Structural Alteration in the MYB Protooncogene and Deletion within the Gene Encoding α -Type Protein Kinase C in Human Melanoma Cell Lines
A correlative study was done to determine possible relationships between nonrandom aberrations in chromosomes 1, 6, and 7 occurring in human cutaneous malignant melanoma and the structure of oncogenes as well as specific genes encoding growth factors and growth factor receptors. Thirty cell lines de...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1988-01, Vol.85 (1), p.74-78 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Linnenbach, Alban J. Huebner, Kay Reddy, E. Premkumar Herlyn, Meenhard Parmiter, Annette H. Nowell, Peter C. Koprowski, Hilary |
| description | A correlative study was done to determine possible relationships between nonrandom aberrations in chromosomes 1, 6, and 7 occurring in human cutaneous malignant melanoma and the structure of oncogenes as well as specific genes encoding growth factors and growth factor receptors. Thirty cell lines derived from primary or metastatic melanomas of 28 patients were analyzed by Southern blotting with nicktranslated probes for 28 different genes, some of which map near frequent chromosomal breakpoints observed in melanoma. An alteration in the MYB protooncogene was observed in a cell line derived from a primary melanoma in the vertical growth phase, which correlated with a 6q22 chromosomal abnormality. Another primary melanoma cell line had a cytogenetically undetected tumor-specific deletion within the gene for α -type protein kinase C. Polymorphic alleles for the genes encoding the epidermal growth factor receptor and α -type protein kinase C were also observed. |
| doi_str_mv | 10.1073/pnas.85.1.74 |
| format | Article |
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Premkumar ; Herlyn, Meenhard ; Parmiter, Annette H. ; Nowell, Peter C. ; Koprowski, Hilary</creator><creatorcontrib>Linnenbach, Alban J. ; Huebner, Kay ; Reddy, E. Premkumar ; Herlyn, Meenhard ; Parmiter, Annette H. ; Nowell, Peter C. ; Koprowski, Hilary</creatorcontrib><description>A correlative study was done to determine possible relationships between nonrandom aberrations in chromosomes 1, 6, and 7 occurring in human cutaneous malignant melanoma and the structure of oncogenes as well as specific genes encoding growth factors and growth factor receptors. Thirty cell lines derived from primary or metastatic melanomas of 28 patients were analyzed by Southern blotting with nicktranslated probes for 28 different genes, some of which map near frequent chromosomal breakpoints observed in melanoma. An alteration in the MYB protooncogene was observed in a cell line derived from a primary melanoma in the vertical growth phase, which correlated with a 6q22 chromosomal abnormality. Another primary melanoma cell line had a cytogenetically undetected tumor-specific deletion within the gene for α -type protein kinase C. Polymorphic alleles for the genes encoding the epidermal growth factor receptor and α -type protein kinase C were also observed.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.85.1.74</identifier><identifier>PMID: 2829178</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>Alleles ; Biological and medical sciences ; Cell growth ; Cell Line ; Cell lines ; Chromosome Aberrations ; Chromosome Deletion ; Chromosomes ; Chromosomes, Human, Pair 6 ; Complementary DNA ; DNA Restriction Enzymes ; DNA, Neoplasm - genetics ; Enzymes ; Fundamental and applied biological sciences. Psychology ; Genes ; Genes. Genome ; Haplotypes ; Humans ; Melanoma ; Melanoma - enzymology ; Melanoma - genetics ; Molecular and cellular biology ; Molecular genetics ; Nucleic Acid Hybridization ; Oncogenes ; Protein Kinase C - genetics ; Proto-Oncogenes ; Tumor cell line</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1988-01, Vol.85 (1), p.74-78</ispartof><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c518t-ebb7fcbef6c3fb868846eb351afa0fd77c3a5ad03158f43899f76182b26f8c9d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/85/1.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/31009$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/31009$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,4010,27900,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7557519$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2829178$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Linnenbach, Alban J.</creatorcontrib><creatorcontrib>Huebner, Kay</creatorcontrib><creatorcontrib>Reddy, E. Premkumar</creatorcontrib><creatorcontrib>Herlyn, Meenhard</creatorcontrib><creatorcontrib>Parmiter, Annette H.</creatorcontrib><creatorcontrib>Nowell, Peter C.</creatorcontrib><creatorcontrib>Koprowski, Hilary</creatorcontrib><title>Structural Alteration in the MYB Protooncogene and Deletion within the Gene Encoding α -Type Protein Kinase C in Human Melanoma Cell Lines</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>A correlative study was done to determine possible relationships between nonrandom aberrations in chromosomes 1, 6, and 7 occurring in human cutaneous malignant melanoma and the structure of oncogenes as well as specific genes encoding growth factors and growth factor receptors. Thirty cell lines derived from primary or metastatic melanomas of 28 patients were analyzed by Southern blotting with nicktranslated probes for 28 different genes, some of which map near frequent chromosomal breakpoints observed in melanoma. An alteration in the MYB protooncogene was observed in a cell line derived from a primary melanoma in the vertical growth phase, which correlated with a 6q22 chromosomal abnormality. Another primary melanoma cell line had a cytogenetically undetected tumor-specific deletion within the gene for α -type protein kinase C. Polymorphic alleles for the genes encoding the epidermal growth factor receptor and α -type protein kinase C were also observed.