoplasms - pathology</subject><subject>Oropharyngeal Neoplasms - radiotherapy</subject><subject>Oropharyngeal Neoplasms - surgery</subject><subject>outcome</subject><subject>Prognosis</subject><subject>salivary gland neoplasms</subject><subject>Salivary Gland Neoplasms - diagnosis</subject><subject>Salivary Gland Neoplasms - pathology</subject><subject>Salivary Gland Neoplasms - radiotherapy</subject><subject>Salivary Gland Neoplasms - surgery</subject><subject>Salivary Glands, Minor</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1PwzAMhiME4mNw4A-gSlzgUEjipGmOaIwNiS8hEBKXKE1T1tGPkXTA_j0ZYxyQuNiW_fiV_SK0T_AJwZiejm1-QoEyuYa2CZYixsDE-qJmEAMWbAvteD_BGEPC6CbaosC55CTdRmf31timizpnm9xHZRN1YxvVutEvtl4M2iKqy6Z1kddV-a7dPHqpdJNHRjsT-rXeRRuFrrzd-8k99HgxeOiP4qvb4WX_7Co2jAsZZ1qklGSMM5FnLASS6YJACinLbZED1RznskgTMKDBUJpYSYqcasvB4IRBDx0tdaeufZtZ36m69MZW4RrbzrwiHOMkZTiVAT38g07amWvCdYowmUrOCReBOl5SxrXeO1uoqSvr8KEiWC18VcFX9e1rYA9-FGdZHborcmVkAE6XwEdZ2fn_Smo0OF9JxsuN0nf283dDu1eVCBBcPd0MFe_fPQOjQ3UNX6INjtA</recordid><startdate>201403</startdate><enddate>201403</enddate><creator>Poorten, Vincent Vander</creator><creator>Hunt, Jennifer</creator><creator>Bradley, Patrick J.</creator><creator>Haigentz Jr, Missak</creator><creator>Rinaldo, Alessandra</creator><creator>Mendenhall, William M.</creator><creator>Suarez, Carlos</creator><creator>Silver, Carl</creator><creator>Takes, Robert P.</creator><creator>Ferlito, Alfio</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201403</creationdate><title>Recent trends in the management of minor salivary gland carcinoma</title><author>Poorten, Vincent Vander ; 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These malignancies often present as a submucosal swelling and have been reported at all anatomic subsites of the head and neck. Modern imaging is essential in evaluating the location and the anatomic extent of disease. An incisional or punch biopsy determines the histologic type and grade. Recent advances in molecular biology have yielded diagnostic and potential therapeutic targets that may change our treatment in the future. Complete resection is the treatment of choice. Unfortunately, given the proximity of essential structures, the need to balance functional and cosmetic with oncologic consequences can interfere with an adequate “clear margin.” The neck should be treated when there is evidence of regional metastasis or when subclinical metastatic risk exceeds 15%. Surgery alone cures most low‐stage, low‐grade tumors, all other stages and grades require postoperative radiotherapy. 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| subjects | Biomarkers, Tumor - metabolism Biopsy, Fine-Needle carcinoma Diagnostic Imaging Humans Laryngeal Neoplasms - diagnosis Laryngeal Neoplasms - pathology Laryngeal Neoplasms - radiotherapy Laryngeal Neoplasms - surgery management minor salivary gland Oropharyngeal Neoplasms - diagnosis Oropharyngeal Neoplasms - pathology Oropharyngeal Neoplasms - radiotherapy Oropharyngeal Neoplasms - surgery outcome Prognosis salivary gland neoplasms Salivary Gland Neoplasms - diagnosis Salivary Gland Neoplasms - pathology Salivary Gland Neoplasms - radiotherapy Salivary Gland Neoplasms - surgery Salivary Glands, Minor |
| title | Recent trends in the management of minor salivary gland carcinoma |
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