</description><subject>Alleles</subject><subject>Biological and medical sciences</subject><subject>Cell growth</subject><subject>Cell Line</subject><subject>Cell lines</subject><subject>Chromosome Aberrations</subject><subject>Chromosome Deletion</subject><subject>Chromosomes</subject><subject>Chromosomes, Human, Pair 6</subject><subject>Complementary DNA</subject><subject>DNA Restriction Enzymes</subject><subject>DNA, Neoplasm - genetics</subject><subject>Enzymes</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes</subject><subject>Genes. Genome</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Melanoma</subject><subject>Melanoma - enzymology</subject><subject>Melanoma - genetics</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Nucleic Acid Hybridization</subject><subject>Oncogenes</subject><subject>Protein Kinase C - genetics</subject><subject>Proto-Oncogenes</subject><subject>Tumor cell line</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksFu1DAURS0EKkNhxwqE5AViRQY7iWN7WYbSIqYCibJgZTnOc5sqYw-2o7bfwNfwI3wTTieM2CBWb3GO73vSNUJPKVlSwqs3W6fjUrAlXfL6HlpQImnR1JLcRwtCSl6IuqwfokcxXhFCJBPkAB2UopSUiwX68SWF0aQx6AEfDQmCTr13uHc4XQI--_YWfw4-ee-MvwAHWLsOv4MB7qzrPl3O5skEj7PV9e4C__qJi_PbLdw9hqx87PORgFdT8Om40Q6fwaCd32i8gmHA695BfIweWD1EeDLPQ_T1_fH56rRYfzr5sDpaF4ZRkQpoW25NC7YxlW1FI0TdQFsxqq0mtuPcVJrpjlSUCVtXQkrLGyrKtmysMLKrDtGrXe42-O8jxKQ2fTT5DO3Aj1FxQUkjG_JfkdZS1kRO4uudaIKPMYBV29BvdLhVlKipJDWVpARTVPE66y_m3LHdQLeX51YyfzlzHY0ebNDO9HGvccY4o_IvbQr_Q-clyo5D7vMmZe35v7VMn-3oVUw-7HFF81-pfgMuCrtJ</recordid><startdate>19880101</startdate><enddate>19880101</enddate><creator>Linnenbach, Alban J.</creator><creator>Huebner, Kay</creator><creator>Reddy, E. Premkumar</creator><creator>Herlyn, Meenhard</creator><creator>Parmiter, Annette H.</creator><creator>Nowell, Peter C.</creator><creator>Koprowski, Hilary</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19880101</creationdate><title>Structural Alteration in the MYB Protooncogene and Deletion within the Gene Encoding α -Type Protein Kinase C in Human Melanoma Cell Lines</title><author>Linnenbach, Alban J. ; Huebner, Kay ; Reddy, E. Premkumar ; Herlyn, Meenhard ; Parmiter, Annette H. ; Nowell, Peter C. ; Koprowski, Hilary</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c518t-ebb7fcbef6c3fb868846eb351afa0fd77c3a5ad03158f43899f76182b26f8c9d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Alleles</topic><topic>Biological and medical sciences</topic><topic>Cell growth</topic><topic>Cell Line</topic><topic>Cell lines</topic><topic>Chromosome Aberrations</topic><topic>Chromosome Deletion</topic><topic>Chromosomes</topic><topic>Chromosomes, Human, Pair 6</topic><topic>Complementary DNA</topic><topic>DNA Restriction Enzymes</topic><topic>DNA, Neoplasm - genetics</topic><topic>Enzymes</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes</topic><topic>Genes. Genome</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>Melanoma</topic><topic>Melanoma - enzymology</topic><topic>Melanoma - genetics</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Nucleic Acid Hybridization</topic><topic>Oncogenes</topic><topic>Protein Kinase C - genetics</topic><topic>Proto-Oncogenes</topic><topic>Tumor cell line</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Linnenbach, Alban J.</creatorcontrib><creatorcontrib>Huebner, Kay</creatorcontrib><creatorcontrib>Reddy, E. Premkumar</creatorcontrib><creatorcontrib>Herlyn, Meenhard</creatorcontrib><creatorcontrib>Parmiter, Annette H.</creatorcontrib><creatorcontrib>Nowell, Peter C.</creatorcontrib><creatorcontrib>Koprowski, Hilary</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Linnenbach, Alban J.</au><au>Huebner, Kay</au><au>Reddy, E. 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Thirty cell lines derived from primary or metastatic melanomas of 28 patients were analyzed by Southern blotting with nicktranslated probes for 28 different genes, some of which map near frequent chromosomal breakpoints observed in melanoma. An alteration in the MYB protooncogene was observed in a cell line derived from a primary melanoma in the vertical growth phase, which correlated with a 6q22 chromosomal abnormality. Another primary melanoma cell line had a cytogenetically undetected tumor-specific deletion within the gene for α -type protein kinase C. Polymorphic alleles for the genes encoding the epidermal growth factor receptor and α -type protein kinase C were also observed.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>2829178</pmid><doi>10.1073/pnas.85.1.74</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Alleles Biological and medical sciences Cell growth Cell Line Cell lines Chromosome Aberrations Chromosome Deletion Chromosomes Chromosomes, Human, Pair 6 Complementary DNA DNA Restriction Enzymes DNA, Neoplasm - genetics Enzymes Fundamental and applied biological sciences. Psychology Genes Genes. Genome Haplotypes Humans Melanoma Melanoma - enzymology Melanoma - genetics Molecular and cellular biology Molecular genetics Nucleic Acid Hybridization Oncogenes Protein Kinase C - genetics Proto-Oncogenes Tumor cell line |
| title | Structural Alteration in the MYB Protooncogene and Deletion within the Gene Encoding α -Type Protein Kinase C in Human Melanoma Cell Lines |
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